Para-Toluenesulfonyl Fluoride

Duxiu Chemical

Specifications

HS Code	992799
Name	Para - Toluenesulfonyl Fluoride
Chemical Formula	C7H7FO2S
Molar Mass	174.19 g/mol
Appearance	Colorless to light - yellow liquid
Odor	Pungent odor
Density	1.22 g/cm³
Boiling Point	145 - 146 °C at 15 mmHg
Melting Point	−32 °C
Solubility	Insoluble in water, soluble in organic solvents like dichloromethane, chloroform
Flash Point	107 °C
Stability	Stable under normal conditions, but reactive with strong bases and nucleophiles

As an accredited Para-Toluenesulfonyl Fluoride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of Para - Toluenesulfonyl Fluoride in a sealed, chemical - resistant bottle.
Storage	Para - Toluenesulfonyl Fluoride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and incompatible substances like strong bases and reducing agents. Store in a tightly - sealed container to prevent moisture and air exposure, which could lead to decomposition. Ensure storage is in a place with proper safety equipment in case of spills.
Shipping	Para - Toluenesulfonyl Fluoride is shipped in tightly sealed, corrosion - resistant containers. It must be transported under cool, dry conditions, adhering to strict chemical shipping regulations to prevent any leakage or safety hazards.

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General Information

Historical Development

The industry of chemical industry is changing with each passing day. There is a thing called Para - Toluenesulfonyl Fluoride, which has a lot of functions in various fields. Tracing its origin, researchers at the beginning were exploring new chemical products when they accidentally came across it. At that time, but seeing its strange characteristics, they delved into it.
After years have passed, various scholars have made unremitting explorations to clarify its structure and nature. Therefore, the use of this product has become more and more widespread, and it can be a wonderful agent in the production of medicine; in the production of materials, it can help good materials. Its development also depends on the painstaking efforts of the researchers since the beginning of ignorance and the familiarity to this day. Only then can they move forward step by step and make remarkable achievements, adding a brilliant chapter to the history of chemical industry.

Product Overview

In the field of chemical industry, there is the name Para - Toluenesulfonyl Fluoride, which has a wide range of uses. This material is pure in color and pure in quality, and is often emphasized in the chemical industry.
In the process of organic synthesis, it can be used as a sulfonylation agent, which can add sulfonyl groups to various substances to change their properties and enlighten new chemical paths. In the context of pharmaceutical creation, it also has remarkable achievements, helping to form the structure of various drugs, increasing their effectiveness and stabilizing their properties.
Looking at the method of its preparation, it is fine and dense. After various reactions, temperature control and pressure regulation can be used to obtain high-purity products. Although preparation is not easy, its effect is significant, so it is sought by researchers. Practicing in industry, it also gradually develops its capabilities and contributes to the advancement of chemical industry.

Physical & Chemical Properties

Today there is a substance named Para Toluenesulfonyl Fluoride. Its physical and chemical properties are particularly important, and it has been studied by many. This substance is pure and transparent in color. If it is clear water, it is often in a liquid state, and it is stable in the chamber. Its boiling point is quite high, and it has a certain degree of volatility. Under specific temperature and pressure, it can be a gas phase.
In terms of chemistry, its activity is unique and it can react with various substances. In contact with alkalis, it can form new compounds, and its bonds are wonderful. Chemists study it. In the field of organic synthesis, it is an essential agent, helping to form a variety of complex structures, such as artisan tools, and skillfully made high-quality products. And the balance between its stability and reactivity is also of great importance to researchers, in order to understand its wide range of uses, to explore the depth of its rationale, and to gain more progress in the process of science.

Technical Specifications & Labeling

Today there is Para - Toluenesulfonyl Fluoride, and its technical specifications and labels (commodity parameters) are very important. To look at its quality, it needs to be pure and free of impurities, with a clear color and taste. The number of measurements must be in line with accurate regulations, the amount of content, and the geometry of impurities are all fixed.
The method of testing should follow a strict order. Measuring its spectrum with an instrument and observing its peaks and valleys can tell that its structure is certain. Measuring its melting point and boiling point, observing the change of its phase state can also prove its purity. On the logo, the name must be accurate, the origin, batch, and date must be detailed, and the method of use and the items of attention cannot be omitted. In this way, the good products of Para-Toluenesulfonyl Fluoride can be satisfied with all kinds of usage.

Preparation Method

To make Para Toluenesulfonyl Fluoride, the raw materials and production process are very critical. The raw materials need to be carefully selected to ensure the purity of the quality. In the production process, the reaction steps are particularly important. First take p-toluenesulfonyl chloride and mix it with the fluorinating agent in an appropriate proportion. Place the two in a special container and control the appropriate temperature and pressure to make it fully react. During the reaction process, various parameters must be carefully observed to fine-tune in a timely manner to ensure a smooth reaction. As for the catalytic mechanism, a specific catalyst can be introduced to accelerate the reaction rate and increase the yield. This catalyst can change the chemical reaction path, reduce the activation energy, and make the reaction proceed efficiently. In this way, following this process, it is expected to obtain high-quality Para Toluenesulfonyl Fluoride products.

Chemical Reactions & Modifications

In the field of chemical industry, there is a thing called Para - Toluenesulfonyl Fluoride. Its response to chemistry is especially important. At the beginning, the reaction rate of this compound mostly followed the old rules, although it was effective, it also had limitations.
All the sages worked hard and thought about the change. So they researched new methods to change its nature. Either adjust the temperature of the reaction, or use the agent easily, hoping to get the best effect. After repeated tests, they achieved amazing results.
The nature of its reaction is much different from that of the past. The reaction that was difficult to achieve in the past is now smooth; those that took a long time in the past are now quick. This change is like a rain in a dry field in the chemical industry, and it benefits a lot. And Para - Toluenesulfonyl Fluoride, also because of its ability, in various fields, shines brightly, for the progress of chemical industry, add bricks and mortar, contribution.

Synonyms & Product Names

I've heard of Para Toluenesulfonyl Fluoride. Its name may be another name, and its business name may be different. In my chemical research, I know that it is common to have the same name and different name. It may be commensurate with a common name, or it may be named according to its nature and use. In the research of this substance, it often encounters the same reference but different name. Although the names are different, its quality is one. Like all things, there are many names, but the origin is Para Toluenesulfonyl Fluoride. The establishment of the business name may be unconventional and attract attention; the name of the different name may be different from the region and habit. But for the researcher, it should be clear about its quality, not because of the name, and focus on its nature and use, in order to achieve the purpose of research.

Safety & Operational Standards

There are chemical substances today, called Para - Toluenesulfonyl Fluoride, which is the key to safety and operation standards in experiments.
This substance has certain chemical activity, so when storing, it should be stored in a cool, dry and well-ventilated place. It is advisable to avoid open flames and hot topics to prevent accidents. And it must be stored in isolation from oxidants, alkalis, etc., and must not be mixed to avoid chemical reactions and endanger safety.
When taking it, it is necessary to strictly abide by the operating procedures. Experimenters must prepare protective equipment, such as protective glasses, gloves, protective clothing, etc., to prevent it from touching the skin and eyes. The operation should be carried out in the fume hood to allow the harmful gas to be discharged in time to avoid the inhalation of the experimenter.
If you accidentally come into contact with this substance and touch the skin, you should quickly rinse with a large amount of flowing water for at least fifteen minutes, and then seek medical treatment. Those who enter the eyes should also be rinsed with a large amount of water or normal saline immediately, and again for not less than fifteen minutes, and then seek medical attention.
During the reaction process, the reaction conditions, such as temperature, pressure, and the proportion of reactants, should be precisely controlled. Due to changes in conditions, or the reaction may be out of control, causing danger. After the experiment is completed, the remaining materials and waste should not be discarded at will, and should be properly disposed of in accordance with regulations to prevent environmental pollution.
In conclusion, when dealing with Para-Toluenesulfonyl Fluoride, only by abiding by safety and operating standards can we ensure the smooth operation of the experiment, protect the safety of personnel, and maintain the safety of the environment.

Application Area

In recent times, chemical techniques and various compounds have emerged, among which Para - Toluenesulfonyl Fluoride has a wide range of uses. In the field of biochemistry, it can make enzyme inhibitors to study the function of enzymes and help solve the mystery of life mechanism. In the field of materials, it can adjust the properties of materials to make them have special qualities, such as increasing their toughness and changing their appearance. In pharmaceutical research and development, it can be a key reagent, participating in the synthesis of drugs, and finding a cure for diseases. Therefore, Para - Toluenesulfonyl Fluoride has extraordinary effects in many application fields, and is actually an indispensable thing for chemical research and industrial development.

Research & Development

With the progress of modern chemistry, Para - Toluenesulfonyl Fluoride has gradually become more and more important in the academic community. We dedicated ourselves to studying, observing its physical properties and chemical properties, and studying its preparation methods in detail. At the beginning, the preparation technique was not good, the yield was quite low, and there were many impurities. However, we continued to explore, improve the process, add new agents, control the temperature and speed, the yield gradually increased, and the purity was also good.
And consider its application, in the field of organic synthesis, it can be used as a medium for reactions, making various reactions efficient and accurate. In pharmaceutical research and development, it may be used as an active ingredient to treat various diseases. Although progress has been made, the road ahead is still long. In the future, we should expand the breadth of its application and deepen the depth of its research, with the hope of contributing to the development of chemistry and the well-being of mankind, and promoting its continuous evolution and brilliance.

Toxicity Research

Taste the wonders of medicine, it is related to life; the nature of medicinal stones cannot be ignored. Today there is Para Toluenesulfonyl Fluoride, which is an important matter in toxicity research.
Para Toluenesulfonyl Fluoride, its nature may be invisible, but it has a far-reaching impact. Taste it, its entry into the body, or disturb the circulation of qi and blood, messing with the order of the viscera. Although there is no trace to be found, the appearance of toxicity can cause fatigue and tiredness, and the viscera are in violation.
Toxicity research should be investigated in detail. Observe its interaction with qi and blood, and observe its invasion of the viscera. Using the ancient law, it should be rigorous, and it must be investigated. Examining its behavior in the body carefully can reveal the true meaning of its toxicity, which is the foundation for medical medicine and protection, to ensure the well-being of everyone, and to avoid the harm of toxicity.

Future Prospects

Looking forward to the future, in Para - Toluenesulfonyl Fluoride, there are many promising products. Its chemical properties can be used as an efficient tool to develop a new synthesis path. It is not possible to make a big impact in the field of research and development, and its characteristics help to develop more effective and less side effects. It is also expected to make breakthroughs in the field of materials science, improve the performance of materials. And with the refinement of technology, the production and manufacturing can be improved, the cost can be reduced, and the application of this product can be more extensive. In addition, Para - Toluenesulfonyl Fluoride has not been developed, and it is possible to fill the limit, and it is necessary to make a new revolution in the field of transformation.

Where to Buy Para-Toluenesulfonyl Fluoride in China?

As a trusted Para-Toluenesulfonyl Fluoride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading Para-Toluenesulfonyl Fluoride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of Para-Toluenesulfonyl Fluoride?

Para-toluenesulfonyl fluoride (Para-Toluenesulfonyl Fluoride) has a wide range of uses. In the field of organic synthesis, it is often used as a sulfonylation reagent. Gein sulfonyl groups have unique chemical properties and can participate in many reactions, such as meeting alcohols and forming sulfonate esters under specific conditions. This product is often a key intermediate in the organic synthesis step, helping to build complex organic molecular structures.
In the field of pharmaceutical chemistry, it is of great significance. Pharmaceutical developers can use it to react with compounds containing hydroxyl groups and amino groups to introduce sulfonyl groups, which can greatly change the physical and chemical properties of drug molecules, such as solubility, stability, and biological activity, thereby helping to create new drugs with better efficacy and fewer side effects.
In the field of materials science, p-toluenesulfonyl fluoride is also useful. For example, in the modification of polymer materials, using it as a modifier can introduce sulfonyl fluoride groups on the surface of polymer materials, thereby improving the surface properties of materials, such as wettability, adhesion, etc., so that the material can be better applied in coatings, adhesives and other fields.
Furthermore, in some catalytic reaction systems, p-toluenesulfonyl fluoride can be used as an additive, which affects the rate and selectivity of the reaction, provides assistance for the efficient operation of catalytic reactions, and promotes more efficient processes such as chemical production. In short, p-toluenesulfonyl fluoride plays an important role in various fields, promoting technological development and innovation in various fields.

What are the chemical properties of Para-Toluenesulfonyl Fluoride?

Para - Toluenesulfonyl Fluoride, Chinese name p-toluenesulfonyl fluoride, is an important compound in organic chemistry. It has many unique chemical properties, and this is the beginning.
The nucleophilic substitution reaction is first described. The sulfonyl fluoride group in this substance is extremely active, and the fluorine atom is easily replaced by various nucleophiles. In case of alcohols, nucleophilic substitution can occur, and the fluorine atom leaves to form p-toluenesulfonate compounds. This reaction is often used in organic synthesis to introduce a sulfonate group, which can be used as a good leaving group in subsequent reactions to help construct carbon-carbon bonds or carbon-heteroatomic bonds.
The reaction with amines is discussed again. P-toluenesulfonyl fluoride can react with amines to form sulfonamide products. This reaction is of great significance in the field of drug synthesis. Sulfonamide structures are commonly found in many drug molecules, giving drugs unique biological activities and physicochemical properties.
Furthermore, under basic conditions, the sulfonyl fluoride group of p-toluenesulfonyl fluoride can hydrolyze to form p-toluenesulfonic acid and its salts. The rate of this hydrolysis reaction is affected by factors such as temperature and alkali concentration. Reasonable regulation of these conditions can effectively control the reaction process.
In addition, because its structure contains benzene rings, p-toluenesulfonyl fluoride can also participate in aromatic ring-related reactions, such as the Fu-gram reaction, etc., whereby its molecular structure can be modified and expanded to synthesize more complex organic compounds.
In short, p-toluenesulfonyl fluoride plays an important role in organic synthesis, pharmaceutical chemistry and other fields due to its active sulfonyl fluoride group and stable benzene ring structure. Chemists often use its chemical properties cleverly to achieve the construction and functionalization of various complex organic molecules.

What are the precautions for storing Para-Toluenesulfonyl Fluoride?

Para - Toluenesulfonyl Fluoride (p-toluenesulfonyl fluoride, referred to as TSF) is a very important reagent in organic synthesis. When storing it, there are several ends that need to be paid attention to.
First, pay attention to its chemical properties. TSF has active chemical properties and easily reacts with compounds containing active hydrogen such as water and alcohol. If it is stored, it must be kept dry, away from water sources and moisture, to avoid side reactions such as hydrolysis. If it is accidentally damp, its chemical activity will be damaged, or the experimental results will not meet expectations.
For the second time, temperature is also the key. TSF should be stored in a cool place, usually at 2-8 ° C. Excessive temperature can promote its decomposition or accelerate its reaction with substances in the environment. In case of high temperature, its molecular structure may be damaged, making it impossible to exhibit its due chemical activity during the experiment.
In addition, the storage container must also be carefully selected. Corrosion-resistant containers, such as glass or specific plastic materials, should be used. Glass containers are chemically stable and not easy to react with TSF; specific plastic materials should also be ensured not to interact with TSF, so as not to cause pollution to TSF and affect its quality.
In addition, the storage environment should avoid coexistence with strong oxidants, strong alkalis and other substances. It is dangerous because it encounters with strong oxidants or causes violent oxidation reactions; when it comes into contact with strong alkalis, it is prone to reactions such as saponification, resulting in its failure.
And TSF is toxic, and it should be well ventilated when stored to prevent its volatile gas from accumulating in the environment and endangering human health. After taking it, be sure to seal the container properly to prevent it from coming into contact with outside air and causing quality deterioration.

What are the synthesis methods of Para-Toluenesulfonyl Fluoride?

The synthesis method of Para - Toluenesulfonyl Fluoride (p-toluenesulfonyl fluoride, referred to as TOSF) has always been an ancient method. In the past, one of the methods for synthesizing this substance was to react with p-toluenesulfonyl fluoride together with a fluorinating agent. First take p-toluenesulfonyl fluoride and place it in a suitable reaction vessel. This container needs to be clean and dry to prevent impurities from disturbing it. Next, slowly add fluorinating agents. Fluorinating agents, such as potassium fluoride and sodium fluoride, should be added in proportion. The proportion is accurate, and the effect of the reaction is related. After the injection is completed, stir to mix the two thoroughly, and control the reaction temperature. Usually in the heated state, the temperature may be between 50 and 80 degrees Celsius, depending on the specific situation. In this process, it is necessary to closely observe the reaction signs, such as the escape of bubbles and the change of color.
Another method is to use toluene as the starting material. First, the toluene and the sulfonating agent are used. The sulfonating agent is often concentrated sulfuric acid and the like. Under specific conditions, the two play a sulfonation reaction, and the p-toluenesulfonic acid intermediate can be obtained. Then, the intermediate is reacted with a fluorinating reagent, such as phosphorus pentafluoride and other fluorinated reagents, in a suitable solvent environment, such as dichloromethane and other inert solvents, and stirred again to make the reaction sufficient, and finally the p-toluenesulfonyl fluoride is obtained.
When synthesizing, many details need to be paid attention to. The reaction vessel, the purity of the raw materials, the temperature, time and stirring rate of the reaction all have a great influence on the yield and purity of the product. Only by carefully controlling all the factors can the synthesis go smoothly and a satisfactory product can be obtained.

Para-Toluenesulfonyl safety risks during the use of Fluoride

During the use of Para-Toluenesulfonyl Fluoride (p-toluenesulfonyl fluoride, referred to as TOSF), there are many safety risks that need to be treated with caution.
TOSF is highly corrosive, and when touched, it can cause severe pain to the skin, just like a fire burning the body, and the injury may be red, swollen, and blisters, which are difficult to heal for a long time. If it is not carefully entered into the eyes, it is particularly harmful, and it can damage the tissues of the eyes, which can cause eye pain, tears, blurred vision, and blindness.
Its volatile gas is also a hidden danger. Inhaling this gas can irritate the respiratory tract, causing coughing, asthma, and even causing breathing difficulties and damage to the lungs. Long-term exposure to this environment may increase the risk of respiratory diseases and even lung diseases.
Furthermore, TOSF is chemically active and can react violently in contact with water or moisture, releasing harmful gases such as hydrogen fluoride. This gas is not only pungent, but also highly corrosive, posing a threat to the surrounding environment and personnel. Encounters with alkali, oxidants and other substances may also trigger dangerous reactions, such as combustion, explosion, etc., endangering personal and property safety.
Therefore, when using TOSF, protective measures must be comprehensive. In front of protective clothing, such as armor, wear protective gloves, keep your hands safe, wear protective glasses and respirators, and protect your eyes and breathing. The operation should be carried out in a well-ventilated place. If there is any leakage, it should be dealt with promptly according to the regulations. Do not slack off to avoid disasters.