Α-Toluenesulphonyl Fluoride

Duxiu Chemical

Specifications

HS Code	229661
Chemical Formula	C7H7FO2S
Molar Mass	174.19 g/mol
Appearance	White solid
Odor	Odorless
Density	1.32 g/cm³
Melting Point	65 - 67 °C
Boiling Point	145 - 148 °C at 1.5 mmHg
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in dichloromethane, chloroform, ethyl acetate, etc.
Purity Typical	≥98%
Storage Condition	Stored at -20 °C, protected from moisture

As an accredited Α-Toluenesulphonyl Fluoride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100 g of α -Toluenesulphonyl Fluoride in a sealed, chemical - resistant container.
Storage	α -Toluenesulphonyl Fluoride should be stored in a cool, dry place, away from heat sources and direct sunlight. It should be kept in a well - sealed container to prevent exposure to moisture and air, which could lead to decomposition. Store it in a dedicated chemical storage area, segregated from incompatible substances like strong acids, bases, and reactive compounds.
Shipping	α -Toluenesulphonyl Fluoride is shipped in accordance with strict chemical regulations. It's typically in sealed, corrosion - resistant containers, carefully packaged to prevent leakage during transit, ensuring safety at all times.

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General Information

Historical Development

Taste the chemical industry, the category is rich, the material is varied. Toluenesulphonyl Fluoride, in the field of chemical industry, also occupies a place. It first appeared, although it is not detailed in what year, but the chemical industry sages have dedicated themselves to study, so that its performance and function are gradually known.
At first, it was only explored by a few scholars, and its characteristics were carefully studied in laboratories. Later, with the advance of chemical technology, people found that it has a unique effect in many reactions. It can be catalyzed, or it can be modified, and its use is gradually widening. Since its inception, countless craftsmen have dedicated their efforts to exploring its extremes, causing this product to become more and more important in the chemical industry, from little known to widely used. This is also the course of its development.

Product Overview

Toluenesulphonyl Fluoride is also a chemical substance. Its special characteristics are valuable in the study of chemistry. This product or liquid is clear in color and has a special taste.
It has a great effect on chemistry and reaction, and is often used as a chemical reaction. It can interact with multiple compounds, so as to make a specific chemical.
This product needs to be controlled according to the precise process, and each step needs to be controlled, such as degree, force and reaction, etc.
It should be used with caution, because it may have a certain degree of danger. It is safe to comply with regulations, so as to ensure the safety of researchers and the interests of researchers. In addition, Toluenesulphonyl Fluoride is an indispensable material in the field of chemical research.

Physical & Chemical Properties

Today there is a substance called Toluenesulphonyl Fluoride. Its physical and chemical properties are particularly important. This substance may assume a specific state at room temperature, its color may be viewed, or it may have a unique luster, and it also has its special taste when smelled. Its melting and boiling point is fixed, which is related to its morphological transformation at different temperatures.
In terms of its chemical properties, it can react with many substances. When encountering a certain type of reagent, it can be replaced or added. Due to its special structure, it exhibits unique properties in chemical reactions and may be of extraordinary use in organic synthesis and other fields. Studying its physical and chemical properties can lay the foundation for many applications, and also help our generation to understand the essence of this substance, which will add to the way of scientific exploration.

Technical Specifications & Labeling

Today there is Toluenesulphonyl Fluoride, and its process specifications and identification (product parameters) are the key. In the process specifications, it is necessary to specify the preparation method, the geometry of the materials used, and the reaction conditions, such as temperature, duration, pressure, etc. And the operation process also needs to be orderly and not disordered.
As for the identification (product parameters), when marking its purity geometry, some impurities, and physical properties, such as color, taste, state, etc. And its chemical properties cannot be omitted, and its stability and reactivity need to be clear. In this way, the product can be used without error, achieve its function, and be used by users, which is beneficial to all things in the chemical industry.

Preparation Method

Toluenesulphonyl Fluoride is the first to prepare its raw materials. It is necessary to obtain toluene, and by sulfonation, it can be reacted with fuming sulfuric acid. In this step, p-toluenesulfonic acid can be obtained. Fuming sulfuric acid is strong and strong, so be careful not to hurt the body.
The second time is to react with p-toluenesulfonic acid and fluorinating agent. The choice of fluorinating agent is related to the purity of the product. When reacting, control its temperature and rate, step by step, and do not cause a burst.
And set up a catalytic mechanism, so that the reaction speed and efficiency are high. Select a good catalyst to reduce the reaction time and increase the amount of product.
The whole process of preparation needs to be carefully observed, each step is orderly, and the process can be followed to obtain a good product to meet all requirements.

Chemical Reactions & Modifications

At a certain moment in the evening, in the room of the order, there is a chemist who specializes in the study of a product called Toluenesulphonyl Fluoride. The study of this chemical product focuses on transformation and modification.
At the beginning, only a little is known about the reaction rules of this product. The reaction conditions are harsh, and it is difficult to get good results. And its properties are not good, and its application is quite constrained.
However, this person is not discouraged, and he is dedicated to trying his best to study the mechanism. After months of trial, he changes the temperature and the amount of reagents, and observes the corresponding changes.
Finally, something is gained, and the method of reaction is improved. The reaction conditions are gradually widened, and the efficiency is also increased. The properties of this material, modified and excellent, the field of application, thus wide. This chemist, with perseverance, broke the problem, so that the transformation and modification of Toluenesulphonyl Fluoride to a new level, praised by the academic community.

Synonyms & Product Names

Toluenesulphonyl Fluoride, Chinese name toluenesulphonyl fluoride, is very important in the fields of chemical industry and medicine. There are many other names, such as toluenesulphonyl fluoride. In many trade names, it can also be found.
Although ancient chemistry was not as precise as it is today, the heart of exploration and knowledge has not changed. Today's Toluenesulphonyl Fluoride may have had different names in the past, but its essential characteristics have gradually become clear to the world.
In the process of research and development, many assimilated names and trade names have emerged, all of which are more accurate descriptions of its properties and uses. Many researchers have worked hard to reveal its mysteries. This Toluenesulphonyl Fluoride, its assimilated name and trade name, witnessed the path of chemical exploration and paved the way for future research.

Safety & Operational Standards

Toluenesulphonyl Fluoride is also a chemical substance, which is commonly used in the room. However, the safe operation of this substance should not be careless.
Its sexual poison, which can be harmful to the human body, smelled or eaten. Therefore, when handling this substance, it is necessary to take protective equipment, such as gloves and masks, and use it for good, to prevent its poison from gathering.
The use of this substance, it is advisable to take it according to the amount of fine, and do not use it. If you note it, you should be careful to prevent it from coming out. If you are not careful about your body, you should quickly use a lot of water to remove it, that is, ask for it.
If you keep this object, there is also a problem. It is advisable to place it in a place where things are dry and transparent. It is a source of fire and a source of fire, and it should not be mixed with other things, for fear of life-threatening transformation.
Use it, and do not use it. It must be handled according to specific laws to ensure the safety of the environment. In this way, only when using Toluenesulphonyl Fluoride can it be safe and operate properly, and avoid the same hazards.

Application Area

Today there is Toluenesulphonyl Fluoride, which has a wide range of application fields and is quite important. In the field of biochemical research, it is often used as a protease inhibitor. Those that cover proteases can hydrolyze proteins, while Toluenesulphonyl Fluoride can combine with protease activity check points to inactivate it, thereby hindering protein hydrolysis.
The road of medical pharmaceuticals also has its own shadow. It can inhibit the activity of specific enzymes, or can be used to develop drugs for the treatment of enzyme-related diseases. And in the field of organic synthesis, Toluenesulphonyl Fluoride can be used as a fluorination reagent, participate in many organic reactions, and help synthesize organic compounds with special structures. It also has potential value in the research and development of new materials. It is an important chemical that is widely used.

Research & Development

Today there is Toluenesulphonyl Fluoride, which is increasingly important in our field of chemical research. Our researchers have carefully studied its characteristics, properties and applications. After long-term investigation, it has gradually become clear that it can be a key medium in many reaction mechanisms, and has a significant impact on the process and products of the reaction.
Looking at its development, in the past, due to the complicated preparation process and high cost, its promotion and application were limited. However, today is different from the past. The progress of scientific research has enabled the preparation method to be optimized and the cost to be controlled. This is an opportunity to promote its wide application. In the future, we look forward to leveraging the unique properties of Toluenesulphonyl Fluoride in the fields of medicine, materials, etc., to explore new frontiers, create more possibilities, and contribute to the development of the chemical field.

Toxicity Research

Those who have studied poisons recently have the name Toluenesulphonyl Fluoride. We study its toxicity carefully, observe its properties in detail, and investigate its use in detail.
Although this agent has some applications in industry and scientific research, its toxicity cannot be underestimated. After various experiments, observe its impact on the organism, observe its reaction to enter the body, damage the viscera, mess with qi and blood, and poison is even more harmful.
Those who use this substance should be cautious. In the laboratory, strict regulations must be followed, and comprehensive precautions must be taken to prevent leakage and harm the body. The research of poisons is related to life and must not be ignored. Although seeking scientific progress, life is paramount, and toxic substances are always studied, safety is always the priority, and we must not be careless, causing harm to living beings.

Future Prospects

Today, there is Toluenesulphonyl Fluoride, which has emerged in the field of chemical research. Its unique nature and wide range of uses can often produce amazing results in various reactions.
Looking at the current state, although it has been achieved, there are still infinite possibilities for future development. It can be explored for new uses in medicine, or as a cure for diseases; in the world of materials, or as a cornerstone of innovation.
Our generation should be enterprising, poor in its understanding, and expand its use. With time, Toluenesulphonyl Fluoride will be able to bloom more brilliantly, for the well-being of the world, and become a great cause in the future. Live up to the original intention of scientific research and go to the smooth road of light.

Where to Buy Α-Toluenesulphonyl Fluoride in China?

As a trusted Α-Toluenesulphonyl Fluoride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading Α-Toluenesulphonyl Fluoride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is α-Toluenesulphonyl Fluoride?

α-toluenesulfonyl fluoride is an important compound in organic chemistry. It has a unique chemical structure and is formed by linking toluenesulfonyl groups to fluorine atoms. This compound plays a key role in many organic synthesis reactions.
In chemical reactions, α-toluenesulfonyl fluoride is often used as a sulfonylating agent. Because of its high reactivity, sulfonyl groups can react with many nucleophiles, such as alcohols and amines. When reacted with alcohols, sulfonate esters can be formed. This reaction is often used in organic synthesis to introduce sulfonate groups to change the physical and chemical properties of compounds.
α-toluenesulfonyl fluoride reacts with amines to form sulfonamides. Sulfonamide compounds are of great significance in the field of medicinal chemistry. Many drug molecular structures contain this group, which has a great impact on the activity and solubility of drugs.
In addition, α-toluenesulfonyl fluoride is also a commonly used tool in the design of organic synthesis strategies because of its reactivity and selectivity. Chemists can use this compound skillfully to construct complex organic molecular structures and promote the development of organic synthesis chemistry. And under some special reaction conditions, it can exhibit unique reaction paths and products, opening up new directions for the study of organic chemistry.

What are the main uses of α-Toluenesulphonyl Fluoride?

α-toluenesulfonyl fluoride, an important reagent in organic chemistry, has a wide range of uses.
In the field of biochemical research, it is a protease inhibitor and plays a significant role. Many proteases perform proteolysis in living organisms. If left unregulated, it may cause physiological dysfunction. α-toluenesulfonyl fluoride can covalently bind to the serine residue at the protease activity check point, which can change the structure of the protease activity center and then inhibit protease activity. For example, trypsin, which plays a key role in protein digestion and various physiological processes, α-toluenesulfonyl fluoride can precisely inhibit trypsin, helping researchers to explore trypsin function and related physiological and pathological mechanisms.
In the field of organic synthesis, α-toluenesulfonyl fluoride is also a commonly used reagent. It can participate in nucleophilic substitution reactions. Due to the strong electron-withdrawing properties of fluorine atoms, sulfonyl groups are more susceptible to attack by nucleophilic reagents. For example, when reacted with alcohols, toluenesulfonate can be formed. This product is a good leaving group. It can be used as a key intermediate in subsequent organic synthesis steps, such as the formation of carbon-carbon bonds and carbon-heteroatomic bond reactions, to assist in the synthesis of complex organic molecules.
In the pharmaceutical industry, α-toluenesulfonyl fluoride can be used in drug development and production. In the lead compound optimization stage, with the help of its interaction characteristics with specific enzymes, compounds with specific biological activities are designed and synthesized, laying the foundation for the creation of new drugs. And in some drug production processes, it participates in specific reaction steps as a reaction reagent to ensure the smooth progress of drug synthesis.
In addition, α-toluenesulfonyl fluoride can also be used for material surface modification. After appropriate treatment, it can react with material surface groups to change the surface chemical properties of materials, such as improving material surface hydrophilicity, stain resistance, etc., expanding the application range of materials, with potential applications in coatings, textiles, biomaterials and other fields.

What are the precautions for the use of α-Toluenesulphonyl Fluoride?

Alpha-Toluenesulphonyl Fluoride (α-Toluenesulphonyl Fluoride) is a commonly used reagent in organic synthesis, and many precautions should be kept in mind when using it.
First safety protection. This reagent is toxic and irritating, or can cause damage to the skin, eyes and respiratory tract. Be sure to wear appropriate protective equipment when using it, such as protective gloves, goggles and laboratory work clothes. The operation should be carried out in a well-ventilated fume hood to prevent inhalation of its volatile gases.
Second discussion on storage conditions. It should be stored in a cool, dry and ventilated place, away from fire sources and oxidants. Due to its active chemical properties, improper storage or danger. It should be stored strictly in accordance with the specified conditions to prevent deterioration or cause safety accidents.
Furthermore, the use process needs to be precise and careful. Due to its high reactivity, the weighing and transfer operations should be rapid and accurate to avoid long-term exposure to air. The utensils used must be clean and dry to avoid impurities affecting their performance and reaction results.
Also pay attention to its compatibility with other substances. Before entering the reaction, it is necessary to clarify whether it will have adverse reactions with other reagents in the reaction system. In some cases, it may be necessary to conduct a small test in advance to evaluate its feasibility and safety.
Treatment after use should not be ignored. Waste containing α-toluenesulfonyl fluoride should be properly disposed of in accordance with relevant regulations and should not be discarded at will to avoid polluting the environment. The reaction products and remaining reagents should also be disposed of reasonably to ensure compliance with environmental protection and safety requirements.

What are the storage conditions for α-Toluenesulphonyl Fluoride?

Alpha-toluenesulfonyl fluoride is a commonly used reagent in organic synthesis. Its storage conditions are very critical, related to its stability and effectiveness.
Cover alpha-toluenesulfonyl fluoride has certain chemical activity and is easy to react with many substances. Therefore, when storing, the first priority is to be in a low temperature environment. It should be stored in a freezing environment of about -20 ° C. This low temperature can slow down its chemical change rate and keep it in a relatively stable state. Due to the increase in temperature, the molecular activity is enhanced, which is easy to trigger reactions such as decomposition and polymerization, which will damage its chemical properties.
Furthermore, attention should be paid to isolating air and moisture. Alpha-toluenesulfonyl fluoride is prone to hydrolysis in contact with water or water vapor in the air, resulting in deterioration. Therefore, the storage container must be well sealed, commonly used airtight glass or plastic bottles, and an appropriate amount of desiccant can be placed in the bottle, such as anhydrous calcium chloride, silica gel, etc., to absorb water vapor that may penetrate.
In addition, light should be avoided. Light can provide energy to promote photochemical reactions of alpha-toluenesulfonyl fluoride, which affects its quality. Therefore, the storage place should be a dark place, or the storage container should be wrapped in opaque materials.
Overall, to properly store α-toluenesulfonyl fluoride, low temperature, sealing, and protection from light are essential to ensure that it maintains good chemical properties during storage for subsequent experiments or production.

What are the market prospects for α-Toluenesulphonyl Fluoride in related fields?

Alpha-toluenesulfonyl fluoride is widely used in various fields of chemical industry. In the field of pharmaceutical and chemical industry, it is an important synthetic raw material. When it comes to pharmaceuticals, it can be used to prepare a variety of special drugs, such as some antibacterial and antiviral drugs, and its effectiveness in disease prevention and control cannot be underestimated. In today's pharmaceutical market, demand is growing. Due to the wide variety of diseases, new diseases have also emerged from time to time. Pharmaceutical developers are seeking better synthesis paths and raw materials. Alpha-toluenesulfonyl fluoride has won many favor because of its characteristics, and is often a key choice in the creation of new drugs.
In the field of organic synthesis, it also has an extraordinary position. Organic synthesis involves the preparation of many fine chemicals, such as high-end coatings and special plastics. α-toluenesulfonyl fluoride can be used as a reagent for special reactions, assisting chemists in constructing unique molecular structures to meet the needs of various industries for special performance materials. At present, with the rapid development of science and technology, the rise of high-end manufacturing, and the growing demand for special performance materials, the demand for α-toluenesulfonyl fluoride in this field will also rise.
However, this product is circulated in the market and is also subject to strict regulations. Because of its certain toxicity and danger, production, transportation and storage must follow specific specifications. Therefore, despite the promising market prospects, practitioners must adhere to safety and regulatory principles to ensure that their applications are both effective and safe.