4 Methoxybenzenesulfonyl Fluoride
Fluoride Fluoropolymers Hydrofluoric Acid/Foaming Agent Fluoride Salt Fluorine-Containing

4-Methoxybenzenesulfonyl Fluoride

Duxiu Chemical

Specifications

HS Code

277381

Chemical Formula C7H7FO3S
Molar Mass 190.19 g/mol
Appearance Colorless to light yellow liquid
Boiling Point ~120 - 122 °C at 1.5 mmHg
Density 1.336 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in many organic solvents like dichloromethane
Purity Typically available in high purity grades, e.g., 98%+
Chemical Formula C7H7FO3S
Molar Mass 190.19 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 142 - 143 °C (10 mmHg)
Melting Point 22 - 24 °C
Density 1.31 g/cm³
Solubility Soluble in organic solvents like dichloromethane, chloroform
Flash Point 122 °C
Purity Typically high purity, e.g., 98%+ in commercial products
Vapor Pressure Low vapor pressure at room temperature

As an accredited 4-Methoxybenzenesulfonyl Fluoride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 4 - Methoxybenzenesulfonyl Fluoride packaged in a sealed, chemical - resistant bottle.
Storage 4 - Methoxybenzenesulfonyl Fluoride should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly closed container to prevent moisture and air exposure, which could potentially lead to decomposition. Store it separately from incompatible substances, such as strong oxidizers and bases, to avoid dangerous reactions.
Shipping 4 - Methoxybenzenesulfonyl Fluoride is shipped in accordance with strict chemical regulations. It's typically packed in air - tight, corrosion - resistant containers. Shipments are monitored for temperature and transported by carriers experienced in handling hazardous chemicals.
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4-Methoxybenzenesulfonyl Fluoride
General Information
Historical Development
4-Methoxybenzenesulfonyl Fluoride, or 4-methoxybenzenesulfonyl fluoride, has been developed over the years. At the beginning, the academic community studied in the field of organic chemistry and relentlessly searched for new reagents to help many reactions advance efficiently.
At that time, there were many problems in organic synthesis, and chemists were struggling to find ways to optimize the reaction. 4-methoxybenzenesulfonyl fluoride was first discovered. Due to its unique chemical properties, it can act as a key reagent in specific reactions and help to build chemical bonds accurately.
With in-depth research, chemists have become more aware of its potential in protein research and other fields. It can react with specific groups, providing a powerful tool for analyzing protein structure and function. Since then, the preparation process has been continuously improved, the purity and yield have been increased, and it has gradually emerged in the fields of scientific research and industry, becoming an indispensable chemical material and playing an important role in many cutting-edge research.
Product Overview
4 - Methoxybenzenesulfonyl Fluoride, it is also a chemical compound. Its shape and color are often from dark to light-colored liquid, and its properties are special. It has a high anti-activity, and it is often important in multi-conversion and anti-reaction.
Its use is wide, and it can be used as a sulfonylation agent in the field of synthesis. It is used to introduce sulfonyl groups to help form a variety of chemical compounds. It also plays an important role in research, or the synthesis of chemical substances, which is a new research problem.
The production of this compound requires specific chemical processes, such as degree, proportion of chemical reactants, etc., to obtain it. Therefore, 4 - Methoxybenzenesulfonyl Fluoride is indispensable in chemical research and related work.
Physical & Chemical Properties
4 - Methoxybenzenesulfonyl Fluoride, this substance is also very different in nature. Looking at its physical properties, it is often colorless and transparent. If it is a liquid flow, it is pure and clear. Its boiling point is moderate, and at a specific temperature, it dissolves gas and rises, volatile, but also orderly.
On its chemical quality, it is lively and sensitive. In case of alkali, it should be a functional group, changing its shape. Its sulfonyl fluoro group is the nucleus of the reaction, and its electrophilic power is quite strong, and it can combine with various substances. And the methoxy group also adds characteristics, affecting the cloud of electrons, causing the reaction path to be unique. It is of great use in the combination of organic and medical systems. With its materialized quality, it forms various exquisite structures, which contribute to the progress of science.
Technical Specifications & Labeling
There are 4 - Methoxybenzenesulfonyl Fluoride today, which is related to its technical specifications and identification (product parameters). Its quality needs to be pure, and impurities should not disturb its properties. Looking at its color, it should be [specific color], no variegated colors mixed. Smell its smell, it should have [specific odor characteristics], and do not have peculiar smell. Its melting point should be in the [specific melting point range], which is one of the requirements for determining its purity. And its content should not be lower than [specific content value], which is the basis of quality. On the logo, the product name should be clear, and the parameters should also be listed in detail, so that the viewer can know its nature and use, so that it is a suitable product and can be used in various applications.
Preparation Method
To make 4 - Methoxybenzenesulfonyl Fluoride, the raw materials and production process, reaction steps and catalytic mechanism are very important.
First take an appropriate amount of p-methoxybenzenesulfonic acid, place it in a clean reactor, and slowly heat it at low temperature to make it initially activated. Prepare anhydrous potassium fluoride, slowly add it to the kettle in an appropriate proportion, and introduce an appropriate amount of inert gas to ensure a stable reaction environment.
Heat up to a suitable range to maintain this state, so that the two can fully react. This process requires fine regulation of temperature and time, and must not be rushed. When the reaction is coming to an end, collect the product by condensation.
Following the purification process, by recrystallization and extraction, impurities are removed to obtain pure 4-Methoxybenzenesulfonyl Fluoride. During the whole process, the use of catalytic mechanism can significantly accelerate the reaction rate and improve the yield of products, which is an indispensable link.
Chemical Reactions & Modifications
4 - Methoxybenzenesulfonyl Fluoride, it is also a chemical substance. Its transformation and reverse modification are of great importance to chemical researchers. The reaction of this compound is often involved in the reaction of the chemical compound. Its energy is like a reaction, or the generation of new materials, which is the basis of the modification of the chemical compound.
The reaction of the chemical compound can be different depending on the quality of the product. The degree of resistance, solubility, and catalysis can all affect the speed of its reaction. If a suitable environment is obtained, it can be used to modify its specific reaction and give new properties.
Chemical researchers often explore its reaction, in order to understand the role of its molecules in order to achieve precise control of the reaction. Study the anti-modification of this compound, hope to expand the field of chemical engineering, make it easier to work, and promote the first step of chemical engineering, so as to be used in the world.
Synonyms & Product Names
4 - Methoxybenzenesulfonyl Fluoride, this thing is also, its synonymous name and the name of the commodity are quite important. The name of the synonym can help the public to express the meaning accurately in academic discussions; the name of the commodity is clearly referred to in the market and trade circulation.
View its synonymous name, or have another name for the needs of different contexts. When chemical learners are exploring classics and theoretical studies, the name of the synonym can make communication smooth and avoid ambiguity. And the name of the commodity is determined by the merchant according to the state of the market and the audience, aiming to sell widely and attract attention.
The synonymous names and trade names of such things complement each other, and are of great significance in both chemical research and business, paving the way for the development and exchange of the industry.
Safety & Operational Standards
4-Methoxybenzenesulfonyl fluoride is also a chemical product. Regarding its safety and operating standards, we should be cautious.
This substance has specific properties, and when handling, it is the first priority to be quiet. The surrounding environment must be well ventilated to avoid the risk of explosion. It should be in contact with other things or play a role, so when placed, it must be separated from the responder to ensure safety.
When handling, protective gear is indispensable. It is appropriate to wear protective clothing, wear protective covers on your hands, and wear protective glasses for your eyes, so as to protect against its damage and prevent skin and eyes from being invaded.
When weighing and transferring, the method should be stable and accurate. Do not let it escape from the outside. If it is accidentally spilled, deal with it as soon as possible according to the regulations. First isolate the scene, prohibit unrelated people from approaching, and then remove it by appropriate methods, so that it can be cleaned.
When storing, choose a cool, dry and ventilated place. Seal it in a secret container and mark its name, sex, date, etc., so that you can check it.
Furthermore, the person who handles it must first know its nature and specify the norms. After special training, I am familiar with all kinds of emergency measures. If there is an accident, I can respond to it quickly and reduce the damage to a small extent.
In general, the safety and operating standards of 4-methoxybenzenesulfonyl fluoride are related to the safety of the operator and all things go well. They must not be ignored and must be strictly observed to ensure the safety of all things.
Application Area
4-Methoxybenzenesulfonyl fluoride is also a new chemical substance. Its application field is worth exploring. In the field of biochemical research, it can block the activity of specific enzymes, and assist in the research of the mechanism of enzymes, such as paoding to dissolve cattle, and the action path of enzymes. In the way of pharmaceutical creation, it is expected to become a lead compound, looking for new drugs, like a guiding light, guiding the direction of new drug research and development. In the land of material science, or change the surface properties of materials, give new energy, if the craftsman carves jade, it will bring new color to the material. Its application in various fields is like a star shining in the sky, and those who are waiting for research will explore it carefully, so as to develop its infinite ability and benefit the world.
Research & Development
In recent years, I have focused on the research of chemical products, especially 4-Methoxybenzenesulfonyl Fluoride. This substance has specific properties and is widely used.
At the beginning, the road to research was full of thorns. To understand its properties, it is necessary to fine measure and repeat experiments. From the selection of raw materials to the control of reactions, there must be no bad. All attempts, failure or success, are accumulated.
With unremitting efforts, gradually gains. In the field of medicine, it can be used as a key intermediate to help create new drugs; in materials science, it can also improve materials and increase their performance.
Looking to the future, when deepening research. Optimize the method of preparation, reduce its cost; Expand the field of application and improve its efficacy. We hope to continue to study, promote this product to shine in various fields, and pave a new path for research and development.
Toxicity Research
The chemical industry is related to people's livelihood, but the study of poisons in it cannot be ignored. Today there are 4-Methoxybenzenesulfonyl Fluoride, and I will explore its toxicity in detail.
The chemical nature of this substance is unique. In experiments, it is dangerous to touch the body or enter the body. It can disturb the cells and disrupt the order of physiology. The skin touches it, or it causes redness, swelling and tingling; if it enters the body, it will damage the functions of the organs, especially the liver and kidney.
Although it is useful in industry, the harm of toxicity cannot be prevented. Those who study this substance should strictly follow the procedures and prepare protective equipment to ensure their own safety. During the follow-up research period, it is possible to clarify its harm and control its risks, so that industrial use does not endanger human health.
Future Prospects
Today there is a thing called 4 - Methoxybenzenesulfonyl Fluoride. Looking at its nature, it can be used in all kinds of things, and it can show extraordinary ability. Although it is used at the moment, it is still limited to one side, but its future development can be looked forward to.
This substance is also used in the research of medical medicine, or it can be a new path for the treatment of diseases. With its uniqueness, it can explore the root cause of diseases and find a wonderful way to treat them. In the field of technology, it may also be the best choice for materials, assisting in the research of tools and materials, and promoting the refinement of craftsmanship.
Although the road ahead is long, with time, it will accumulate a few steps to a thousand miles, and it will accumulate small streams to form rivers and seas. I believe that it will be able to shine in the future world, be valued by everyone, and use it in all aspects.
Historical Development
4 - Methoxybenzenesulfonyl Fluoride, first appeared in the Western countries on the way to research medicine. At that time, many pharmacists studied pharmacology, hoping to get special agents. This compound has emerged, because of its unique properties, can block the activity of enzymes, and plays a pivotal role in biochemical reactions.
At the beginning, it was only a treasure in the laboratory for researchers to explore its properties. With the passage of time, science and technology have advanced, and its broad application has been known. In the field of medicine, it has gradually become a sharp blade for anti-disease, helping doctors overcome difficult diseases.
Looking at its process, from the discovery of micro-end to the importance of the medical community, it is like a jade that has been carved and finally shines. Its development has not been achieved overnight, but has been coagulated by researchers of all dynasties, contributing to the path of human health and making remarkable achievements.
Product Overview
4-Methoxybenzenesulfonyl fluoride is an exquisite chemical product. It may be a colorless liquid with specific physical and chemical characteristics. Looking at its structure, methoxy is connected to the benzene ring, and sulfonyl fluoro is also attached to the benzene ring. This unique structure gives it a unique character.
In various reactions, it can exhibit lively chemical activity and can interact delicately with many substances. In the field of organic synthesis, it is often used as a key reagent to help build novel compound structures, adding to the path of chemical exploration, enabling researchers to open up new frontiers and explore the unknown chemical world, so as to reach new heights of chemical research and inject fresh impetus into the development of chemistry.
Physical & Chemical Properties
4-Methoxybenzenesulfonyl fluoride has a very specific physical and chemical properties. Its shape or colourless liquid, and its taste is also unique. Looking at its melting point, the melting point is low, and it often shows a fluid state at low temperatures; the boiling point is higher, and it needs to be heated square boiling.
In terms of its solubility, it is quite soluble in organic solvents, such as ethanol and ether, but it is difficult to dissolve in water. Its density is higher than that of water, placed in water, and sinks under.
And its chemical activity is not weak, it is easy to react when exposed to alkali, and its bond is broken and its structure is changed. This characteristic makes it widely used in the fields of chemical industry and medicine. It can be used as a raw material, to produce other substances, and also to assist in the progress of reactions and the formation of new substances. It is related to the prosperity of the industry and cannot be ignored.
Technical Specifications & Labeling
Nowadays, there is 4-methoxybenzenesulfonyl fluoride, which is the key at the end of the process specification and identification (product parameters). The process specification needs to clarify the method of its preparation, from the use of raw materials, the accurate ratio, to the reaction conditions, such as temperature, duration, pressure, etc., should be detailed, so that the operator can follow and obtain a constant product.
In terms of identification (product parameters), the first thing to do is to determine its physicochemical properties, melting point, solubility, density, etc. And its purity and impurity content cannot be ignored. In this way, the user can make good use of the characteristics and quality of the product, and there is no risk of future problems. Process specifications and identification (product parameters) complement each other, ensuring the quality of 4-methoxybenzene sulfonyl fluoride.
Preparation Method
To prepare 4 - Methoxybenzenesulfonyl Fluoride, prepare the raw materials first. Take p-methoxybenzenesulfonic acid, this is the main raw material, its properties are stable and easy to buy. Fluorination reagents, such as potassium fluoride, are required to select those with high purity to ensure the best reaction effect.
The preparation process is as follows: In a clean reactor, put p-methoxybenzenesulfonic acid and an appropriate amount of solvent. The solvent is dichloromethane, because of its excellent solubility and easy separation. Stir well and heat up to a moderate, about 40-50 degrees Celsius. Slowly add potassium fluoride and stir while adding to make the reaction sufficient. This is the key step, temperature control and feeding speed, which is related to product purity.
The reaction process is monitored by thin layer chromatography. When the raw material point disappears, the reaction is complete. Cool, pour out the reaction solution, wash with sodium bicarbonate solution to remove impurities. Separate the liquid, and dry the organic phase with anhydrous sodium sulfate. Rotary evaporation removes the solvent to obtain a crude product. Then purified by column chromatography to obtain pure 4-Methoxybenzenesulfonyl Fluoride. The whole process, control all links, strictly observe the process, to obtain high-quality products.
Chemical Reactions & Modifications
4 - Methoxybenzenesulfonyl Fluoride, it is also a matter of transformation. Its transformation and reverse properties can be studied.

Its reverse properties, under specific conditions, can combine with matter, its process is exquisite, or there are new things to live. Among them, the rate and direction of reaction have their own laws. To improve its reverse properties, it is necessary to measure the degree, force, catalysis and other factors.

Its properties, 4 - Methoxybenzenesulfonyl Fluoride's properties, are not indeterminate. Or because of the environment, it develops different properties. For example, in contact with water or other solvents, the shape and activity of its molecules may change.
Therefore, when studying this transformed thing, it is necessary to observe its inverse properties in order to deeply understand it and use it for other things.
Synonyms & Product Names
4-Methoxybenzenesulfonyl fluoride, also known as methoxybenzenesulfonyl fluoride, is widely used in the field of chemical industry. It is often a key agent in organic synthesis, helping many reactions go smoothly.
Looking at the ancient books of chemical industry, although the ancient chemical industry did not directly describe this thing, it is deduced from today's reason. The evolution of chemistry is like a long river. Since the basic research in the past, new things have emerged one after another today. This 4-methoxybenzenesulfonyl fluoride is also the result of evolution.
Its nickname and trade name, although different, refer to the same. Chemical workers in the experiment, production, it must be carefully observed, because of the name of truth, in order to make good use of it. Such things, although invisible and useful, in the chemical industry, such as the boat to help navigation, as the basis of many processes, indispensable.
Safety & Operational Standards
4-Methoxybenzenesulfonyl fluoride safety and operating specifications
4-methoxybenzenesulfonyl fluoride, this substance is occasionally involved in chemical research. During its experimental operation, safety rules should first be kept in mind.
First, it is related to contact prevention. This compound has a certain chemical activity, so contact with the skin and eyes must be avoided. When operating, complete protective equipment is required, such as protective gloves, which must be made to resist the erosion of the substance; protective eye masks to protect the eyes from accidental spills. If you accidentally touch the skin, you should immediately rinse with plenty of water, and continue to rinse for not less than 15 minutes, and then seek medical treatment without delay. If it enters the eye, it is necessary to race against time to slowly rinse the eyes with flowing water, and at the same time rotate the eyeball to completely remove the foreign body, and then go to the ophthalmology department for treatment.
Second, the operating environment is also the key. It should be done in a well-ventilated experimental site. The best thing is to operate in a fume hood. This is to disperse harmful gases that may be volatilized during operation in time to ensure the safety of the experimenter's breathing. The performance of the fume hood needs to be regularly tested and maintained to ensure its ventilation and ventilation efficiency.
Third, the method of storage should not be underestimated. The substance should be stored in a cool, dry and ventilated place, away from fire and heat sources. Due to its chemical properties or reaction with certain substances, it needs to be stored separately from oxidants, reducing agents, alkalis, etc., and should not be mixed. The storage area should be equipped with suitable materials to deal with possible leakage accidents.
Fourth, operating specifications. When taking the compound, the utensils used must be clean and dry to prevent impurities from mixing in, affecting the experimental results, and avoiding unnecessary chemical reactions. The weighing process needs to be accurate, and the amount required for the experiment should not be increased or decreased at will. During the operation, be rigorous and meticulous to avoid spills, splashes, etc.
In short, in the research and operation of 4-methoxybenzenesulfonyl fluoride, safety and standards are as indispensable as the wings of a bird and the two wheels of a car. Only by strictly following these standards can we ensure the smooth operation of the experiment and the safety of personnel.
Application Area
4-Methoxybenzenesulfonyl fluoride has a wide range of uses. In biochemistry, it is often an inhibitor of serine protease. Enzymes are the hub of biochemical reactions, and serine protease is responsible for various physiological processes, such as blood coagulation and digestion. 4-Methoxybenzenesulfonyl fluoride, with its uniqueness, can stabilize the activity of serine protease, control its activity, and make the biochemical flow smooth.
And in the field of pharmaceutical research and development, it is also quite important. Can assist researchers to explore the mechanism of enzymes and pave the way for the creation of new drugs. For the treatment of diseases, blood coagulation or digestive diseases, if this agent can be used well, it can regulate the properties of enzymes, or relieve the suffering of patients. In the experiments of chemical biology, it is a sharp tool in the hands of researchers, and the function of protein assistance is the secret of biochemistry. Therefore, the use of 4-methoxybenzenesulfonyl fluoride in the fields of biochemical medicine shows its importance and great power.
Research & Development
Today there is a product called 4 - Methoxybenzenesulfonyl Fluoride. I am a chemical researcher and have been studying it for many years. This product has unique properties and has potential applications in many fields.
We investigated its reaction mechanism, and after repeated experiments, observed its role with various substances. It was found that under specific conditions, it can quickly combine with a certain type of compound to generate new substances, or open up new paths for material synthesis.
Looking forward to its development, if its reaction can be precisely controlled and the process can be optimized, it will be able to improve the yield and reduce its cost. In the future, it is expected to be widely used in medicine, materials and other industries, to promote the industry forward, to benefit the world, and to open up a new world in the path of scientific research.
Toxicity Research
Today there is a substance named 4 - Methoxybenzenesulfonyl Fluoride. As a chemical researcher, I have devoted myself to studying its toxicity. Although this substance is small, its toxicity cannot be underestimated.
Detailed investigation of its molecular structure and analysis of the mechanism of its reaction with other substances shows that it can interfere with the process of biochemistry in living organisms. After entering the body, or binding with proteins, it disrupts its normal function. After various experiments, it can be seen that the characterization and physiological changes of the tested organisms have an impact on the nervous, respiratory and other systems.
Although current research has been obtained, it still needs to be refined. To eliminate the root cause of its toxicity, understand its target of action, and explore the best strategy for protection and detoxification. In the hope that when people use this thing, they can avoid its harm and take advantage of it, so that the progress of science can be a blessing rather than a disaster.
Future Prospects
4 - Methoxybenzenesulfonyl Fluoride, it is also a thing of transformation. Now this thing, its nature is good, and it may be of great use in the field.
The outlook of the future, it is in the field of the world. Or it can be the foundation of the system, to help those who are sick and sick. And in the world of materials, it may also be new. Can make the material better, the performance is better, and it is generally needed.
And thinking about it in the path of scientific research, it will lead to the exploration of those who are new. Introduce new, unknown territory. In this way, 4 - Methoxybenzenesulfonyl Fluoride in the future will be like a star shining in the sky, shining brightly, and the steps of the world will be as good as it can be.
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Frequently Asked Questions

As a leading 4-Methoxybenzenesulfonyl Fluoride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the chemical structure of 4-Methoxybenzenesulfonyl Fluoride?
4 - Methoxybenzenesulfonyl Fluoride, it is also a chemical substance, and its chemical properties are specific. The core of this compound is the framework of benzene. Benzene, which is a six-membered carbon, is characterized by a special common carbon phase, showing a high degree of characterization.
In the benzene position, one of them has a methoxy group (-OCH). In the methoxy group, the oxygen atom is related to the carbon atom of the benzene group, and the distribution of the child cloud of the oxygen atom and the child cloud of the benzene group is affected, which can change the density of the child cloud of the benzene group, which affects the chemical activity of this compound.
The other one has benzenesulfonyl fluoryl group (-SO _ F). In this group, the sulfur atom is composed of the oxygen atom, the fluorine atom and the carbon atom of benzene. The high temperature of the sulfur atom makes this group have the ability to attract molecules, and the stability and reactivity of the whole molecule also play an important role.
The supply effect of methoxy group and the absorber effect of benzenesulfonyl fluoryl group check each other, and together determine the physical and chemical properties of 4-Methoxybenzenesulfonyl Fluoride, such as melting, boiling, solubility, reactivity, etc. This special property of the reagent makes it exhibit special properties in the reagent and engineering applications, and can be synthesized and reacted as well as in some special materials.
What are the main uses of 4-Methoxybenzenesulfonyl Fluoride?
4-Methoxybenzenesulfonyl fluoride has a wide range of uses. In the field of organic synthesis, it is often used as a sulfonylation reagent. It can react with various nucleophiles, such as alcohols and amines, to form corresponding sulfonate esters and sulfonamides. This reaction can effectively introduce sulfonyl functional groups when building the structure of organic molecules, and then endow the products with new physical and chemical properties. It is of great significance in pharmaceutical chemistry, materials science and many other aspects.
In the field of drug development, some sulfonamides prepared by the participation of 4-methoxybenzenesulfonyl fluoride in the reaction show good biological activity. For example, some drugs with such structures can act on specific enzymes or receptors, and are expected to become effective drug components for the treatment of diseases.
In material science, sulfonate polymers synthesized through their participation may have unique electrical and optical properties, which can be applied to many fields such as polymer materials and electronic devices. It imparts special properties to materials, such as improving the conductivity of materials and improving the stability of materials.
In addition, in the field of chemical analysis, 4-methoxybenzenesulfonyl fluoride can also be used as a special analytical reagent to identify or quantitatively analyze specific compounds. By means of specific reactions with target compounds, accurate detection of analytes can be achieved.
What are the physical properties of 4-Methoxybenzenesulfonyl Fluoride?
4-Methoxybenzenesulfonyl fluoride is a commonly used reagent in organic synthesis. Its physical properties are quite important and are related to many practical applications.
Looking at its properties, 4-methoxybenzenesulfonyl fluoride is mostly colorless to light yellow liquid at room temperature and pressure. This color state characteristic can be used as a preliminary judgment basis for laboratory identification and operation.
When it comes to boiling point, it is about a specific temperature range. The value of its boiling point is of great significance for experimental steps such as separation and purification. By controlling the temperature, according to the difference in boiling point, it can be effectively separated from the mixture to ensure the purity of the product.
Besides the melting point, although it is liquid at room temperature, the characteristics of the melting point cannot be ignored. The determination of the melting point helps to further confirm its purity. If it contains impurities, the melting point often changes.
The density of 4-methoxybenzenesulfonyl fluoride also has a specific value. In the process of solution preparation and reaction system construction, the density data is related to the accuracy of the dosage of substances, which directly affects the process and result of the reaction.
In terms of solubility, it has a certain solubility in common organic solvents such as some aromatics and halogenated hydrocarbons. This solubility characteristic determines the selection range of solvents in the synthesis reaction. Reasonable selection of solvents can make the reaction proceed smoothly and improve the reaction efficiency.
In addition, the volatility of 4-methoxybenzenesulfonyl fluoride is relatively moderate. It is neither extremely volatile and difficult to store and handle, nor is it difficult to remove from the system after the reaction due to weak volatility.
In summary, the various physical properties of 4-methoxybenzenesulfonyl fluoride, from color state, melting point, density to solubility and volatility, are related and critical. In the field of organic synthesis, it provides an important reference for experimenters to operate and design reactions, and is indispensable for achieving ideal experimental results.
What is the preparation method of 4-Methoxybenzenesulfonyl Fluoride?
For 4-methoxybenzenesulfonyl fluoride, the preparation method is as follows:
First take 4-methoxybenzenesulfonyl acid, which is the starting material for preparation. Place it in an appropriate reaction vessel, which needs to be clean and dry to prevent impurities from disturbing the reaction process.
Then, add an appropriate amount of chlorination reagent, such as phosphorus pentachloride or sulfinyl chloride. The function of this chlorination reagent is to convert the hydroxyl group in 4-methoxybenzenesulfonyl acid into a chlorine group to generate 4-methoxybenzenesulfonyl chloride. During the reaction, it is necessary to pay attention to the regulation of the reaction temperature, which is generally maintained in a moderate range, between about 50 and 80 degrees Celsius. At the same time, the stirring rate needs to be appropriate to allow the reactants to fully contact and promote the reaction.
After 4-methoxybenzenesulfonyl chloride is formed, it is separated and purified. Methods such as distillation and recrystallization can be used to obtain pure 4-methoxybenzenesulfonyl chloride.
Then, take the obtained 4-methoxybenzenesulfonyl chloride and transfer it to another reaction device. Add an appropriate amount of fluorination reagent, such as anhydrous potassium fluoride. This fluorination reagent can replace the chlorine group with a fluorine group, thereby generating 4-methoxybenzenesulfonyl fluoride. The temperature of this step should be controlled at about 100 to 120 degrees Celsius, and the reaction environment should be kept anhydrous and oxygen-free to prevent side reactions.
After the reaction is completed, the product is separated and purified. Impurities can be removed by column chromatography, vacuum distillation and other means to obtain high-purity 4-methoxybenzenesulfonyl fluoride. The whole preparation process requires careful operation at every step and strict control of the reaction conditions, so that high-quality products can be obtained.
What are the precautions for 4-Methoxybenzenesulfonyl Fluoride during use?
4-Methoxybenzenesulfonyl fluoride is a commonly used reagent in organic synthesis. When using it, there are several precautions that cannot be ignored.
Bear the brunt and safety is the most important. This reagent is toxic and corrosive, and contact with or inhalation of its vapors can cause physical damage. When operating, be sure to wear protective clothing, protective gloves and goggles, and do it in a well-ventilated environment. If possible, use a fume hood to prevent vapor accumulation and endanger the human body.
Furthermore, its chemical properties are active. 4-Methoxybenzenesulfonyl fluoride reacts easily with nucleophiles, is unstable in contact with water, and can hydrolyze to form sulfonic acid and hydrofluoric acid. Therefore, when storing, it is necessary to seal it in a dry and cool place, away from water sources and active nucleophilic reagents, such as amines, alcohols, etc., to prevent gratuitous reactions and deterioration of the reagents.
In addition, in the reaction system, precise temperature control and quantity control are required. If the temperature is too high, or the amount of reagents is inappropriate, the reaction can be out of control and by-products can be formed, which affects the yield and product purity. When the reaction mechanism and the expected product are used, the reaction conditions are carefully optimized to make the reaction proceed smoothly.
In addition, the post-reaction treatment should not be underestimated. Because the reaction products or residual reagents may be toxic and corrosive, the waste should be properly disposed of according to regulations and should not be dumped at will to avoid polluting the environment. And in the process of reaction and post-treatment, safety should also be paid attention to to prevent potential dangers.
In short, when using 4-methoxybenzene sulfonyl fluoride, care should be taken in terms of safety, storage, control of reaction conditions and post-treatment, in order to ensure the smooth operation of the experiment and achieve the desired purpose.