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What are the main uses of P-Aminobenzotrifluoride?
P-aminotrifluorotoluene has a wide range of main uses. In the field of medicine, this is the key raw material for the preparation of many specific drugs. Because organic compounds containing trifluoromethyl groups usually have unique physiological activities, P-aminotrifluorotoluene can be introduced into the molecular structure of the drug by chemical synthesis, which improves the lipid solubility and bioavailability of the drug, and then enhances the efficacy. For example, some innovative drugs for the treatment of cardiovascular diseases and nervous system diseases often rely on P-aminotrifluorotoluene as the starting material in the synthesis process.
In the field of pesticides, P-aminotrifluorotoluene also plays a crucial role. Based on it, high-efficiency, low-toxicity and environmentally friendly pesticide varieties can be created. Due to the characteristics of trifluoromethyl, it can endow pesticides with good stability and biological activity, which can effectively resist the erosion of pests and pathogens, ensure the robust growth of crops, and improve the yield and quality of agricultural products.
Furthermore, in the dye industry, P-aminotrifluorotoluene is also an important intermediate. After a series of chemical reactions, it can synthesize dyes with bright color and excellent fastness, which are widely used in textile, leather and other industries to meet people's needs for various color products.
In addition, in the field of organic synthesis, P-aminotrifluorotoluene can be used as a basic building block for building complex organic molecules. With the reactivity of amino groups and trifluoromethyl groups, chemists can skillfully design and construct organic compounds with specific structures and functions, providing novel compounds for materials science, catalysis, and other fields, and promoting technological innovation and development in related fields.
What are the physical properties of P-Aminobenzotrifluoride?
P-Aminotrifluorotoluene, its physical properties are as follows:
This substance is mostly a colorless to light yellow liquid at room temperature, and it is clear and translucent. Its odor is specific, irritating to a certain extent, and pungent to the smell.
In terms of melting point, it is about -10 ° C, and it will condense into a solid state in a lower temperature environment. The boiling point is in the range of 200 ° C to 205 ° C. It needs to reach this temperature range to transform it from liquid to gaseous.
Its density is larger than that of water, about 1.37 g/cm ³. If mixed with water, it will sink underwater. And it is insoluble with water, but it is easily soluble in common organic solvents such as ethanol, ether, acetone, etc., and can be well dispersed and dissolved in their solvents.
Due to its molecular structure characteristics, this substance has a certain volatility and will slowly evaporate in the air. In addition, it also has a certain refractive index. When light passes through, it will be refracted at a specific angle. This refractive index is relatively stable under specific conditions and can be used as one of the identification characteristics.
What is the chemistry of P-Aminobenzotrifluoride?
P - Aminobenzotrifluoride, the chemical substance is also. Its properties are very specific. In terms of physical properties, under normal conditions, it is mostly white to light-colored crystals, with a certain degree of melting, at 35-38 ℃, so that it has a phase in a specific temperature environment. And it has a certain degree of resistance, and it can be slowly dispersed in the air.
> and trifluoromethyl (-CF), because the molecule contains amino groups (-NH2O) and trifluoromethyl (-CF), so it has a specific reaction activity. The amino group has For example, when encountering an acid such as a sulfuric acid, a sulfuric acid can be formed, which is due to the fact that the sulfuric acid on the nitrogen atom in the amino group can accept sulfuric acid.
Furthermore, the presence of trifluoromethyl groups makes the molecular sulfuric cloud density change. Because of its strong absorber effect, the sulfuric cloud density on the benzene is reduced, and the sulfuric cloud density on the sulfuric acid is affected. Compared with benzene, P-Aminobenzotrifluoride undergoes sulfuric substitution and anti-sulfuric acid, and the anti-sulfuric activity is reduced, and the substituent group is mostly located at the low position of the sulfuric acid (because the amino group is supplied with sulfuric acid, the density of the sulfuric cloud is relatively high).
In addition, P-Aminobenzotrifluoride can be used to form amide compounds, such as acetylation, and amino groups can be used to form amide compounds. This reaction is often used to build compounds containing amides in the field of synthesis. It is used in the synthesis of compounds, materials, etc., to give compounds specific properties. The variety of its chemical properties makes it important in the synthesis of chemical compounds.
What is P-Aminobenzotrifluoride production method?
The preparation method of P-Aminobenzotrifluoride, although the ancient chemical technology is different from that of today, the principle may be found.
In the past, one of the methods for preparing such compounds was to use compounds containing corresponding functional groups as starting materials. First take a suitable aromatic compound with a transformable group on its benzene ring. If p-nitrotrifluorotoluene is used as the starting material, this substance can be obtained by many chemical routes.
Then, p-nitrotrifluorotoluene needs to undergo a reduction reaction to convert the nitro group into an amino group. This reduction reaction is very critical and is often performed with a suitable reducing agent. In ancient times, a combination of metals and acids, such as iron and hydrochloric acid, was used. In this system, the reaction between iron and hydrochloric acid produces new hydrogen, which is highly reducing and can gradually reduce the nitro group to an amino group to obtain P-aminotoluene. The approximate reaction process is that iron reacts with hydrochloric acid to form hydrogen and ferrous ions, hydrogen reacts with the nitro group of p-nitrotrifluorotoluene, and goes through several intermediate states. Finally, the nitrogen atom of the nitro group is reduced from a high valence state to a low-priced state of the amino group.
There is also a method of catalytic hydrogenation. Appropriate catalysts, such as noble metal supported catalysts, are selected, and hydrogen is introduced at suitable temperature and pressure conditions. The nitro group of p-nitrotrifluorotoluene reacts with hydrogen on the surface of the catalyst, and the nitro group is reduced to an amino group to obtain the target product P-aminotoluene. This catalytic hydrogenation method is cleaner and more efficient than the method of metal and acid, and the product is easy to separate and purify.
The method of preparing P-aminotrifluorotoluene depends on the selection of starting materials and the regulation of subsequent reaction conditions, but all of them are chemically converted into the target amino group and trifluoromethyl group coexisting at the opposite check point of the benzene ring.
What are the precautions in storage and transportation of P-Aminobenzotrifluoride?
P-Aminotrifluorotoluene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
When storing, the first environment. It should be placed in a cool and ventilated place, away from fires and heat sources. Because of its flammability, it is easy to cause fire when heated or exposed to open flames. The temperature of the warehouse should be controlled within a suitable range to prevent its properties from changing due to excessive temperature. In addition, it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Because of its active chemical properties, it can be mixed with other substances or react chemically, causing danger. And the storage place needs to be equipped with suitable materials to contain the leakage, in case of leakage, which can be dealt with in time to prevent its spread from causing greater harm.
When transporting, the vehicle must ensure that it is in good condition and has corresponding safety facilities. Transportation personnel need to be professionally trained to be familiar with its dangerous characteristics and emergency treatment methods. During transportation, it is necessary to prevent exposure to the sun, rain and high temperature. If it is road transportation, drive according to the specified route, and do not stop in densely populated areas and residential areas. When loading and unloading, the operation needs to be light and light, and it is strictly forbidden to drop, touch and collide to prevent leakage due to damaged packaging.
In conclusion, the storage and transportation of P-aminotrifluorotoluene requires careful treatment in terms of the environment, item isolation, safety facilities, and personnel operation to ensure the safety of the process.