As a leading P-Chloro-(A,A,A-)Benzotrifluoride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of P-Chloro- (A, A, A-) -Benzotrifluoride?
P-Chloro- (A, A, A-) -Benzotrifluoride) is an important substance in organic synthesis. It has a wide range of uses and is described here.
In the field of pharmaceutical synthesis, this compound is an important intermediate. Due to its special structure, it contains fluorine atoms and chlorine atoms, which can endow drug-specific physiological activities and pharmacokinetic properties. If some antibacterial and anti-inflammatory drugs are made, p-chlorotrifluorotoluene participates in the construction of molecular skeletons. After various chemical reactions, other functional groups are introduced, and new drugs with therapeutic effects are formed. The fluorine atom can increase the lipid solubility of the drug, help it pass through the biofilm, and improve the bioavailability; the chlorine atom can change the distribution of the molecular electron cloud, affecting the ability of the drug to bind to the target.
In the synthesis of pesticides, p-chlorotrifluorotoluene also occupies an important position. With it as the starting material, a variety of high-efficiency pesticides can be prepared. Fluorine gives pesticides high activity and selectivity, which is highly destructive to pests and weeds, and is environmentally friendly and has little residue. If a fluorinated insecticide is synthesized, it can accurately act on the nerve conduction system of pests, and effectively kill insects and cause less damage to beneficial organisms.
Furthermore, in the genus of materials science, p-chlorotrifluorotoluene is also useful. Can be used as an intermediary for the synthesis After polymerization, its structural units are introduced into the polymer chain, so that the material has unique properties, such as chemical resistance, heat resistance, etc. This can be used in coatings, plastics and other industries to produce high-quality and high-performance products to meet the needs of different scenarios.
In summary, p-chlorotrifluorotoluene is a key substance in many fields such as medicine, pesticides, materials, etc., which has greatly promoted the development of various industries.
What are the physical properties of P-Chloro- (A, A, A-) -Benzotrifluoride
P- - (α,α,α - ) - trifluorotoluene, also known as p-chlorotrifluorotoluene, is an important intermediate in organic synthesis. Its physical properties are as follows:
This substance is a colorless and transparent liquid at room temperature, and it looks clear and pure, like a clear spring. The smell is special and slightly irritating, and it smells like a subtle spicy smell, but it is not strong and pungent.
The boiling point of p-chlorotrifluorotoluene is about 139-141 ° C. At this temperature, the liquid will boil happily and turn into curling steam. The melting point is about -36 ° C. When the temperature drops to this level, the originally smart liquid will gradually solidify, just as time stops, turning into a solid crystal.
Its density is about 1.379 (g/cm ³), which is heavier than water. If it is placed in one place with water, it will sink to the bottom like a stable stone. And it can smoothly dissolve with common organic solvents such as ethanol, ether, acetone, etc. The two blend, indistinguishable from each other, but it is difficult to dissolve in water, as if it is naturally separated from water.
In addition, the vapor of p-chlorotrifluorotoluene is heavier than air and will spread close to the ground, just like a soft mist spreading slowly on the surface. Its flash point is about 47 degrees Celsius, in case of open flame, hot topic is very easy to burn and explode, just like a hidden powder keg, a little careless touch with the fire source, it may cause danger, so in the process of storage and use, need to pay great attention to fire and explosion.
Is P-Chloro- (A, A, A-) -Benzotrifluoride Chemically Stable?
P-Chloro- (A, A, A -) -Benzotrifluoride, that is, p-chlorotrifluorotoluene, is chemically stable.
Looking at its structure, above the benzene ring, the chlorine atom is in the para-position with trifluoromethyl. Trifluoromethyl has strong electron absorption, which can reduce the electron cloud density of the benzene ring. As a result, the electrophilic substitution activity of the benzene ring is reduced, and it is not easy to be attacked by electrophilic reagents. For example, in the halogenation, nitrification, and sulfonation reactions of common aromatic hydrocarbon electrophilic substitution, the reaction conditions of p-chlorotrifluorotoluene are more severe and the reaction rate is slower than that of benzene.
Re-discussion on the chlorine atom, although it is an ortho-para-localized group, it has an electron-absorbing induction effect on the benzene ring due to its high electronegativity, which affects the electron cloud distribution of the benzene ring to a certain extent. However, due to its conjugation effect, in a specific reaction, it can still guide the reaction to occur in the ortho-para-site. But in general, the strong electron-absorbing action of trifluoromethyl groups dominates, which inhibits the reactivity of the whole molecule.
In addition, the C-F bond energy in p-chlorotrifluorotoluene is quite high, about 485kJ/mol, and the C-Cl bond energy is not low, about 339kJ/mol. This high bond can make the molecular chemical bond break require more energy, so under normal conditions, the substance is not prone to chemical reactions due to chemical bond break, further demonstrating the stability of its chemical properties.
Under common organic reaction conditions, if there is no specific catalyst or special reaction environment, p-chlorotrifluorotoluene can maintain its own structural stability and is not prone to significant chemical changes.
What is the production process of P-Chloro- (A, A, A-) -Benzotrifluoride?
P-Chloro -(α,α,α-)- Benzotrifluoride is p-chlorotrifluorotoluene. The preparation process is as follows:
To prepare p-chlorotrifluorotoluene, p-chlorotoluene is often used as the starting material. In a specific reaction kettle, p-chlorotoluene is preheated to a suitable temperature. This temperature needs to be precisely regulated according to the characteristics of the catalyst used and the reaction process. Generally, the initial temperature is about [X] ° C.
Then, slowly pass in anhydrous hydrogen fluoride gas. The rate of hydrogen fluoride gas is extremely critical. If it is too fast, the reaction will be overheated, and if it is too slow, it will take too long. When entering, it is necessary to continuously stir to make the gas and liquid fully contact and accelerate the reaction.
At the same time, put in an appropriate amount of catalyst. Commonly used catalysts such as antimony pentachloride, aluminum trichloride and other halides, the dosage is about [X]% according to the accurate ratio of p-chlorotoluene mass. The catalyst can significantly reduce the activation energy of the reaction and speed up the reaction rate.
During the reaction process, closely monitor the reaction temperature and pressure. As the reaction proceeds, the temperature will fluctuate, and an external temperature control device needs to be used to maintain stability. The pressure should also be controlled within a specific range to prevent equipment safety hazards.
When the content of p-chlorotrifluorotoluene in the reaction system reaches the expected level, stop introducing hydrogen fluoride gas. Then, move the reaction product to the separation device. After distillation, according to the difference in the boiling point of each component, the crude product of p-chlorotrifluorotoluene is initially separated. The crude product is then rectified and further purified in a high-purity distillation column with a number of plates to obtain high-purity p-chlorotrifluorotoluene products. The entire preparation process requires strict follow of operating procedures to ensure safe production and product quality.
P-Chloro- (A, A, A-) -Benzotrifluoride in storage and transportation
P-chlorine -(α,α,α -) - trifluorotoluene is an organic compound. When storing and transporting, all precautions should not be ignored.
First word storage. This substance should be placed in a cool and ventilated warehouse. If it is sensitive to heat, high temperature will easily cause danger. The temperature of the warehouse should be carefully controlled and not too high to ensure the stability of its chemical properties. And it must be kept away from fire and heat sources, both of which are the cause of danger. Open flames and hot topics may cause them to burn and explode, so precautions must be taken carefully. The substance should be stored separately with oxidizing agents and alkalis, etc., because it is mixed with them, or causes violent chemical reactions, causing unexpected changes. At the same time, the storage place should be equipped with suitable materials to contain the leakage, in case of leakage, it can be quickly disposed of, so as to avoid greater harm.
As for transportation, there are also many points. The transportation vehicle should ensure that the vehicle is in good condition and has complete safety facilities, such as fire prevention and explosion protection devices. During transportation, it is necessary to protect against sun exposure and rain, because the substance is exposed to direct sunlight and rain, or its properties change. The escort personnel must also be familiar with its characteristics and emergency response methods. In case of emergencies, they can respond in time. And transportation can not be mixed with contraband mixed transport, strictly abide by the transport norms, in order to ensure the safety of the transport process. In this way, in the storage and transportation of P-chloro -(α,α,α -) - trifluorotoluene, it is necessary to be careful and thorough, to avoid disasters.