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What are the main uses of Meta Fluoro Benzotrifluoride?
Meta-Fluoro-Benzotrifluoride, which is m-fluorotrifluorotoluene, is widely used.
In the field of pharmaceutical synthesis, it is an important organic synthesis intermediate. The preparation of many specific drugs requires this as the starting material or key intermediate. For example, some innovative drugs with unique pharmacological activities for specific diseases, in their synthesis path, m-fluorotrifluorotoluene can participate in a variety of key chemical reactions due to its special chemical structure. After a series of transformations, a drug molecular structure with precise pharmacological effects can be constructed to help humans fight diseases.
In the creation of pesticides, m-fluorotrifluorotoluene also plays a key role. The development of new and efficient pesticides often relies on its special structure. The pesticides it participates in the synthesis have high selectivity and high efficiency against pests, are environmentally friendly, and have low residues. They can not only effectively protect crops from pest infestation, improve yield and quality, but also meet the current needs of green agriculture development and reduce the adverse impact on the ecological environment.
In the field of materials science, its role cannot be underestimated. In the preparation of high-performance organic materials, m-fluorotrifluorotoluene can introduce special functional groups, giving the material unique properties. For example, for the synthesis of special engineering plastics, it can enhance the heat resistance, chemical corrosion resistance and mechanical properties of plastics, and is widely used in aerospace, electronics and other fields that require strict material properties. In the synthesis of optical materials, it can optimize the optical properties of materials, such as improving transparency, refractive index, etc., to meet the high-end needs of optical instrument manufacturing.
What are the physical properties of Meta Fluoro Benzotrifluoride?
Meta-Fluoro-Benzotrifluoride, which is m-fluorotrifluorotoluene, is an organic compound. It has the following physical properties:
In terms of view, m-fluorotrifluorotoluene is a colorless and transparent liquid, clear and free of variegated colors. Smell, with a special smell, this smell is specific and highly recognizable.
Regarding the melting point, its melting point is about -62 ° C, and its boiling point is about 102-103 ° C. Such melting boiling point characteristics make it a liquid at room temperature. The lid is in a liquid state because its melting point is very low, much lower than normal temperature, and the boiling point is not very high, and the normal temperature conditions do not reach its boiling point.
When it comes to density, it is about 1.328g/cm ³, which is relatively dense compared to the density of water of 1g/cm ³. If it is mixed with water, it will sink to the bottom of the water.
In terms of solubility, m-fluorotrifluorotoluene is difficult to dissolve in water. This is because water is a polar molecule, and m-fluorotrifluorotoluene is a non-polar or weakly polar organic compound. According to the principle of "similar miscibility", the polarity is different, so it is difficult to dissolve in water. However, it is soluble in many organic solvents, such as common organic solvents such as ethanol and ether, which can be miscible with it.
In terms of volatility, m-fluorotrifluorotoluene has a certain volatility. Because its boiling point is not very high, at room temperature, the thermal movement of molecules prompts some molecules to escape from the liquid surface and dissipate into the air. This volatility causes it to be sealed during storage and use to prevent volatilization loss, and because of its certain toxicity and irritation, volatilization also poses safety and health risks.
In addition, the vapor pressure of m-fluorotrifluorotoluene has a corresponding value at a specific temperature. The vapor pressure reflects the equilibrium relationship between the liquid and its vapor, and its vapor pressure increases with the increase of temperature. This characteristic is related to the melting boiling point and volatility. When the temperature increases, the vapor pressure increases, and it is more volatile.
Meta Fluoro Benzotrifluoride
Meta-Fluoro-Benzotrifluoride, that is, m-fluorotoluene, is one of the organic compounds. Its physical properties are unique. It is usually a colorless to light yellow liquid at room temperature, with a special odor and insoluble with water, but it can be miscible with common organic solvents such as ethanol and ether.
When it comes to chemical properties, its benzene ring is affected by the presence of fluorine atoms and trifluoromethyl. Trifluoromethyl has strong electron absorption. Although fluorine atoms are electron-donating groups, the induction effect is electron-withdrawing. The combined action of the two reduces the electron cloud density of the benzene ring. As a result, the electrophilic substitution reaction activity of the benzene ring decreases, and the reaction conditions are more severe than that of benzene.
In electrophilic substitution reactions, new substituents often enter the meta-site due to the positioning effect of fluorine atoms and trifluoromethyl groups. For example, in halogenation reactions, under the action of suitable catalysts such as ferric chloride, they can react with halogens to form meta-halogenated products. During nitrification reactions, stronger nitrification conditions are required, such as concentrated nitric acid and concentrated sulfuric acid mixed with acid, and the products are also mainly meta-nitro substitutes.
Its fluorine-containing structure endows the compound with certain chemical stability and thermal stability, and is widely used in the field of organic synthesis. It can be used as an intermediate for the synthesis of complex organic compounds in the fields of medicine, pesticides and materials. For example, in the creation of pesticides, its structural characteristics can be used to synthesize pesticide molecules with specific biological activities, in order to enhance the efficacy and environmental stability of pesticides.
What is the production method of Meta Fluoro Benzotrifluoride?
The method of preparing m-fluorotoluene is very complicated and requires intensive chemical research. Common ones are about the following numbers.
First, m-fluorotoluene is used as the starting material, halogen atoms are introduced through the side chain halogenation method, and then fluorinated. During this process, when the side chain is halogenated, the reaction conditions need to be controlled to ensure that the halogenating agent reacts moderately with m-fluorotoluene to obtain a side chain monohalide. Next, under the action of appropriate solvents and catalysts, the halogen is reacted with the fluorinating agent, and the halogen is replaced with a fluorine atom, and m-fluorotoluene is finally obtained.
Second, starting from m-chlorotoluene, metal fluoride is used, and nucleophilic substitution is achieved. Select a suitable metal fluoride, such as potassium fluoride, in a specific organic solvent, heat up and stir to promote its reaction with m-chlorotrifluorotoluene. In this process, the choice of solvent is crucial, it needs to be able to dissolve the reactants and facilitate the reaction. At the same time, the temperature and reaction time also need to be precisely controlled to ensure that the chlorine atoms are efficiently replaced by fluorine atoms, and the yield and purity of the product are improved.
Third, using m-amino trifluorotoluene as raw material, it is prepared by diazotization and fluorination reaction. First, m-amino trifluorotoluene and sodium nitrite undergo diazotization in an acidic medium to form diazonium salts. Subsequently, the diazonium salt is reacted with fluoroboronic acid or other fluorine sources, and the diazonium group is replaced by fluorine atoms through thermal decomposition or other suitable conditions to achieve m-fluorotrifluorotoluene. This path operation needs to pay attention to the safety of the diazotization reaction, because many diazonium salts are unstable.
All production methods have advantages and disadvantages. During the actual preparation, the actual preparation should be carefully selected according to many factors such as the availability of raw materials, cost considerations, equipment conditions and product quality requirements. And in the chemical preparation process, safety comes first, and each reaction step must follow strict operating procedures to ensure the smooth production and the safety of personnel.
What is the price range of Meta Fluoro Benzotrifluoride in the market?
I don't know the exact price of "Meta+Fluoro+Benzotrifluoride" in the market, but I can slightly deduce it according to the past market conditions and the price status of related materials. This compound, called fluorobenzo trifluoride, is a commonly used raw material in organic synthesis, and is widely used in medicine, pesticides, materials and other fields.
Its price often varies due to changes in purity, supply and demand, production process, and market conditions. If the purity is extremely high, it can reach the excellent purity required for experimental research, and the price is not cheap. Because the preparation of this high-purity compound requires fine processing and multiple purification sequences, the cost is high. In the past, the price of such high-purity compounds could reach tens or even hundreds of yuan per gram.
If it is industrial grade and used for large-scale production, although the purity is slightly inferior, the price may be calculated in tons due to the large amount used. In the past, the price per ton of industrial grade may be between tens of thousands and hundreds of thousands of yuan. However, if the market supply is abundant and the cost is reduced due to the innovation of production technology, the price may also drop. In case of a large increase in demand and a shortage of supply, the price may rise.
In addition, its price is also affected by the cost of raw materials and transportation costs. The fluctuation of the price of fluoride raw materials, the distance of transportation and the difference in transportation methods can all make the final selling price different. Therefore, for the accurate price, you should consult the chemical raw material supplier and refer to the real-time market conditions.