Pyridine-2-Sulfonyl Fluoride

Duxiu Chemical

Specifications

HS Code	706113
Chemical Formula	C5H4FNO2S
Molecular Weight	161.15
Appearance	Solid (usually white to off - white)
Melting Point	Typically in a certain range, e.g., around 60 - 65 °C
Solubility	Soluble in some organic solvents like dichloromethane, dimethylformamide
Pka	Relevant to its acidic or basic properties in solution
Density	Specific value depending on conditions, e.g., around 1.4 g/cm³
Stability	Stable under normal conditions, but may react with strong bases or oxidizing agents
Ir Absorption Bands	Characteristic bands for functional groups like C - F, S = O, etc.

As an accredited Pyridine-2-Sulfonyl Fluoride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of Pyridine - 2 - Sulfonyl Fluoride packaged in a sealed chemical - grade bottle.
Storage	Pyridine - 2 - Sulfonyl Fluoride should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly closed container to prevent exposure to moisture and air, which could lead to decomposition. Store it separately from incompatible substances, like strong oxidizing agents and bases, to avoid potential reactions.
Shipping	Pyridine - 2 - Sulfonyl Fluoride, a chemical, is shipped in well - sealed, corrosion - resistant containers. Special care is taken to comply with hazardous material regulations during transportation to ensure safety.

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General Information

Historical Development

Pyridine-2 Sulfonyl Fluoride (Pyridine 2 Sulfonyl Fluoride) is also a special product among chemical substances. Tracing its origin, the academic community has gradually deepened its exploration of sulfonyl fluoride at the beginning, and its attention has also focused on the unique structure of Pyridine-2-sulfonyl fluoride.
At first, the synthesis method was still simple, but the purity and yield were not sufficient. After several years, the sages worked hard to improve the process, so that the yield rose and the purity was also high. The application path was initially narrowed to niche experiments. However, with the progress of research, it has emerged in the fields of medicinal chemistry and organic synthesis, and can be a key intermediate, assisting in the creation of new drugs, and organic reactions also depend on it. With the passage of time, this product has become increasingly important and has gradually occupied a place in the forest of chemistry. It is valued by future researchers and has a good prospect. It is expected to explore new frontiers and start a new chapter in chemical applications.

Product Overview

Pyridine 2 Sulfonyl Fluoride is also a chemical compound. Its properties are special and exquisite. It contains pyridine and sulfonyl fluoride. The combination of the two affects the properties of ordinary substances.
The use of this substance is very important, and it is often powerful in the field of chemical synthesis. It can be used for many reactions, leading to the opposite direction, and forming a specific compound. Among its anti-activity, it can control the process of reaction, and obtain a high-quality compound.
It is also used in biochemical research, which also affects it. Or it can act on specific proteins, helping researchers to understand the secrets of biochemistry. In addition, Pyridine 2 Sulfonyl Fluoride has significant chemical and biochemical properties due to its unique properties.

Physical & Chemical Properties

Pyridine-2-sulfonyl fluoride is also a chemical substance. It has unique physical and chemical properties. Looking at its physical properties, under room temperature, or as a solid state, it is white and pure, with a specific melting point and boiling point, which can be used in different temperature environments to know the change of its physical state. As for chemistry, its sulfonyl fluoride group is active and easily reacts with many substances. In case of nucleophiles, fluorine atoms are easily replaced to form novel compounds. Because of its activity, it is widely used in the field of organic synthesis, or it is a key intermediate, assisting in the formation of complex organic molecules. The understanding of the physical and chemical properties of this substance is the cornerstone of chemical research and application, and is of important value in materials, medicine and other industries.

Technical Specifications & Labeling

The technical specifications and identification (product parameters) of this product are the key. The technical specifications are related to the purity and heterogeneity of the material, and the preparation method must be carefully reviewed. From the beginning of material selection, the quality must be pure and flawless, and all raw materials should be matched according to the ratio, so as not to make any difference. When preparing, the heat and duration are all important, and the control is moderate to get a good product.
As for the identification (product parameters), it should be detailed and not hidden. If the purity is an item, it must be indicated by an accurate number, so that the quality can be clearly understood. The description of the characteristics should not be sparse, and the color and state should be confirmed. And the packaging label shall correct its name and be accompanied by necessary warnings, so that users can know its nature and its risks. In this way, the right path of technical specifications and identification (product parameters) can be combined, so that this product is beneficial to users and credible to the industry.

Preparation Method

The raw materials and production process, reaction steps and catalytic mechanism of this product of Pyridine 2 Sulfonyl Fluoride are the key. First take pyridine as the group, supplemented by the method of sulfonation, so that the sulfonic acid group can enter the two position, which is a priority. The sulfonated raw materials are selected as pure ones, such as high-quality pyridine and suitable sulfonating reagents. The ratio, reaction temperature and duration of the two need to be precisely controlled.
Then, the sulfonate and the fluorinating agent are met, and the fluorination reaction is carried out. The nature and dosage of the fluorinating agent, as well as the acid and base of the reaction environment and temperature are all related to success or failure. During the reaction steps, the stirring rate and the order of feeding should not be ignored, and the best effect can be obtained in sequence.
As for the catalytic mechanism, or use a specific catalyst to lower the reaction energy barrier and promote its speed. The choice of catalyst, the reaction characteristics must be combined, and the reaction is efficient and highly selective. In this way, Pyridine 2 Sulfonyl Fluoride is a good product.

Chemical Reactions & Modifications

Nowadays, there is a substance called Pyridine 2 Sulfonyl Fluoride. In the field of chemistry, its chemical reaction and modification are quite critical. The reaction of this substance, or in contact with nucleophiles, the fluorine atom is easily replaced, just like the ancient change of owners. The modification can be changed by introducing a specific group to change its physicochemical properties, just like dressing it with new clothes.
When it encounters a base, fluorine ions leave, and the molecular structure is remodeled, such as phoenix nirvana, a new state. After modification, its stability or solubility are increased, and its use is also expanded. In the process of organic synthesis, it can be used as a key intermediate to promote the formation of various compounds, serving as a bridge to connect different molecules, providing a boost to chemical research and industrial production.

Synonyms & Product Names

Today there is a thing named Pyridine 2 Sulfonyl Fluoride. It is a special product in the field of chemistry. This thing is also known as Yidong, which is its synonymous name. Its synonymous name is related to the trade name and is an indispensable part of chemical research.
In ancient chemical research, every new thing is discovered, which is obtained by scholars. The same is true for Pyridine 2 Sulfonyl Fluoride. All synonymous names are to represent its characteristics. The determination of the trade name is related to the use and characteristics of this thing, and other things.
In today's chemical research, the synonym and trade name of Pyridine 2 Sulfonyl Fluoride are used by students to make it clear and common, adding to the progress of chemistry. Scholars can follow this path to explore more mysteries and promote the rise of chemistry.

Safety & Operational Standards

"Code of Safety and Operation of Pyridine-2-Sulfonyl Fluoride"
Fukopyridine-2-sulfonyl fluoride is a commonly used product in chemical research. If you want to make good use of this product, you must first clarify its safety and operation specifications.
This product has a certain chemical activity and is strong in nature. When stored, it should be placed in a cool, dry and well-ventilated place, away from fire and heat sources, to prevent it from being exposed to heat and causing danger. And it should not be co-stored with strong oxidants, strong bases, etc., to avoid chemical reactions and cause disasters.
When operating, be sure to follow the rules strictly. The operator must wear protective clothing, goggles, and gloves to prevent it from splashing on the body, hurting the skin, and eyes. If used in the laboratory, the ventilation equipment should be fully turned on to allow harmful gases to escape in time and keep the indoor air fresh.
After use, the residue should not be disposed of at will. It needs to be properly disposed of according to specific methods to prevent it from polluting the environment. If you accidentally touch it, if your skin is stained, rinse it with plenty of water as soon as possible; if it enters your eyes, you must rinse it with water urgently and seek medical attention as soon as possible.
In short, although pyridine-2-sulfonyl fluoride has greatly contributed to chemical research, its safety and operating standards should not be ignored. Only by following this regulation can we ensure the smooth research, the safety of personnel, and the integrity of the environment.

Application Area

Pyridine-2-sulfonyl fluoride is useful in many fields. In the field of medicine, it can be used as a key raw material for creating good medicines and helping to heal various diseases. Because it can precisely act on specific targets, or can adjust the biochemical reactions of the human body, it can contribute to the elimination of diseases and diseases. In scientific research, it is also an indispensable reagent, which can assist in the analysis of the structure and function of biomolecules and help researchers clarify the mysteries of the microscopic world. In chemical production, it can improve the properties of materials, such as enhancing the stability and durability of materials. This is the application field of pyridine-2-sulfonyl fluoride, and its value in various fields is waiting for our generation to explore in depth, so as to make the best use of it and benefit the world.

Research & Development

I dedicated myself to the study of Pyridine 2 Sulfonyl Fluoride. At first, I explored its structure, analyzed its molecular composition in detail, and revealed the wonder of its atomic arrangement. Then I studied its properties, observed its reaction under various conditions, and learned the law of its chemical activity.
In terms of application, there are also many explorations. Observing its role in organic synthesis can add power to the reaction, making the path simpler and the product purer. And in the field of medicine, it seems to have potential value, or it can help the research and development of new drugs, and find new ways for the treatment of diseases.
However, the road to research is not smooth sailing. When analyzing its reaction mechanism, it often encounters difficulties, and many phenomena are difficult to solve. However, we adhere to the spirit of research and are unwilling to give up exploration, hoping to break through the predicament, so that the research and development of this substance can be taken to a higher level, adding new colors to the field of chemistry, and benefiting everyone.

Toxicity Research

Tasting the nature of poisons is important to people's livelihood. When it comes to Pyridine 2 Sulfonyl Fluoride today, the study of its toxicity is crucial.
The nature of this thing may be invisible, but it is harmful quietly. To study it in detail, we should carefully observe the changes in its contact with things, and observe the signs of its entry into the body. The study of poison in ancient times was often used to test things and observe the differences in their form and spirit. The same is true of Pyridine 2 Sulfonyl Fluoride today.
When it is in the environment, or mixed with water and soil, or dissolved with air, its diffusion path and retention are all important for the study of toxicity. It is also tested into the body of living things. The viscera and the blood that are messed up need to be studied carefully. Cover the harm of toxicity, not only hurt people's bodies, but also disrupt the order of nature. Therefore, the toxicity of Pyridine 2 Sulfonyl Fluoride cannot be ignored. In order to ensure the safety of people's livelihood and the balance of ecology, we should devote our efforts to this, understand its poison, and prevent problems before they occur.

Future Prospects

The prospect of the future, Pyridine 2 Sulfonyl Fluoride This thing has a bright future. In the field of chemical research, it is like a shining star. Today, all those who work today have their own limitations. In the future, or in the field of research and development, it can be used to expand the color, help those who control diseases, and save the world. Or in the world of material science, it can develop its unique properties and make materials more outstanding. The way of science has been cultivated for a long time, but with our scientific research heart and ambition to explore, Pyridine 2 Sulfonyl Fluoride will definitely be able to make its extraordinary power in the future.

Where to Buy Pyridine-2-Sulfonyl Fluoride in China?

As a trusted Pyridine-2-Sulfonyl Fluoride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading Pyridine-2-Sulfonyl Fluoride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the chemical structure of Pyridine-2-Sulfonyl Fluoride?

Pyridine-2-sulfonyl fluoride has a unique chemical structure. In terms of its name, the pyridine ring is a group, and this ring is a six-membered nitrogen-containing heterocycle, which is aromatic. At the second position of the ring, a sulfonyl fluoride group is connected. Sulfonyl fluoride is formed by connecting two oxygen atoms and a fluoride atom with a sulfur atom, and the sulfur atom is complex with the dicarbon of the pyridine ring.
In this structure, the nitrogen atom of the pyridine ring has a lone pair of electrons and is basic. It can form salts with acids and can also be used as ligands in reactions to complex with metal ions. In the sulfonyl fluoride group, the fluorine atom has strong electronegativity, which makes the sulfur atom partially positively charged, making the group highly reactive. After the fluorine atom leaves, the sulfonyl group can be substituted with the nucleophilic reagent to form new carbon-sulfur bonds or other chemical bonds.
Pyridine ring and sulfonyl fluoride group interact with each other. The electron cloud distribution of the pyridine ring is changed due to the electron-absorbing effect of sulfonyl fluoride, resulting in a decrease in the electron cloud density on the ring, and the electrophilic substitution reaction activity is different from that of unsubstituted pyridine. This unique chemical structure endows pyridine-2-sulfonyl fluoride with important application potential in organic synthesis, medicinal chemistry and other fields, and can be used as a key intermediate for constructing complex organic molecular structures.

What are the main uses of Pyridine-2-Sulfonyl Fluoride?

Pyridine-2-sulfonyl fluoride has a wide range of uses and is used in many fields.
First, it is often a key reagent in the field of organic synthesis. It can react with a variety of nucleophiles to help form new carbon-sulfur bonds, carbon-nitrogen bonds, etc., and then build complex organic molecular structures. For example, it reacts with compounds containing nucleophilic groups such as nitrogen, oxygen, and sulfur to achieve the introduction and transformation of specific functional groups, laying the foundation for the synthesis of new drugs, natural products, and functional materials.
Second, it is of great significance in the field of pharmaceutical chemistry. Due to its unique chemical properties, it can selectively react with biological macromolecules such as specific check points of proteins, or be used to modify proteins to explore the function and mechanism of action of proteins; or as a structural modification unit of lead compounds, optimize the activity, selectivity and pharmacokinetic properties of drug molecules, and help the research and development of new drugs.
Third, in the field of materials science, it also plays a role. It can participate in the modification process of material surfaces, giving materials special properties such as anti-corrosion and anti-biological pollution. By reacting with active groups on the surface of materials, it can change the chemical composition and properties of the material surface, and broaden the application scenarios of materials, such as biomedical materials, electronic materials and other fields.
In summary, pyridine-2-sulfonyl fluoride plays an important role in organic synthesis, medicinal chemistry, materials science and other fields due to its unique chemical properties, promoting the development and progress of various fields.

What are the physical properties of Pyridine-2-Sulfonyl Fluoride?

Pyridine-2-Sulfonyl Fluoride (Pyridine-2-Sulfonyl Fluoride) is a kind of organic compound. It has unique physical properties, which I will describe in detail.
This substance is either liquid or solid at room temperature and pressure, depending on its purity and specific environmental conditions. If it is liquid, its appearance may be colorless to light yellow transparent, uniform in texture, free to flow, and clear as a spring. Its odor may have a special irritation, and the smell is sensitive to the senses. This odor characteristic may be used as the basis for preliminary identification.
On the boiling point, the boiling point of pyridine-2-sulfonyl fluoride is affected by factors such as intermolecular forces. The pyridine ring in the molecule interacts with the sulfonyl fluoride group, causing the intermolecular forces to exhibit a specific intensity. Generally speaking, its boiling point may be within a certain range, which makes the substance change from liquid to gaseous state at a specific temperature.
Melting point is also an important physical property. The degree of orderly arrangement of the molecular structure of pyridine-2-sulfonyl fluoride determines its melting point. If the structure is regular and the intermolecular interaction is stable, the melting point is relatively high; conversely, if the molecular structure is slightly loose and the interaction is weak, the melting point is low.
In terms of solubility, it shows different performance in organic solvents. In polar organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), it may have good solubility. Due to the fact that the molecule of pyridine-2-sulfonyl fluoride has a certain polarity, it can attract and dissolve with polar organic solvents through intermolecular forces, just like water and water. In non-polar organic solvents, such as n-hexane, its solubility or poor, due to the large difference in the intermolecular forces between the two, it is difficult to mix with each other.
Density is also one of its physical properties. The density of pyridine-2-sulfonyl fluoride depends on its molecular weight and molecular accumulation mode. If the molecular mass is large and packed tightly, the density is relatively large; conversely, the density is small. This density property may be of great significance in practical applications such as separation and mixing.

What are the synthesis methods of Pyridine-2-Sulfonyl Fluoride?

The method of making pyridine-2-sulfonyl fluoride has been known for a long time. One method is to use pyridine-2-sulfonic acid as the starting material and make it co-heat with dichlorosulfoxide. In this reaction, dichlorosulfoxide is the conversion agent of sulfonyl chloride, and when the sulfonic acid group encounters it, it is easy to form sulfonyl chloride. After the sulfonyl chloride is obtained, it is mixed with anhydrous potassium fluoride, and the reaction is heated in a suitable organic solvent, such as acetonitrile. Because the activity of fluoride ions is stronger than that of chlorine, it can replace the chlorine in sulfonyl chloride to obtain pyridine-2-sulfonyl fluoride.
There is another method, using pyridine as the starting material, first heating with fuming sulfuric acid and sulfur trioxide to make it sulfonated to obtain pyridine-2-sulfonic acid. This step requires proper temperature control to ensure that the sulfonic acid group can be positioned at the 2-position of pyridine. Then, similar to the above, pyridine-2-sulfonic acid is converted to sulfonyl chloride, and then fluorinated to obtain the final target product.
Another way is to use 2-halogenated pyridine as the raw material and react with sodium thiosulfate, so that the halogen atom is replaced by thiosulfate, and then oxidized to sulfonic acid. Subsequent conversion and fluorination of sulfonyl chloride can also achieve the synthesis of pyridine-2-sulfonyl fluoride. All methods have their own advantages and disadvantages, depending on the availability of raw materials, the ease of control of reaction conditions and the high or low yield.

What are the precautions for using Pyridine-2-Sulfonyl Fluoride?

When using pyridine-2-sulfonyl fluoride, many things need to be paid attention to.
First, safety is of paramount importance. Pyridine-2-sulfonyl fluoride is toxic and irritating. When operating, be sure to wear suitable protective equipment, such as protective gloves, goggles and gas masks, to avoid direct contact with the skin and eyes, and to prevent inhalation of its volatile gas. In case of accidental contact, rinse with plenty of water immediately and seek medical treatment quickly according to the specific situation.
Second, proper storage is extremely important. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Due to its active chemical properties, it is easy to react with many substances, so it must be stored separately from oxidants, alkalis, etc., and should not be mixed to prevent dangerous chemical reactions.
Third, the use environment should not be ignored. The operation should be carried out in a fume hood to ensure smooth ventilation in the operating space, and the volatile gas can be discharged in time to reduce the concentration of the substance in the air to ensure the safety of operators.
Fourth, the exact dosage needs to be controlled. According to the specific needs of the experiment or production, the dosage of pyridine-2-sulfonyl fluoride should be accurately calculated and measured to avoid waste caused by excessive use and subsequent treatment problems. And during use, the action should be stable and accurate to prevent the substance from splashing out.
Fifth, waste disposal is appropriate. After use, the remaining pyridine-2-sulfonyl fluoride and related waste must not be discarded at will. It needs to be treated harmlessly in accordance with relevant regulations, or handed over to a professional recycling agency to prevent pollution to the environment.