P-Toluenesulfonyl Fluoride

Duxiu Chemical

Specifications

HS Code	794314
Chemical Formula	C7H7FO2S
Molar Mass	174.19 g/mol
Appearance	white to off - white solid
Melting Point	66 - 69 °C
Boiling Point	145 - 146 °C at 10 mmHg
Solubility In Water	insoluble
Solubility In Organic Solvents	soluble in common organic solvents like dichloromethane, chloroform
Density	1.324 g/cm³
Vapor Pressure	low vapor pressure
Pka	very acidic (sulfonyl fluoride group)
Flash Point	110 °C
Stability	stable under normal conditions but reactive with nucleophiles

As an accredited P-Toluenesulfonyl Fluoride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	P - Toluenesulfonyl Fluoride, 100g in a tightly - sealed, chemical - resistant bottle.
Storage	P - Toluenesulfonyl fluoride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent moisture absorption and vapor leakage. This helps maintain its chemical stability and reduces the risk of potential hazards.
Shipping	P - Toluenesulfonyl Fluoride is a hazardous chemical. Shipping requires proper packaging in accordance with regulations, likely in sealed, corrosion - resistant containers, and transported with appropriate safety documentation by approved carriers.

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General Information

Historical Development

P-Toluenesulfonyl Fluoride is an important reagent in organic synthesis. Its origin can be traced back to the gradual development of chemical research. At the beginning, scholars explored new sulfonylation reagents, and after many attempts, they obtained this compound.
In the early days, the synthesis method was still simple, and the yield was not ideal. However, with the advance of chemical technology, new synthesis paths gradually emerged, and the yield and purity increased. Its application is also widespread, and it has traces in the fields of medicinal chemistry and materials science. In medicine, it helps to form key drug intermediates; in materials, it participates in the creation of special materials. From this perspective, P-Toluenesulfonyl Fluoride has been around since its inception, and has made steady progress in the long river of chemical development. Its role has become increasingly apparent, making great contributions to scientific research and industry.

Product Overview

P-Toluenesulfonyl Fluoride is an important agent in organic synthesis. If it is a colorless to slightly yellow liquid, it has a specific odor. This substance has a wide range of uses in the field of organic chemistry. It is often used as a sulfonylation reagent and can react with many nucleophiles to introduce p-toluenesulfonyl groups.
Its reactivity is very high, and it can convert alcohols into p-toluenesulfonyl sulfonates. This ester compound is extremely useful in nucleophilic substitution and elimination reactions. In the field of peptide synthesis and other fields, P-Toluenesulfonyl Fluoride is also used to help form peptide bonds. However, it has certain toxicity and corrosiveness. When using, strictly follow the operating procedures to ensure safety. When preparing, rigorous chemical processes are required to control temperature and pressure in order to obtain high-purity products.

Physical & Chemical Properties

P - Toluenesulfonyl Fluoride is also a chemical substance. Its properties are both physical and chemical. As far as physical properties are concerned, under normal conditions, its properties are solid and have a specific melting property. This melting property is an important physical property, which can help to improve the properties of fluoride. And its external properties or have a specific color and shape.
And chemical properties, P - Toluenesulfonyl Fluoride has anti-activity. It can generate and react with many chemical compounds. For example, compounds containing a chemical group can be substituted and reversed to form new derivatives. This anti-chemical property has a wide range of uses in the field of synthesis, and can be used as an important synthesis process. It can help to synthesize the molecules of the industry and promote the synthesis of synthetic technology.

Technical Specifications & Labeling

Nowadays, there is a chemical product called P-Toluenesulfonyl Fluoride. Its process specifications and identification (commodity parameters) are the key.
The process specifications are related to the preparation of this product. From the selection of raw materials, it is necessary to be pure and fine, and impurities should not enter. The reaction conditions, temperature and pressure need to be precisely controlled, and the reaction time should also be appropriate. If it is too long, it will be too long, and if it is short, it will not be fully completed.
In terms of identification, the product parameters should be detailed. The proportion of its ingredients must be clearly marked to make it clear to people at a glance. The appearance, color, shape, etc. should be confirmed. The description of the use is also indispensable to inform people where this product is suitable to avoid the risk of misuse. In this way, the gist of P-Toluenesulfonyl Fluoride process specifications and labels is obtained.

Preparation Method

P-Toluenesulfonyl Fluoride is made today, and its raw materials, production process, reaction steps, and catalytic mechanism are the key. Take toluene, sulfonate it, and heat it with concentrated sulfuric acid to obtain p-toluenesulfonic acid. Then it is chlorinated with acyl and reacted with sulfoxide chloride to obtain p-toluenesulfonyl chloride. Then it interacts with a fluorinating agent, and uses an appropriate amount of potassium fluoride as an agent to react at a suitable temperature and duration. In this process, the control of reaction conditions is very important. Temperature, pressure, and the ratio of reactants are all related to yield and purity. In the catalytic mechanism, or with a specific catalyst, the reaction process is accelerated to make the reaction efficient and orderly, so that high-quality P-Toluenesulfonyl Fluoride can be obtained.

Chemical Reactions & Modifications

P-Toluenesulfonyl Fluoride, in the field of chemistry, its reaction and modification are worth exploring. Past studies were mostly confined to conventional paths, but if you want new changes, you must think of other ways.
Looking at its reaction, it often follows a fixed formula. If you want to get specific results, you need to adjust the conditions. Or change the temperature, or easy to solvent, in the hope that it can trigger other reactions. The change of temperature can change the molecular activity; the difference of solvent can adjust the reaction environment.
As for modification, it is necessary to increase its utility. Or introduce new radicals and change its structure to adapt to more scenarios. Although the road ahead is difficult, the beauty of chemistry is here. With unremitting exploration, with time, we will be able to obtain a new appearance through the reaction and modification of P-Toluenesulfonyl Fluoride, which will add to the progress of chemistry.

Synonyms & Product Names

P Toluenesulfonyl Fluoride, in the field of chemical industry, has various synonymous names and commodity names. Its synonymous names, such as p-toluenesulfonyl fluoride, are derived from its chemical structure and composition. In inter-market trade, it also has the name of a specific commodity and is well known in the industry.
p-toluenesulfonyl fluoride, its active nature, in the organic synthesis industry, often used as a key reagent. It can react with many compounds and help create new substances. Looking at the development of chemical industry in ancient times, such reagents are gradually emerging and are valued by craftsmen. With its unique characteristics, it guides the direction in the reaction and makes the synthesis smoother. In today's chemical industry, p-toluenesulfonyl fluoride is circulated under the name of different commodities, but its essence is the same, and it is an important angle to promote the progress of chemical industry. In the art of synthesis, it continues to develop its capabilities.

Safety & Operational Standards

P toluenesulfonyl fluoride is an important substance in chemical research. Its safety and operating standards are related to the smooth progress of the research and the well-being of personnel, and cannot be ignored.
In terms of safety, this substance is toxic to a certain extent, and it can endanger the human body by contact or inhalation. Therefore, when operating, be sure to wear protective clothing, protective gloves and goggles to prevent skin and eye contact. And should work in a well-ventilated place, or with the help of ventilated equipment, to avoid inhaling its volatile gas.
As far as the operating specifications are concerned, when using clean and dry utensils, beware of impurities mixed in. Weighing must be accurate, and careful operation should be performed according to the amount required for the experiment. The dissolution process should also be paid attention to. A suitable solvent should be selected according to its characteristics, and stirred moderately to promote its full dissolution.
Storage is also critical. It should be placed in a cool, dry and ventilated place, away from fire sources and oxidants. Storage containers must be well sealed to prevent leakage and deterioration.
In the disposal of waste, it must not be discarded at will. Relevant environmental protection regulations should be followed, and proper disposal should be carried out to prevent environmental pollution.
On the road of chemical research, the safe and standardized operation of P toluenesulfonyl fluoride is a must-observe principle for researchers, so as to ensure the safety and order of research and achieve the expected results.

Application Area

P-Toluenesulfonyl Fluoride is also a chemical compound. Its application domain is particularly interesting in biochemical research. In protein research, it can inhibit the activity of aminoprotease, in order to maintain the function of protein. In the field of research, it helps researchers explore the action of enzymes, create new targets, and promote new production. In the field of chemical synthesis, it can be used as sulfonylation, introducing sulfonyl groups into molecules, expanding compounds, and increasing their characteristics. In addition, P-Toluenesulfonyl Fluoride has its specialization in biochemistry, chemistry, chemical synthesis, etc., all of which have shown extraordinary functions and promoted the development of the first step.

Research & Development

Today there is a substance called P-Toluenesulfonyl Fluoride. As a chemical researcher, I have devoted myself to studying this substance for a long time. Its properties are unique and it has a wide range of applications.
In the process of research, study its structure and characteristics in detail, explore the reaction mechanism, and hope to gain insight into its mysteries. After repeated experiments and analysis, some gains have been made.
Looking at its development, it has broad prospects. It can be used in many fields, such as pharmaceutical synthesis, which can help the research and development of new drugs; in materials science, or it can improve the properties of materials. We should make unremitting research to expand its application and tap its potential. Strive to improve technology, improve quality, and make it shine in various fields, adding bricks and tiles to the development of scientific research and industry, so as to achieve new territory.

Toxicity Research

Since modern times, chemical refinement, all kinds of products have been produced one after another. Today there is P Toluenesulfonyl Fluoride, which may have its uses in various karma, but the investigation of its toxicity cannot be ignored.
If you want to explore its toxicity in detail, you must use scientific methods to observe its response to things and its effect on life. Observe its entry into the body, follow what path, change, and damage to the viscera and meridians. It is also placed in different environments, depending on its change, to observe the strength of its poison.
The investigation of toxicity is related to the well-being of the people and the stability of the industry. Only by specifying its toxicity can you act with caution, use it wisely, avoid harm and pursue profit, and ensure the safety of the human environment. Therefore, the research on the toxicity of P Toluenesulfonyl Fluoride, when all efforts are made, it is actually a lesson for the world.

Future Prospects

Looking at the world today, science and technology are changing day by day, and chemical substances are also rejuvenating. P-Toluenesulfonyl Fluoride, although small, is widely used and wonderful. Today, it can be a key agent in pharmaceutical research and development, helping doctors solve difficult diseases; in materials science, it can be the key to innovation and open the door to new materials.
Looking to the future, P-Toluenesulfonyl Fluoride will surely shine. In the field of medicine, it may be able to generate miraculous new drugs and save thousands of patients from pain; in the field of materials, it may be able to create extraordinary materials, which meet the needs of all parties. Its development path, although there may be twists and turns, but the prospects are shining, such as the rising sun, its light will be able to shine everywhere, contribute to human well-being, and achieve extraordinary things.

Where to Buy P-Toluenesulfonyl Fluoride in China?

As a trusted P-Toluenesulfonyl Fluoride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading P-Toluenesulfonyl Fluoride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of P-Toluenesulfonyl Fluoride?

P-Toluenesulfonyl Fluoride (p-toluenesulfonyl fluoride) is a commonly used reagent in organic synthesis. Its main uses can be roughly divided into the following numbers.
First, it is very important for the conversion of alcohols. P-toluenesulfonyl fluoride can react with alcohols to form p-toluenesulfonate esters. This ester compound has a significant increase in reactivity compared with original alcohols and can act as an intermediary in many nucleophilic substitution reactions. Because p-toluenesulfonyl oxide is an excellent leaving group, it is convenient for nucleophiles to attack, so as to realize the substitution conversion of alcohol hydroxyl groups, such as the synthesis of halogenated hydrocarbons.
Second, it is also useful for the modification of amine compounds. P-toluenesulfonyl fluoride can react with amines to form sulfonamides. This process can not only be used to protect the amine group from the interference of other reagents; and under specific conditions, the sulfonamide can remove the protective group by appropriate methods to restore the activity of amines. This provides great convenience in the planning of synthesis steps of complex organic molecules, ensuring that the reaction proceeds according to the predetermined route.
Third, p-toluenesulfonyl fluoride contributes a lot to the construction of carbon-heteroatomic bonds. It can participate in a variety of catalytic reaction systems and promote the formation of chemical bonds between carbon and heteroatoms such as nitrogen and oxygen. This is crucial in the field of medicinal chemistry when synthesizing molecules with specific biological activities. The skeleton construction of many drug molecules often relies on such reactions to precisely construct the required molecular structure through the reaction steps involving p-toluenesulfonyl fluoride to meet the requirements of drug activity and finished drugs.

What are the Physical Properties of P-Toluenesulfonyl Fluoride

P-Toluenesulfonyl Fluoride, that is, p-toluenesulfonyl fluoride, has many characteristics in its physical properties. Under normal conditions at room temperature, it is mostly colorless to light yellow liquid, and it looks clear, like autumn water. Its smell is special, although not pungent and intolerable, it is also distinctly recognizable, like a faint fragrance, hidden in it.
The boiling point of p-toluenesulfonyl fluoride is quite noteworthy, about a specific temperature range. This boiling point characteristic allows it to realize the transformation of gas and liquid under specific conditions. The melting point is also in the corresponding range. When the external temperature drops below the melting point, it gradually solidifies from liquid to solid, just like winter water freezes into solid ice.
Its density is moderate, and it occupies a specific proportion in the same type of compounds. And solubility is also one of the important physical properties. In some organic solvents, such as alcohols and ether solvents, it shows good solubility, just like fish in water, and they blend seamlessly; however, in water, its solubility is relatively limited, like oil and water, and it is difficult to completely blend.
The physical properties of p-toluenesulfonyl fluoride, such as liquid form, special odor, specific melting boiling point, moderate density and unique solubility, are intertwined, and together outline its unique physical appearance. In many fields such as chemical industry and scientific research, these characteristics play a key role, providing indispensable support for the development of related industries.

What should be paid attention to when storing P-Toluenesulfonyl Fluoride?

P - Toluenesulfonyl Fluoride is a reagent commonly used in organic synthesis. When storing, be sure to pay attention to many things.
First, this material is extremely sensitive to moisture. Cover because it is prone to hydrolysis in contact with water, causing the reagent to deteriorate and fail. Therefore, when the storage environment is kept dry, it should be placed in a dryer, and the desiccant should be changed regularly to maintain the dry environment.
Second, temperature is also a key factor. It should be stored in a cool place to avoid heat. High temperature can accelerate its chemical reaction rate and damage its stability. Generally speaking, the storage temperature should be controlled between 2-8 ° C, which can prolong its shelf life and maintain good chemical activity.
Third, it should be noted that it has certain toxicity and corrosiveness. When storing, it should be properly isolated from other items, especially not in the same room with easily reactive substances. The container must be made of corrosion-resistant materials, and it must be well sealed to prevent leakage and cause harm to the surrounding environment and personnel.
Fourth, the storage place should have good ventilation conditions. If it accidentally leaks, good ventilation can disperse the volatile gas in time, reduce the concentration of harmful substances in the air, and reduce latent risk.
In short, when storing P-Toluenesulfonyl Fluoride, the elements of drying, cooling, isolation and ventilation should not be ignored, so as to ensure its stable properties and prepare for experiments.

What are the synthesis methods of P-Toluenesulfonyl Fluoride

The synthesis of P-Toluenesulfonyl Fluoride (p-toluenesulfonyl fluoride) is a very important research content in the field of chemistry. In the past, there were many different methods for synthesis.
First, p-toluenesulfonyl is often used as the starting material. The p-toluenesulfonyl sulfonic acid is mixed with chlorinated reagents such as phosphorus pentachloride or sulfoxide chloride. During this reaction, the temperature and reaction time need to be carefully controlled. The reaction of phosphorus pentachloride with p-toluenesulfonic acid can replace the hydroxyl group in the sulfonic acid group with a chlorine atom to form p-toluenesulfonyl chloride. During the process, the conditions of the reaction system are very critical, and the temperature is too high or too low, which may affect the yield and
After p-toluenesulfonyl chloride is obtained, it is reacted with fluorinating reagents. Commonly used fluorinating reagents, such as anhydrous potassium fluoride, etc. In appropriate organic solvents, such as N, N-dimethylformamide (DMF), the two undergo nucleophilic substitution reaction, and the chlorine atom is replaced by the fluorine atom, resulting in p-toluenesulfonyl fluoride. In this step, the choice of organic solvent, the amount of fluorinating reagent, and the reaction time all have a great impact on the formation of the product.
Second, toluene is also used as the starting material. First, toluene is sulfonated, and toluene is treated with concentrated sulfuric acid or fuming sulfuric acid to obtain p-toluenesulfonic acid Then proceed according to the above steps of preparing p-toluenesulfonyl fluoride from p-toluenesulfonic acid. Although the starting material of toluene is more common and easy to obtain, the sulfonation step needs to pay attention to the concentration of sulfuric acid, reaction temperature and other conditions to prevent the occurrence of side reactions and affect the subsequent reaction and product quality.
There are also those who use p-toluenesulfonamide as raw material. The p-toluenesulfonamide is first converted into the corresponding intermediate through specific reaction conditions, and then the fluorination step is used to obtain p-toluenesulfonyl fluoride. This method requires quite high reaction conditions, and the optimization of reaction conditions in each step is extremely critical to obtain the ideal yield and purity. In conclusion, there are various methods for synthesizing p-toluenesulfonyl fluoride, and each method has its own advantages and disadvantages. It is necessary to carefully select and optimize the synthesis path according to actual needs and conditions.

What are the safety precautions during the use of P-Toluenesulfonyl Fluoride?

P-Toluenesulfonyl Fluoride (P-Toluenesulfonyl Fluoride) is a commonly used reagent in organic synthesis. During use, there are many safety issues and it must be treated with caution.
First, this substance is highly corrosive and can cause serious irritation to the skin, eyes and respiratory tract. During operation, protective clothing, protective gloves and goggles must be worn to prevent inadvertent contact. If the skin touches it, rinse it with plenty of water immediately, followed by soap; if it enters the eye, rinse it with plenty of water immediately and seek medical attention as soon as possible.
Second, P-toluenesulfonyl fluoride is easily hydrolyzed in humid air to form corrosive hydrofluoric acid and p-toluenesulfonic acid. Therefore, when storing and taking it, it is necessary to keep the environment dry, and seal the container in time after taking it to prevent it from contacting with water vapor.
Third, the reagent is toxic and can be poisoned by inhalation, ingestion or skin absorption. The operation should be carried out in a well-ventilated fume hood to prevent inhalation of its volatilized aerosols. If the operation is inadvertently inhaled, it should be quickly moved to a fresh air place to keep the respiratory tract unobstructed; if the symptoms are serious, be sure to seek medical attention immediately.
Fourth, P-toluenesulfonyl fluoride is flammable in case of open flame and hot topic, and can also react strongly in contact with oxidants. Therefore, the place of storage and use should be kept away from fire sources, heat sources and strong oxidants, and avoid vibration and impact to prevent danger.
In short, the use of P-toluenesulfonyl fluoride must strictly abide by safety operating procedures, be careful and meticulous, and stay vigilant at all times to ensure personal safety and smooth experimentation.