Phenylsulfonylfluoride

Specifications

HS Code	693391
Name	Phenylsulfonylfluoride
Chemical Formula	C6H5SO2F
Molar Mass	160.165 g/mol
Appearance	Colorless to pale yellow liquid
Odor	Pungent odor
Density	1.326 g/cm³
Boiling Point	202 - 203 °C
Melting Point	−21 °C
Solubility	Slightly soluble in water, soluble in organic solvents
Flash Point	88 °C
Stability	Stable under normal conditions but reactive with strong bases and reducing agents
Main Use	Inhibitor of serine proteases

As an accredited Phenylsulfonylfluoride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	Phenylsulfonylfluoride in 100 - gram bottles, securely sealed for chemical storage.
Storage	Phenylsulfonyl fluoride should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly - sealed container to prevent contact with air and moisture, which could lead to decomposition. Store it separately from incompatible substances like oxidizing agents and bases to avoid potential reactions.
Shipping	Phenylsulfonylfluoride, a hazardous chemical, is shipped in specialized, leak - proof containers. It adheres to strict DOT regulations. Shipment requires proper labeling for its toxic and reactive nature, with careful handling to prevent spills.

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General Information

Historical Development

In the past, those who studied chemical things focused on Phenylsulfonylfluoride products. At the beginning, their understanding was still shallow, and only a little bit of their properties were known. However, after years of unremitting research, the solution of its structure and properties has gradually deepened. Beginning to know that it is in the field of biochemistry, it can make inhibitors, block the activity of enzymes, and has significant effects.
The road to exploration in the past has been difficult. Scholars study day and night, using various methods to measure its properties and analyze its structure. In the end, it has been successful, and its application has also become wider. Since its discovery, Phenylsulfonylfluoride has played an important role in all aspects of medical research. From ignorance and ignorance to wide application, this is the process of scientific research progress, and it has also witnessed the development of chemistry.

Product Overview

"Phenyl sulfonyl fluoride"
Phenyl sulfonyl fluoride is also a wonderful product in the process of transformation. Its shape is mostly a colorless liquid with a specific taste. It is more active in nature and shows its ability in many chemical reactions.
In the field of biochemistry, its power is very great. It is often an inhibitor of protease, which can stop the activity of enzymes and make the biochemical process follow the rules. With its close contact with the active site of the enzyme, it breaks the catalytic chain and protects the stability of the biochemical system.
In organic synthesis, it is also a good aid. It can participate in the reaction, help the formation of new bonds, and expand the way of synthesis. Although it is widely used, it should be used with caution. Because it has a certain poison, touch it, smell it or have trouble, so the operator must follow the rules, prepare protective gear, and protect the body, in order to make good use of this product and promote the prosperity of the chemical industry.

Physical & Chemical Properties

Phenyl sulfonyl fluoride is strong and active, with strong reaction ability. Its shape may be a colorless liquid, and the gas is pungent and strong. The melting and boiling point is fixed, and it can be stable at room temperature. However, when exposed to heat and alkali, it will change and change, and the transformation should be different.
This substance is very useful in the field of organic synthesis. It is often used as a reagent to promote the progress of reaction, form bonds and structures, and help many compounds to survive. In biochemical research, it also plays an important role, which can control the activity of enzymes and the nature of enzymes. Xie's path in the Ming Dynasty.
However, it is poisonous, touching it and smelling it are harmful to health. Be careful when using it, operate in accordance with regulations, protect it well, and avoid harm to yourself. Study its nature and study its use, in order to increase the benefits and reduce the harm, so as to help the science advance and benefit the world.

Technical Specifications & Labeling

Phenylsulfonylfluoride, it is also the thing that transforms. The quality of the technology of its creation is of paramount importance. Where this thing is made, the raw materials must be high, and the proportion is high. The quality of the reverse parts, such as the degree and quality, needs to be controlled. If the quality is high, the reaction will be strong, or the side effects will be produced; if the quality is low, the reaction will be slow, and the effect will be good.
The quality of its products should not be ignored. The composition and content of the product are clear, and there are warnings attached. If the content is insufficient, the effectiveness will be low; if the quality is unknown, or the user will use it, it will be like a health problem. The quality of the product is not good (the quality of the product is not good), it is necessary to use it Phenylsulfonylfluoride, and it should not be careless.

Preparation Method

Phenyl sulfonyl fluoride is made today, and the first raw material is selected. When benzenesulfonic acid and thionyl chloride are taken as the main materials, the purity of the two is better. The preparation process first makes benzenesulfonic acid and thionyl chloride co-placed in the kettle, the temperature is moderately controlled, and slowly heated. Looking at the reaction process, at the beginning, the liquid in the kettle gradually boils and bubbles escape. As the reaction advances, the smell gradually changes, and the color changes slightly.
The reaction step starts at a low temperature of about 30 degrees, so that the two are initially fused and touched, and then gradually heats up to 60 degrees, and the temperature is kept stable for about two hours. This process needs to be stirred often to promote its full reaction. Its catalytic mechanism, chlorine of thionyl chloride is active, and the hydroxyl group in benzenesulfonic acid leaves to form phenyl sulfonyl chloride, and then reacts with the fluorinating agent to obtain phenyl sulfonyl fluoride. In this way, the production method is stable and pure, and it can be a good method.

Chemical Reactions & Modifications

Taste the wonders of chemical industry, it is related to the change of all things. In today's discussion Phenylsulfonylfluoride this substance, its reaction and modification in chemistry is really meaningful.
Phenylsulfonylfluoride, often in the field of organic synthesis to show its properties. Its reactive activity is unique, and it can interact with many functional groups, or nucleophilic substitution, or addition polymerization, all of which are wonderful. In the reaction, the characteristics of its structure make the reaction path more controllable, so that a variety of products can be obtained.
And looking at its modification work, it can give materials new properties. Or increase its stability, or change its solubility, adding bricks to material science. However, if you want to make good use of it, you must carefully observe its reaction mechanism and understand the changes in conditions, so that you can control it freely, causing it to bloom in the path of chemistry and contributing to the progress of science.

Synonyms & Product Names

In the field of chemical industry, there is a thing called Phenylsulfonylfluoride. The alias and trade name of this thing are also our research. Its alias may be called benzenesulfonyl fluoride. As for the trade name, it also has its specific title in the city.
Phenylsulfonylfluoride, in the chemical industry, has a wide range of uses. Or as a raw material for synthesis, or in a certain type of reaction, plays an important role. Its quality of benzenesulfonyl fluoride shows its unique nature, which is the refinement of chemical technology and adds to the building block. We study the aliases and trade names of this product to fully understand its various characteristics in the industry, so that we can make good use of it to promote the chemical industry, move forward vigorously, and do our best in various applications.

Safety & Operational Standards

"Specifications for the Safety and Operation of Phenylmethylsulfonyl Fluoride Products"
Phenylmethylsulfonyl fluoride (Phenylsulfonylfluoride) is unique in the category of chemical agents, and its safety and operation standards cannot be ignored.
In terms of safety, this is the top priority. Phenylmethylsulfonyl fluoride is toxic and can be harmful if it touches the skin, inhaled or ingested by mistake. Therefore, when exposed, strict protection must be followed. Workers should wear protective clothing, gloves and masks to avoid harm. If they accidentally touch the skin, rinse with plenty of water and seek medical treatment; if inhaled, move to a well-ventilated place quickly, and apply first aid if necessary.
As for the operation specifications, also need to be cautious. In terms of storage, it should be placed in a cool, dry and well-ventilated place to avoid heat and fire sources. When taking it, measure it accurately and do not do it at will. In the experimental operation room, the instrument must be clean and dry to prevent impurities from reacting with it. The operation process needs to be carried out in a fume hood to ensure the circulation of air and prevent the accumulation of harmful gases.
Furthermore, waste disposal cannot be ignored. Waste of benzylsulfonyl fluoride should not be discarded at will. It should be properly disposed of in accordance with the regulations to prevent pollution of the environment and harm to all living beings.
In short, the safety and operating standards of phenylmethylsulfonyl fluoride products are related to personal safety and the well-being of the environment. We chemical researchers must follow them carefully and not slack off.

Application Area

Phenylsulfonylfluoride this substance is widely used in the field of biochemistry. It can be used in enzymatic research to produce serine protease. The activity check point of this enzyme contains serine residues, which Phenylsulfonylfluoride can covalently bind to it to inactivate the enzyme, so as to study the function and mechanism of the enzyme.
In neuroscience, it is also quite important. It can block acetylcholinesterase, which is hydrolyzed by acetylcholine. If it is inhibited, acetylcholine accumulates and aids in research nerve conduction.
In addition, protein purification can protect protein activity. Due to its ability to inhibit protease, prevent protein degradation, and maintain its integrity and activity, it is a powerful tool for biochemical research and is of great use in various fields.

Research & Development

In recent times, chemistry has been refined, and new things have emerged. Phenylsulfonylfluoride this thing, it has gradually become a trend of research in the academic world. Its unique nature and wide utility can be a sharp tool for biochemical research.
All researchers have worked hard to study its structure, explore its reaction, and want to understand its properties in various environments. At the beginning, the cognition is still shallow, and there are many mistakes. However, the researchers are not discouraged, and they move forward. After a long time of study, their synthesis methods have gradually improved. The difficulties at the beginning are now simple, and the yield has also increased.
The field of its application is also gradually expanding. In the field of medicine, it can help to explore the source of disease and develop new drugs; in biochemical experiments, it can make specific reagents and help analyze the microscopic mechanism. Therefore, the research of Phenylsulfonylfluoride is in the ascendant and has a bright future. It will be beneficial to the advancement of science and technology in the future.

Toxicity Research

Taste the industry of chemical industry, study poisons, hope to gain something, so as to benefit the people of the world. Today there are Phenylsulfonylfluoride of this substance, and the study of its toxicity is quite important.
Those who study it must be cautious. This substance enters the body, or it disrupts the order of physiology, harming the viscera. Looking at its properties, it can control the activity of enzymes, those who are enzymes, and the cardinal of life. Enzyme disorder is plagued with diseases.
However, the study of toxicity is not achieved overnight. It must be observed that its dosage and reaction change, or in the genus of white rats, test its toxicity. Observe the differences in its diet and activities, and analyze its physiological changes.
It is also necessary to explore its shadow in the environment, scattered outside, or sewage and soil, harming life. Therefore, the investigation of toxicity is related to people's livelihood and the environment, and it must be detailed. Only by understanding its harm can we make good use of it to avoid disaster.

Future Prospects

I have tried to study Phenylsulfonylfluoride this substance, and I know its properties. This substance has a wide range of uses in the field of biochemistry, can make inhibitors, block the activity of enzymes, and has high expectations in the process of medical exploration and scientific research.
The current state of the viewer, although many achievements have been made, the road ahead is still long. In the future, we should focus on the method of precise synthesis, and strive to increase the yield and reduce its cost. I also hope to expand its use, and it will emerge in the treatment of new diseases and the rise of new technologies.
I believe that with time, with the diligence of all researchers, Phenylsulfonylfluoride will be brilliant, and add bricks and tiles to human well-being. It will develop endless possibilities and become a treasure in the field of biochemistry.

Where to Buy Phenylsulfonylfluoride in China?

As a trusted Phenylsulfonylfluoride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading Phenylsulfonylfluoride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of Phenylsulfonylfluoride?

Phenylmethylsulfonyl fluoride (Phenylsulfonylfluoride), often referred to as "PMSF", is one of the most useful organic chemicals. Its main uses are roughly as follows:
First, it plays a significant role in the field of protease inhibition. Proteases play a key role in the process of proteolysis, and PMSF can tightly bind to the hydroxyl group of the protease activity check point serine residue to form a stable covalent bond, which in turn inhibits protease activity. This property is of great significance in biochemical research. For example, during cell lysis, intracellular proteases can degrade target proteins, making it difficult to obtain pure and complete target proteins for experiments. Adding PMSF can effectively inhibit the action of proteases, ensure the integrity of the target protein, and lay a solid foundation for subsequent research on protein structure and function.
Second, PMSF is also indispensable in the investigation of enzyme kinetics. Researchers can use PMSF's inhibitory effect on specific proteases to observe the changes in enzymatic reaction rate, substrate affinity and other parameters in detail. By precisely controlling the concentration and action time of PMSF, the mechanism of protease action is deeply analyzed, which contributes to the improvement of enzymatic theory.
Third, PMSF plays an important role in the preparation of high-purity protein preparations. In many steps of protein extraction and purification, endogenous proteases are always a hidden danger affecting protein purity and activity. PMSF can effectively inhibit these proteases, greatly improve the purity and quality of protein preparations, and provide strong support for the output of high-quality products in the fields of pharmaceutical research and development, biological product production, etc.
PMSF occupies a pivotal position in the field of protease-related research and protein-related product preparation due to its unique chemical properties, paving a solid path for the development of life science research and related industries.

What is the mechanism of action of Phenylsulfonylfluoride?

Fuphenyl sulfonyl fluoride, in the field of biochemistry, has different functions, and its mechanism of action is also profound. This is a powerful inhibitor of serine protease.
Serine protease, a family of enzymes, plays a key role in many physiological processes, such as coagulation, fibrinolysis, complement activation, digestion, etc. Its active center contains serine residues, which are nucleophilic, capable of nucleophilic attack and enzymolysis with the substrate peptide bond carbonyl carbon.
Phenyl sulfonyl fluoride molecule contains a sulfonyl fluoride group, the fluorine atom in this group has strong electronegativity, making the sulfur atom strong electrophilicity. When phenyl sulfonyl fluoride meets serine protease, the sulfonyl fluoride group can irreversibly covalently bind to the hydroxyl group of serine residue in the active center of the enzyme. This covalent binding process begins with the nucleophilic attack of the serine hydroxyl oxygen atom on the sulfonyl fluoride sulfur atom, and the fluoride ion leaves to form a stable thioester bond. After this binding, the active center structure of the enzyme is destroyed, and the substrate cannot bind and catalyze normally, so the enzyme activity is inhibited. From this perspective, phenyl sulfonyl fluoride can inhibit the activity of serine protease through the mechanism of irreversible covalent binding with serine residues in the active center of serine protease, which is a powerful tool for regulating physiological processes and studying enzyme functions. It is also of great value in the fields of biochemical research and medicine.

Phenylsulfonylfluoride what are the precautions during use

Fuphenyl sulfonyl fluoride, the material used for chemical use, must be careful when using, the following things must not be ignored.
First, its highly toxic, once touched, or through the skin, or by breathing, can cause harm. Therefore, when using, it is necessary to wear protective equipment, such as a gas mask, which can protect its toxins from entering the breath; protective gloves, which can be separated from the skin; and protective clothing, which protects the whole body to prevent toxins from sticking to the body.
Second, phenyl sulfonyl fluoride is active and easy to react in a specific environment. Or unstable in case of heat, or contact with other things and change. Therefore, it is necessary to choose a cool, dry and ventilated place for storage, and it is far away from fire and heat sources, and it should not be stored and transported together with taboo things to prevent unexpected changes.
Furthermore, the place where it is used should be equipped with a perfect ventilation device. It can lead in fresh air, drain the poison of filth and turbidity, reduce its concentration in the air, and reduce the harm to the invisible. If there is any carelessness, it will cause it to leak, and the unrelated person will be removed immediately, and the operator will deal with it with protection. Small leaks will be sucked up with sand and the like, and large leaks will be surrounded by embankments for special places.
Also, when using finished utensils, it should not be discarded lightly, and it must be dealt with according to regulations. Because of its residual poison, if it is discarded at will, it will pollute the soil and water sources, causing a wide range of harm. And the person who uses it must be aware of its risks and know its solutions before acting. In this way, only when using phenylsulfonyl fluoride can it be safe.

How safe is Phenylsulfonylfluoride?

Phenyl sulfonyl fluoride (Phenylsulfonylfluoride) is also a chemical reagent, which is very useful in biochemical experiments. However, its safety is a top priority and cannot be ignored.
Phenyl sulfonyl fluoride is toxic and can harm the body through inhalation, ingestion and skin contact. When it enters the lungs, it can cause coughing, difficulty breathing, and even pulmonary edema, which endangers life. If it enters the gastrointestinal tract, it may cause nausea, vomiting, and abdominal pain, which can damage the digestive system. If it touches the skin, it can cause inflammation and allergies, burning and itching. If it encounters the eye, it can hurt the eyes and cause visual impairment.
Its chemical activity is lively, and it is dangerous to explode in case of heat or open flame. When mixed with oxidizing agents, it can cause a strong reaction, so it is necessary to avoid such substances when storing and transporting.
When used in the laboratory, all protective measures must be taken. Operators should wear protective clothing, goggles and gloves in a well-ventilated place to prevent the gas from dispersing in the room. If they accidentally touch it, quickly flush it with a lot of water, and the injured will seek medical attention.
In short, although phenyl sulfonyl fluoride is useful in experiments, it is toxic and dangerous, so it must be operated in accordance with regulations, heavy protection, and safety, so as to avoid disasters before they occur, and use it in the right way.

What are the advantages of Phenylsulfonylfluoride compared to other similar products?

Fuphenyl sulfonyl fluoride has many unique advantages among various similar products. The best thing about it is its high reactivity. Compared with others, phenyl sulfonyl fluoride can participate in many chemical reactions more quickly and efficiently, just like a sharp blade breaking bamboo, smooth and unimpeded, which can greatly accelerate the reaction process and improve the yield.
Furthermore, its selectivity is quite good. Like a discerning person, it can accurately select a specific reaction check point, and above this check point, launch a specific reaction without disturbing other places, thus greatly reducing the occurrence of side reactions, increasing the purity of the product, and alleviating the difficulty of subsequent separation and purification.
And the stability of phenylsulfonyl fluoride is also a major highlight. Under normal storage and operating conditions, its properties are as stable as Mount Tai, and it is not easy to decompose and deteriorate, so it can ensure the continuity and reliability of the experiment and production process without worrying about its inactivation.
And its application range is extremely wide. Whether it is in the field of organic synthesis, biomedicine, or even materials science, it can be found. It can be used in many different systems and reaction conditions, such as a universal key, which can open many doors. This is the advantage of phenylsulfonyl fluoride compared to other similar products.