M-Toluenesulfonyl Fluoride

Duxiu Chemical

Specifications

HS Code	655330
Chemical Formula	C7H7FO2S
Molar Mass	174.19 g/mol
Appearance	Colorless to light yellow liquid
Boiling Point	265 - 267 °C
Melting Point	14 - 16 °C
Density	1.294 g/cm³
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in many organic solvents like dichloromethane, chloroform
Flash Point	110 °C
Pungent Odor	Yes
Cas Number	4089-98-9
Main Use	Reagent in organic synthesis, especially for peptide synthesis

As an accredited M-Toluenesulfonyl Fluoride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of M - Toluenesulfonyl Fluoride in a sealed, chemical - resistant container.
Storage	M - Toluenesulfonyl Fluoride should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent moisture and air exposure. Store it separately from incompatible substances like strong bases and oxidizing agents to avoid potential reactions. Follow proper safety protocols during storage.
Shipping	M - Toluenesulfonyl Fluoride is shipped with strict safety protocols. Packed in suitable, leak - proof containers, it's transported by approved carriers following hazardous chemical shipping regulations to ensure safe delivery.

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General Information

Historical Development

M Toluenesulfonyl Fluoride, its origin is not overnight. At the beginning, the academic community studied in related fields and gradually came to know this compound. In the early years, the sages only knew a little about its characteristics, but did not know the whole picture.
After that, many scholars worked hard to explore it with scientific methods. After countless experiments, its structure was analyzed and its reaction was studied. Over the years, the understanding of it has deepened. Knowing its unique use in organic synthesis and other fields.
With the passage of time, the technology has advanced, and the preparation method has become more and more exquisite. From the crude initial to the exquisite today, it all depends on the unremitting efforts of scholars of all dynasties. The development of this compound has witnessed the progress of the academic community, from ignorance to clarity, and has contributed to the grand cause of science, with a brighter future.

Product Overview

M Toluenesulfonyl Fluoride is also a chemical substance. Its unique properties are used in the field of chemistry. This material has unique properties, and can be used for general chemical reaction, or as a catalyst, or as a synthetic material.
Its external appearance is often of a specific type, or a crystalline type, and the color is also specific. In the laboratory, researchers often use it with caution, because of its chemical activity, the operation needs to be in accordance with the standard, in order to prevent accidents.
And this product has a lot of advantages in the field of chemical synthesis, etc. It also plays an important role in the field of chemical materials research.

Physical & Chemical Properties

M Toluenesulfonyl Fluoride is an important reagent for organic synthesis. Its physical properties are colorless to light yellow liquid at room temperature, with a special odor, higher density than water, and can be miscible with some organic solvents. It has active chemical properties and is a strong electrophilic reagent. It is often used as a sulfonylating reagent in organic reactions. It can quickly react with compounds containing hydroxyl groups, amino groups and other nucleophilic groups to form corresponding sulfonamides or sulfonates. Due to its high reactivity and good selectivity, it is widely used in pharmaceutical chemistry, materials science and other fields to help researchers prepare many compounds with special properties. It is an indispensable material for chemical research.

Technical Specifications & Labeling

Today there is M Toluenesulfonyl Fluoride, which is very important in the field of chemical industry. Its technical specifications and identification (product parameters) are the key. Regarding its technical specifications, it is necessary to clarify its purity geometry and impurity content, which is related to its quality. And its physical properties, such as color and morphology, also need to be detailed. On the label, the product name should be exact and not ambiguous, and its chemical structure must be expressed accurately to prevent misuse. As for the product parameters, molecular weight, density and other data, it should be clear, which is the basis for ensuring that it can be used properly in various application scenarios, so that this product can be used in the chemical industry, effective, and safe from operation.

Preparation Method

Now I want to describe the preparation method of M Toluenesulfonyl Fluoride, which is related to the raw materials and production process, reaction steps and catalytic mechanism.
Its raw materials need to be carefully selected to ensure the quality is pure. The production process, like the workmanship of the ancient method, should be gradual. The reaction step is to mix the materials at the beginning, and the temperature needs to be properly controlled, just like the appropriate temperature. The reaction, whether slow or urgent, depends on the conditions.
The catalytic mechanism is also the key. Appropriate catalysts are required to help the reaction go smoothly. It is like a boat traveling smoothly, fast and stable. In this way, pure M Toluenesulfonyl Fluoride can be obtained. When preparing, all aspects should not be ignored, from raw materials to finished products, step by step with caution, in order to achieve the purpose of preparation and obtain satisfactory products.

Chemical Reactions & Modifications

To taste the wonders of chemical industry, it is related to the change of substances. M Toluenesulfonyl Fluoride, its transformation and modification methods can be quite studied.
M Toluenesulfonyl Fluoride has specific reactivity. In the field of organic synthesis, it is often used as a sulfonylating reagent and can interact with many nucleophilic reagents. Looking at its reaction, it meets with alcohols to form sulfonates. During this process, the fluorine atom leaves, and the hydroxyl oxygen nucleophilic of the alcohol attacks the sulfonyl carbon to form new bonds and form sulfonate products. The reaction mechanism is clear, and the conditions need to be precisely controlled. Temperature and solvents are affected.
As for modification, modification can make its performance gain. If a specific group is introduced, it may change its solubility and stability. This is not only related to synthesis technology, but also involves insight into the nature of matter. Through exquisite design, it is expected to expand its application, develop its talents in the fields of medicine and materials, and add new brilliance to the chemical industry.

Synonyms & Product Names

M Toluenesulfonyl Fluoride is also a chemical substance. Its name is the same, or toluenesulfonyl fluoride. This substance is used in chemical research and has a wide range of uses.
Toluenesulfonyl fluoride is very special. In the field of synthesis, it is often used as a chemical agent, and it is often used as a multi-reaction agent. With its active properties, it can initiate the chemical transformation of multiple compounds and assist in the synthesis of new compounds.
In the field of work, it also has its own impact. Because of its characteristics, it can be used in the manufacture of specific products and improve the performance of the product. However, when using it, you must be careful and be familiar with the operation method of its properties to avoid danger to life.
Therefore, M Toluenesulfonyl Fluoride, which is toluenesulfonyl fluoride, plays an important role in chemical engineering, and researchers must not know it.

Safety & Operational Standards

For M toluenesulfonyl fluoride, it is also a genus of chemical drugs. Regarding its safety and operating specifications, it should be carefully stated.
This medicine is poisonous to a certain extent, and it can be harmful if touched, smelled or ingested by mistake. Therefore, when handling, it is necessary to wear protective equipment, such as gloves, masks, goggles, etc., to prevent the skin, respiratory tract and eyes from being invaded by it.
Store it in a cool, dry and well-ventilated place to avoid heat, moisture and light. Store it separately with other substances, especially avoid mixing with alkalis, oxidants, etc., to avoid chemical reactions and cause critical conditions.
When using it, weigh it accurately and operate according to the prescribed method. Dissolve it or match it, in the fume hood, so that the foul gas can dissipate quickly. After the reaction is completed, do not discard the residual medicine, and deal with it according to the regulations to prevent the environment.
Also, if you accidentally touch it, quickly flush the skin with a lot of water; if it enters the eyes, turn your eyelids, rinse with water and seek medical attention. If you sniff or take it by mistake, leave the scene quickly, breathe fresh air, and those who take it by mistake need to induce vomiting and seek medical attention immediately.
In short, the safety and operation standards of M toluenesulfonyl fluoride are related to personal safety and environmental tranquility, and the operator must follow them carefully and not slack off in the slightest.

Application Area

M toluenesulfonyl fluoride is a good chemical product. Its application field is quite extensive. In the field of biochemical research, it is often used as a protease inhibitor. Cover protease, the key to protein metabolism in organisms, if it is lost control, it will be physiological chaos. M toluenesulfonyl fluoride can be delicately combined with protease activity check point, so that its activity is suppressed, so as to maintain the orderly biochemical process.
In the pharmaceutical industry, it also shows its ability. Pharmaceutical aids act precisely on the target, improve the efficacy of the drug, and reduce its side effects. Because it can effectively inhibit the activity of specific enzymes, so that the efficacy of the drug is better. And in material science, or can modify the surface of the material to increase its stability and functionality. Overall, M-toluenesulfonyl fluoride is widely used in various fields and has made significant contributions to the development of scientific research and industry.

Research & Development

In recent years, I have studied M Toluenesulfonyl Fluoride, which has different properties and can be used in all transformation environments. At the beginning, I studied the method of its preparation, and obtained exquisite recipes through various techniques, which increased the yield.
Then explore its use, in the field of biochemistry, it can inhibit the activity of enzymes and preserve protein properties. It is a sharp tool for analyzing the structure and function of proteins. The road of medicine has also emerged, or it may be the basis for new drugs for treating diseases.
Looking at its development, the prospect is clear. Scientists are working hard day and night to expand its use and make it shine in more fields. With time, we will be able to add luster to human well-being, blaze new trails in the path of chemical research, and be praised by future generations.

Toxicity Research

Recently studied poisons, there is a name M Toluenesulfonyl Fluoride. Its nature is toxic, and it is very harmful.
Yu et al. studied in detail to observe the signs of its toxic hair and test the path of its entry into the body. Looking at the experiments, this agent can be sick when it touches the skin or enters the mouth and nose. Its toxic hair can also cause swelling and pain in the skin, or cause internal organs to violate.
The reason why it is poisonous is that it can disrupt the normal order of biochemistry in the body and disturb all kinds of metabolism. The transportation of cells and the functions of enzymes are all messed up. Although today's research has not yet fully understood its toxicology, its harm is already obvious. Our generation should be careful and study protective methods to ensure that this poison will not cause harm to the world.

Future Prospects

In the future, M Toluenesulfonyl Fluoride is a product whose development has never been limited. Today, it has been studied, but there are still many things to be explored.
Looking forward to it, or it can be used to develop its wonders in the field of technology, help the sick to suffer, and make the health of the world. Or it can be used to make new materials, and the material can be used to make it an unprecedented material.
In addition, there may be new methods for the way of transformation and synthesis. It can be used to make progress, improve the degree of refinement, and make the synthesis more delicate. And the shadow of its environment, if it is well researched, may be able to benefit and avoid harm, and the environment of symbiosis. In addition, M Toluenesulfonyl Fluoride is not yet available, and it is possible to develop it in depth.

Where to Buy M-Toluenesulfonyl Fluoride in China?

As a trusted M-Toluenesulfonyl Fluoride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading M-Toluenesulfonyl Fluoride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the chemical structure of M-Toluenesulfonyl Fluoride?

M - Toluenesulfonyl Fluoride is also a chemical substance, and its chemical properties are special. The Chinese name of this compound is toluenesulfonyl fluoride. It is based on benzene and bone. Above benzene, in the position (1,3-bit), one methyl ($- CH_3 $), this methyl alkyl group has a certain effect. Another substituent is sulfonyl fluoryl ($- SO_2F $). In the sulfonyl fluoryl group, the sulfur atom and the oxygen atom are intertwined with each other, forming a sulfur and oxygen atom, which makes the sulfur atom have a certain positive property. And the sulfur atom is also the phase of the fluorine atom. The fluorine atom, because of its strong strength, makes the mono-sulfonyl fluoryl group appear to be the absorber characteristic.
In addition, M-Toluenesulfonyl Fluoride is formed by the benzene group, which is substituted by the methyl sulfonyl fluoride group at the position, so that it has a unique chemical property. It has a specific role in the reaction and phase domains.

What are the main uses of M-Toluenesulfonyl Fluoride?

M-toluenesulfonyl fluoride has a wide range of uses. In the field of organic synthesis, it is often used as a sulfonylation reagent. It can react with many compounds containing active hydrogen, such as alcohols and amines, and introduce sulfonyl groups to change the properties and structures of the compounds. The resulting products are of great significance in the pharmaceutical, pesticide and other industries.
In pharmaceutical research and development, it can participate in the preparation of a variety of drug intermediates. Structural modification of lead compounds through sulfonylation reactions may enhance the activity of drugs and improve their pharmacokinetic properties, such as increasing the stability of drugs and adjusting their solubility, laying the foundation for the creation of new and efficient drugs.
In the field of materials science, m-toluenesulfonyl fluoride is also useful. Some of the sulfonyl-containing polymer materials it participates in the synthesis exhibit unique physical and chemical properties, such as good thermal stability, mechanical properties and chemical stability. It can be applied to the preparation of high-performance engineering plastics and special coating materials to improve the comprehensive properties of materials to meet the needs of different fields for special properties of materials.
In addition, in the field of surface treatment, it can modify the surface of materials. After appropriate treatment, the surface of the material is endowed with special properties such as anti-adhesion and anti-corrosion, which broadens the application range of the material and improves its performance in specific environments. In short, m-toluenesulfonyl fluoride plays an important role in many fields and has made great contributions to the development of related industries.

What are the precautions for M-Toluenesulfonyl Fluoride during use?

M-Toluenesulfonyl Fluoride (M-Toluenesulfonyl Fluoride) is an important reagent in organic synthesis. When using it, many things need to be paid attention to.
First, this reagent is toxic and corrosive. Its toxicity can harm the human body through inhalation, ingestion or skin contact. If inadvertently inhaled, or cause respiratory irritation, or even cause more serious health problems; if it comes into contact with the skin, it can corrode the skin and cause burns. Therefore, when using, be sure to take protective measures, wear protective clothing, protective gloves and protective glasses, and operate in a well-ventilated environment, such as a fume hood, to avoid the accumulation of toxic gases.
Second, M-toluenesulfonyl fluoride is chemically active. It is easy to hydrolyze in contact with water, resulting in the failure of the reagent, and the hydrolyzed products may be more corrosive. Therefore, when storing, it is necessary to ensure that it is in a dry environment, sealed in time after taking it, to prevent contact with water vapor in the air. In organic synthesis reactions, it is necessary to fully consider its reactivity and strictly control the reaction conditions, such as temperature, reaction time and ratio of reactants. If the temperature is too high, the reaction may be too violent, difficult to control, and easy to produce side reactions; improper control of the reaction time will also affect the yield and purity of the product.
Third, M-toluenesulfonyl fluoride should pay attention to its compatibility when mixed with other reagents. Some reagents are mixed with it, or cause violent reactions or even explosions. Therefore, before use, you should understand the reaction characteristics of it with other reactants in detail, and follow the correct addition order and operation method. During the mixing process, you need to closely observe the reaction phenomenon, and take corresponding measures immediately if there is an abnormality.
In short, when using M-toluenesulfonyl fluoride, you must have a deep understanding of its properties, strictly follow the operating procedures, and operate with caution to ensure the safety of the experiment and the smooth progress of the reaction.

What is the synthesis method of M-Toluenesulfonyl Fluoride?

M-toluenesulfonyl fluoride is prepared by co-heating M-toluenesulfonic acid with thionyl chloride to obtain M-toluenesulfonyl chloride, which should be formulated as: M-CH
The resulting M-toluenesulfonyl chloride is then reacted with anhydrous potassium fluoride in a suitable organic solvent. Commonly used organic solvents such as N, N-dimethylformamide (DMF), acetonitrile, etc. During this step of reaction, temperature control is required, generally between 50 and 100 ° C. The corresponding formula is: M-CH < unk > C < unk > H < unk > SO < unk > Cl + KF → M < unk > CH < unk > C < unk > H < unk > SO < unk > F + KCl. After the reaction is completed, the pure M-toluenesulfonyl fluoride is obtained by separation and purification. During separation, the generated potassium chloride precipitation can be filtered off first, and then the filtrate is distilled under reduced pressure to remove the organic solvent to obtain the crude product. After purification by recrystallization or column chromatography, the refined product is obtained.
Another method is to start with M-toluene thiophenol, first oxidize to M-toluenesulfonic acid, and then convert to M-toluenesulfonyl fluoride according to the above method. When oxidizing, hydrogen peroxide, potassium permanganate and other oxidants can be used. If hydrogen peroxide is used as the oxidant, M-toluenesulfonic acid can be obtained in the presence of a suitable catalyst (such as sodium tungstate), followed by chlorination and fluoridation steps to finally obtain M-toluenesulfonyl fluoride.

What are the Physical and Chemical Properties of M-Toluenesulfonyl Fluoride

M-Toluenesulfonyl Fluoride (M-Toluenesulfonyl Fluoride), which is a colorless to pale yellow liquid. Its boiling point is quite high, about 226-227 ° C. At this temperature, the intermolecular forces need enough energy to overcome, causing it to change from liquid to gaseous. The melting point is relatively low, about -32 ° C. At this temperature, the molecular motion is limited, and the arrangement tends to be orderly, so it becomes a solid state.
The density of m-toluenesulfonyl fluoride is about 1.246g/cm ³, which is heavier than water, so if it is mixed with water, it will sink to the bottom of the water. Its solubility is quite special, soluble in organic solvents such as ethyl ether and dichloromethane, because these organic solvents and m-toluenesulfonyl fluoride molecules can form similar intermolecular forces, following the principle of "similar phase dissolution"; however, its solubility in water is very small, because of its molecular structure, the phenyl ring and sulfonyl fluoride groups have strong hydrophobicity, and it is difficult to form effective interactions with water molecules.
From the perspective of chemical properties, the sulfonyl fluoride group of m-toluenesulfonyl fluoride is extremely active and easily reacts with compounds containing active hydrogen, such as alcohols and amines. When reacting with alcohols, sulfonates can be formed. During this process, fluorine atoms are replaced by oxygen atoms of alcohol hydroxyl groups, which is a typical nucleophilic substitution reaction. When reacted with amines, sulfonamides are formed. This reaction is widely used in the field of organic synthesis and can be used to construct the structure of nitrogen-containing compounds. Due to its active chemical properties, special attention must be paid when storing and using m-toluenesulfonyl fluoride. It is often necessary to keep it sealed in a cool and dry place to avoid contact with water and substances containing active hydrogen to prevent unnecessary chemical reactions.