As a leading 4-(Tert-Butoxy)Benzotrifluoride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 4- (Tert-Butoxy) Benzotrifluoride?
4- (tert-butoxy) trifluorotoluene has a wide range of uses. In the field of organic synthesis, it is a key intermediate. In terms of the preparation of specific drugs, its structure can be cleverly modified through chemical reactions, incorporated into drug molecules, giving drugs unique pharmacological activities, which are of great benefit to the treatment of specific diseases.
In the field of materials science, 4- (tert-butoxy) trifluorotoluene also has important functions. After special processing, it can participate in the material synthesis process and improve material properties, such as enhancing material stability and enhancing chemical resistance, which contribute to the creation of high-performance new materials.
In the preparation of fine chemical products, it can be used as a raw material or additive to improve product quality and performance. If used in the production of special coatings, it can endow the coatings with excellent weather resistance and wear resistance, making them suitable for a variety of harsh environments.
In summary, 4 - (tert-butoxy) trifluorotoluene is an indispensable substance in many fields such as organic synthesis, materials science, and fine chemicals, promoting technological progress and product innovation in various fields.
What are the physical properties of 4- (Tert-Butoxy) Benzotrifluoride?
4- (tert-butoxy) trifluorotoluene is also an organic compound. Its physical properties are quite impressive.
Looking at its properties, under normal temperature and pressure, it often appears as a colorless to light yellow transparent liquid, which is convenient for it to participate in reactions in many chemical reaction systems. And because it is a liquid, it has good fluidity, which can make the contact between the reactants more sufficient and accelerate the reaction process.
As for the boiling point, it is within a certain numerical range. This boiling point characteristic determines the conditions required for separation, purification and other operations. If you want to separate this substance from the mixture, you need to apply the method of distillation according to its boiling point, control the appropriate temperature, so that 4 - (tert-butoxy) trifluorotoluene is gasified and then condensed to collect, so as to achieve the purpose of purification.
Melting point is also one of its important physical properties. Under specific low temperature conditions, this substance will change from liquid to solid. Knowing the melting point is of great significance during storage and transportation. It can be adjusted according to the ambient temperature to ensure that it maintains the required physical state and avoids changing its state due to improper temperature and affecting the quality.
Its density has a specific value compared to water. This density characteristic is very important in the operation of liquid-liquid separation. If the density of the liquid mixed with it is significantly different from it, the two can be separated by liquid separation method, and the delamination characteristics under the action of gravity can be used to achieve effective separation.
In terms of solubility, 4- (tert-butoxy) trifluorotoluene is soluble in some organic solvents, such as common aromatic hydrocarbons, halogenated hydrocarbons and other solvents. This solubility facilitates its use as a solvent or reactant in organic synthesis, allowing the reaction to proceed in a homogeneous system, which helps to improve the reaction rate and product purity.
In addition, its volatility is also reflected to a certain extent. Although it is not highly volatile, some molecules will still escape into the air under appropriate temperature and ventilation conditions. When handling this substance, it is necessary to pay attention to this characteristic and take ventilation protection measures to ensure the safety of operators and the cleanliness of the environment.
What are the chemical properties of 4- (Tert-Butoxy) Benzotrifluoride?
4 - (tert-butoxy) trifluorotoluene is also an organic compound. Its properties are both physical and chemical.
In terms of its physical properties, under room temperature and pressure, it is a colorless and transparent liquid with a light taste and no odor. Its boiling point is moderate, and it gasifies at a certain temperature, which can be used for separation and purification. Its density is lighter than that of water, and it is insoluble in water, but it is miscible with common organic solvents such as ethanol, ether, and dichloromethane. Due to the similar principle of compatibility, its molecular structure is similar to that of organic solvents.
As for chemical properties, because it contains trifluoromethyl, it has strong electronegativity, which makes the molecule have a certain polarity, which affects its reactivity. The tert-butoxy group is the power supply group. Although the steric barrier is large, it is useful in specific reactions. It can participate in nucleophilic substitution reactions. Because the electron cloud density of the benzene ring is affected by the substituent group, the nucleophilic reagent can attack the specific position of the benzene ring. Under appropriate conditions, the ether bond cleavage reaction occurs, which may cause the tert-butoxy group to leave due to the acidic or basic environment, and then form new compounds. And in oxidation and reduction reactions, depending on the reaction conditions, there are different transformations, which may increase the number of organic synthesis paths. In organic synthesis in the fields of medicine, pesticides, materials, etc., it is often used as a key intermediate to form products with special properties.
What are the synthesis methods of 4- (Tert-Butoxy) Benzotrifluoride?
To prepare 4 - (tert-butoxy) trifluorotoluene, the following numbers are often followed.
First, 4-hydroxytrifluorotoluene is reacted with tert-butanol under the action of an appropriate catalyst. 4-hydroxytrifluorotoluene has an active hydroxyl group, and the hydroxyl group of tert-butanol can be substituted with it. This reaction requires the selection of a suitable catalyst, such as concentrated sulfuric acid or a specific Lewis acid. Concentrated sulfuric acid can promote protonation, making the hydroxyl group of tert-butanol easy to leave, and the phenoxy negative ion of 4-hydroxytrifluorotoluene attacks the nucleophilic, and then becomes the target product. However, concentrated sulfuric acid is highly corrosive, and the operation needs to be cautious. The reaction conditions are harsh, and the temperature and time need to be controlled accurately. Otherwise, side reactions will occur and
Second, 4-halogenated trifluorotoluene reacts with potassium tert-butoxide. The halogen atom in 4-halogenated trifluorotoluene has high activity, and potassium tert-butoxide has strong alkalinity and nucleophilicity. The oxygen anion of potassium tert-butoxide nucleophilically attacks the alpha-carbon of the halogen, and the halogen ion leaves to form 4- (tert-butoxy) trifluorotoluene. This reaction condition is relatively mild and the yield is high. However, potassium tert-butoxide needs to be prepared and used now, because it is sensitive to water and air and inconvenient to store.
Third, 4-nitrotrifluorotoluene is used as the starting material. It is first reduced to 4-aminotrifluorotoluene, and then diazotized and hydrolyzed to obtain 4-hydroxytrifluorotoluene, and then reacted with tert-butanol according to the first method. This route step is complicated, but the raw material is easy to obtain. When reducing 4-nitrotrifluorotoluene, hydrogen-palladium carbon or iron-hydrochloric acid systems can be selected. The diazotization reaction needs to be low temperature to maintain the stability of the diazonium salt, and the conditions for hydrolysis need to be carefully regulated.
All these production methods have advantages and disadvantages. In actual synthesis, the choice is based on factors such as raw material availability, cost, yield and purity.
What is the price range of 4- (Tert-Butoxy) Benzotrifluoride in the market?
4 - (tert-butoxy) trifluorotoluene, the value of the market is difficult to determine. The change in its price is affected by various factors.
First, the state of supply and demand is the key. If there are many people in the market, but the supply is small, the price will tend to rise; conversely, if the supply exceeds the demand, the price will drop.
Second, the cost of production is also a factor. The price of raw materials, the cost of labor, and the consumption of equipment are all related to the production. If the price of raw materials is high, or the cost of labor and equipment increases, the price will also rise.
Third, the competition in the market has a great impact.
Fourth, the regulations of government decrees cannot be ignored. Changes in taxes and different regulations can make prices different. Taxes increase in weight, and prices may rise as a result; loose regulations may have the effect of reducing costs and promoting prices.
Looking at the past, the price of such chemicals in the market fluctuated every time. However, the price of 4 - (tert-butoxy) trifluorotoluene is now between hundreds and thousands of yuan per kilogram or per kilogram. If you want to know the exact number, you should consult the commercial of chemical materials or observe the real-time reports in the market.