4-Hydroxybenzotrifluoride

Duxiu Chemical

Specifications

HS Code	464554
Chemical Formula	C7H5F3O
Molecular Weight	162.11
Appearance	Colorless to light yellow liquid
Boiling Point	189 - 191 °C
Melting Point	17 - 19 °C
Density	1.339 g/mL at 25 °C
Vapor Pressure	0.36 mmHg at 25 °C
Flash Point	76 °C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, ether

As an accredited 4-Hydroxybenzotrifluoride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	1 kg of 4 - Hydroxybenzotrifluoride packaged in a sealed, corrosion - resistant container.
Storage	4 - Hydroxybenzotrifluoride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in tightly closed containers to prevent moisture absorption and evaporation. Label the storage containers clearly. Follow safety regulations to ensure proper storage and avoid potential hazards.
Shipping	4 - Hydroxybenzotrifluoride, a chemical, is shipped in carefully sealed, corrosion - resistant containers. Special handling protocols are followed to prevent spills. Shipment adheres to strict hazardous material regulations for safe transit.

Free Quote

Competitive 4-Hydroxybenzotrifluoride prices that fit your budget—flexible terms and customized quotes for every order.

For samples, pricing, or more information, please call us at +8615371019725 or mail to sales7@bouling-chem.com.

We will respond to you as soon as possible.

Tel: +8615371019725

Email: sales7@bouling-chem.com

General Information

Historical Development

4 - Hydroxybenzotrifluoride, the development of this thing, although ancient times did not know much about it, but the evolution of science and technology, its traces are gradually emerging. In the past, chemical exploration was just beginning, and the understanding of fluoride was still shallow. After the study of various sages, organic fluorine chemistry gradually became a system.
To modern times, scientific research has advanced, and the method of 4-Hydroxybenzotrifluoride synthesis has been created. At first, it was obtained by difficult methods, and the yield was not high. However, scholars made unremitting efforts to improve the process and optimize the process. Then it made its preparation more convenient and the yield gradually improved.
At present, this compound has emerged in the fields of medicine, materials and other fields, and its use is becoming more and more widespread. Its historical evolution is a testament to the development of science and technology and the study of scholars, and the future will be even more promising.

Product Overview

4 - Hydroxybenzotrifluoride, the chemical product is also. Its physical properties are specific, the color is pure and pure, often in the form of a colorless liquid, the appearance is clear like glass, and the smell is also unique. It has a wide range of uses in the field of chemical industry and is a key raw material for many synthesis reactions. Its molecular structure is exquisite, based on benzene ring, with hydroxyl groups and trifluoromethyl groups on it, and the interaction between the two gives it a unique chemical activity. With this characteristic, it can be used as an intermediate in the synthesis of medicine to help create a variety of special drugs; in the research and development of materials, it can also add its unique properties, so that the quality of the material can be sublimated. Although it is small, it has an indispensable position in the progress of the chemical industry and is sincerely a treasure in the chemical industry.

Physical & Chemical Properties

4 - Hydroxybenzotrifluoride, it is also a matter of transformation. Its properties are both physical and chemical. As far as physical properties are concerned, under normal conditions, or solid, or liquid, the color is transparent or slightly light, and it has a special taste. Melting and boiling have their own specifications, which can be determined. Its density also has a specific value, and it is necessary for the mixing and division of materials.
It has chemical properties, because it contains specific functional groups, it has phase chemical activity. It can cause multiple reactions, such as nuclear substitution, nuclear substitution, etc. This is determined by the atomic arrangement and molecular cloud composition in its molecules. And the rate of transformation and reaction is also different due to the reaction, catalysis, etc. In addition, the physical and chemical properties of 4-Hydroxybenzotrifluoride are important in fields such as chemical research, engineering and biology.

Technical Specifications & Labeling

4 - Hydroxybenzotrifluoride, the quality of the product is also important. The quality of the product (commodity quality) is very important. The workmanship of the product needs to be refined and studied to make the material matching appropriate. Such as the control of quality and strength, it is all about the quality of the product.
The quality of the product, the composition and characteristics of the product, and the user knows its nature, so as to use it. The quality of the product is also the same, such as the quality and the external quality, all fit together. The quality of the product, the high quality of the product, and the external quality must also be complete and complete. In this way, the quality of the 4-Hydroxybenzotrifluoride product (commodity quality) is correct, so that the user can make it work well.

Preparation Method

4 - Hydroxybenzotrifluoride is an important compound in organic synthesis. The preparation method is related to the raw materials and production process, reaction steps, and catalytic mechanism. The selection of raw materials, fluorinated aromatics and phenolic derivatives are commonly used, and the ratio is accurate according to the reaction characteristics. In the production process, halogenation, hydrolysis, fluorination and other steps. During halogenation, a specific halogenating agent is selected to halogenate aromatics, and the conditions need to be precisely controlled. During hydrolysis, the appropriate alkali-based halogenate is converted into phenolic hydroxyl groups. Fluorination uses fluorine-containing reagents to form the desired fluorinated structure. The reaction steps are orderly and interlocked step by step. In the catalytic mechanism, the appropriate catalyst, such as metal salts or organic bases, is selected to accelerate the reaction and yield. This preparation method needs to be carefully controlled in each link to obtain 4-Hydroxybenzotrifluoride efficiently.

Chemical Reactions & Modifications

Taste the wonders of chemistry, endless changes, related to the properties and transformations of substances. Today, in terms of 4-Hydroxybenzotrifluoride this substance, its chemical reaction and modification are essential.
In the way of reaction, we should seek precision and efficiency. When this compound participates in the reaction, or due to different conditions, the products are different. Temperature, solvent, catalyst are all key. In order to obtain a good effect, fine regulation is required to make the reaction follow the ideal path and avoid the disadvantages of dissimilation.
As for the modification method, it is designed to improve its performance. Or add functional groups to change its polarity and activity; or adjust the molecular structure to increase its stability and applicability. In this way, it can be broadened and used in the fields of medicine and materials.
Therefore, as a chemical researcher, when we study the reaction and modification of 4-Hydroxybenzotrifluoride, we will make unremitting exploration to improve the environment and contribute to the progress of chemistry, so that this compound can play a greater role.

Synonyms & Product Names

4 - Hydroxybenzotrifluoride, this substance is also known as p-trifluoromethylphenol. In the course of my chemical research, I well know that the same substance has many names, which is due to differences in industry habits and uses.
In the past, chemistry was in its infancy, and there was still a lack of standardization in naming, and many substances were called according to their properties and sources. Just like p-trifluoromethylphenol, because it contains trifluoromethyl and phenolic hydroxyl groups, and hydroxyl groups are in alignment with phenyl rings, so it gets this scientific name. However, in chemical practice, craftsmen may give it another name according to their uses and synthesis methods.
Nowadays, science is prosperous, and naming standards are gradually improving, but the old name still exists in some fields. Trifluoromethylphenol has made great contributions to the synthesis of medicine and pesticides, or due to the unique process of a pharmaceutical company, it is given a special trade name, which has spread and become known in the industry. Although the names are mixed, researchers all know that it is the same thing, which is the embodiment of the inheritance and development of chemical research.

Safety & Operational Standards

4-Hydroxytrifluorotoluene, the preparation and application of this substance are related to safety and operating standards, and are of paramount importance.
When preparing, the required utensils must be clean and dry to prevent impurities from mixing and affecting the purity of the product. In the reaction vessel, precisely control the dosage of the reactant, follow the established ratio, and do not make a slight difference. The reaction temperature and time also need to be strictly controlled. If there is a deviation between the two, the reaction may be incomplete or by-products may be formed.
During operation, protective measures are essential. Experimenters should wear protective clothing, goggles and gloves to prevent the substance from coming into direct contact with the body. Because it is corrosive to a certain extent, if it accidentally touches the skin, it should be rinsed with a large amount of water immediately, followed by medical treatment.
When storing, it should be placed in a cool, dry and well-ventilated place, away from fire sources and oxidants. Because of its lively nature, it may be exposed to heat or oxidants, or there is a risk of combustion or explosion.
When transporting, it is also necessary to strictly abide by the specifications. Choose suitable packaging materials to ensure good sealing to prevent leakage. During transportation, avoid violent vibration and collision to prevent package damage.
In conclusion, the entire process of 4-hydroxytrifluorotoluene, from preparation, operation, storage to transportation, must strictly adhere to safety and operating standards, so as to ensure the safety of personnel and the smooth progress of experiments and production.

Application Area

4 - Hydroxybenzotrifluoride, its application field is quite wide. In the field of medicine, it can be used as a key intermediate to help create a variety of special drugs, or to cure various diseases, adding a sharp tool for doctors to cure diseases and save people. In the field of pesticides, it can help develop high-efficiency pesticides, protect crops to control pests, and ensure the harvest of five grains. And in the field of materials, it also has its own uses, which can optimize material properties and make it more durable. If this compound can be used well, it will shine in various industries and benefit all people. It is a chemical substance that cannot be underestimated.

Research & Development

In recent years, I have focused on the research of 4-Hydroxybenzotrifluoride. This compound has unique properties and wide application, and has great potential in many fields.
At the beginning, I explored its synthesis path, tried many times, and experienced twists and turns. The traditional method is either expensive or the yield is not good. I studied day and night, consulted ancient books and this book, visited various houses, and finally got an optimization strategy to make the synthesis more efficient.
Synthesis is stable, but its performance is observed. In experiments, its physical and chemical properties are carefully measured, data are recorded, and repeated verification. Its performance in specific reactions is particularly eye-catching, paving the way for subsequent applications.
At present, the results have been pushed to the industry, hoping to contribute to the development of the industry. In the future, it will also be deeply cultivated to expand its application boundaries, hoping to make more breakthroughs, contribute to the academic community, and promote long-term progress in this field.

Toxicity Research

4 - Hydroxybenzotrifluoride, it is also the thing that dissolves. I have studied the toxicity of this thing for a long time. Now, let's use the method to reduce its properties.
Take this thing first, and use the white rat to reduce it. If the white rat eats it or does not eat it, it shows that it has a certain toxicity.
If its liquid is applied to the plant, the plant will be colored and blocked, and the toxicity is also clear.
And analyze its chemical production, and investigate the root cause of its toxicity. Or because it contains a special foundation, it is easy to cause the reaction of biological substances, which is the order of its physiology.
However, if you want to understand its effectiveness, you still need to use it in many ways and observe it in order to get it, know the depth of its toxicity and the reason of its effect, so as to avoid its harm and use it for its benefit.

Future Prospects

Guanfu 4 - Hydroxybenzotrifluoride this thing, its unique nature, a wide range of uses. In today's world, science and technology are new, in the chemical industry, its emergence, and gradually re-position.
Our generation expects its future, will shine. Chemical manufacturing, seeking efficient and pure materials, this product is at the right time, or can optimize the process, increase output. Pharmaceutical research and development, exploring the method of precise healing, which may be a key element to help solve the difficulty of disease.
And the tide of environmental protection is surging, if this substance is used ingeniously, it may be able to take a new path in the way of green chemistry. The future exhibition, such as the migration of Peng in Nanming, will rise up with infinite potential, and is expected to be the driving force for the transformation of all industries, the unfinished grand cause, and the vision of everyone.

Where to Buy 4-Hydroxybenzotrifluoride in China?

As a trusted 4-Hydroxybenzotrifluoride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 4-Hydroxybenzotrifluoride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-Hydroxybenzotrifluoride?

4-Hydroxytrifluorotoluene, which has a wide range of uses. In the field of medicine, it is a key intermediate. Due to the structure of trifluoromethyl, it can significantly change the physical, chemical and biological activities of compounds. Based on this, a variety of specific drugs can be synthesized, such as some agents with high antibacterial and antiviral properties, which can precisely act on pathogens, block their metabolism or reproduction pathways, and help the human body resist disease attacks.
In the field of pesticides, it is also an indispensable raw material. The pesticides produced often have excellent insecticidal and herbicidal activities, and are environmentally friendly, with low residues. Due to the special properties of trifluoromethyl, such pesticides can quickly penetrate the epidermis or weed tissue of pests, and exert their effectiveness, while reducing the impact on non-target organisms and maintaining ecological balance.
In the field of materials science, 4-hydroxytrifluorotoluene also has outstanding performance. It can be used to prepare high-performance polymer materials, such as special engineering plastics. With its unique structure, it endows the material with excellent heat resistance, chemical corrosion resistance and mechanical properties, making it widely used in high-end fields such as aerospace, electronics and electrical appliances. In aerospace, it can be used as a component material for aircraft to withstand extreme environments; in electronic appliances, it can be used to manufacture high temperature and corrosion-resistant electronic components to ensure stable operation of equipment.

What are the physical properties of 4-Hydroxybenzotrifluoride?

4-Hydroxytrifluorotoluene, the physical properties of which are as follows:
This substance is usually colorless to light yellow liquid at room temperature. Looking at its appearance, it is clear and fluid. Its melting point is about 16-20 ° C. When the temperature drops below the melting point, it gradually condenses from liquid to solid. The boiling point is 220-222 ° C. If the temperature rises to the boiling point and above, it will transform into a gaseous state.
Its density is about 1.38 g/cm ³, which is higher than that of water, so if mixed with water, it will sink to the bottom of the water. 4-Hydroxytrifluorotoluene is slightly soluble in water, but it can be miscible with common organic solvents, such as ethanol, ether, acetone, etc., in any ratio. Because it has a similar molecular structure and polarity to these organic solvents, it conforms to the principle of "similar miscibility".
Its low vapor pressure means that at room temperature, the degree of volatilization is relatively small. However, if the ambient temperature increases, the vapor pressure will also increase, and the volatilization rate will accelerate. This substance has a certain refractive index, about 1.475-1.480. When light passes through this substance, it will refract. This property may have certain significance in the research and application of optics.
In addition, 4-hydroxytrifluorotoluene has a special odor, which is difficult to describe accurately, but can be distinguished. When storing and using, it is necessary to pay attention to its odor emission, because it may cause certain irritation to the human respiratory tract. Understanding these physical properties has important guiding value for the operation, storage and application of 4-hydroxytrifluorotoluene in many scenarios such as chemical production and scientific research experiments.

What are 4-Hydroxybenzotrifluoride synthesis methods?

4-Hydroxytrifluorotoluene has been synthesized by various methods throughout the ages.
First, trifluoromethylbenzene is used as the starting material. After halogenation, a halogen atom is introduced onto the benzene ring. Commonly used halogenating agents such as bromine and chlorine can be obtained under suitable reaction conditions. After nitration, a mixed acid system of concentrated nitric acid and concentrated sulfuric acid is used to introduce the nitro group into a specific position in the benzene ring. Next, the nitro group is reduced to an amino group, which can be combined with iron powder, zinc powder and other metals and hydrochloric acid, or a catalytic hydrogenation method is used. Finally, the amino group is converted into a hydroxyl group through diazotization hydrolysis, resulting in 4-hydroxytrifluorotoluene. There are many steps in this route, but the reaction conditions in each step are relatively clear, and there are many experiences to follow in operation.
Second, p-hydroxybenzoic acid is used as the raw material. First, the carboxyl group is esterified, and the corresponding ester is formed by alcohol and acid under the action of the catalyst. Then, the benzene ring is trifluoromethylated with fluorine-containing reagents, such as trifluoroacetic anhydride. This reaction needs to be carried out under specific reaction solvent and base catalysis conditions. Finally, through the ester hydrolysis reaction, the ester group is re-converted into a carboxyl group, and then through the decarboxylation reaction, the target product 4-hydroxytrifluorotoluene can be obtained. The raw materials used in this route are relatively common, and the selectivity of some steps is good, which can effectively reduce the occurrence of side reactions.
Third, trifluoromethylphenol is used as raw material. Through selective protection of hydroxyl groups, suitable protective groups, such as silicon ether protective groups, can be selected. After protection, through a specific electrophilic substitution reaction, suitable substituents are introduced, and then the protective groups are removed to restore the hydroxyl groups, and finally 4-hydroxytrifluorotoluene can be obtained. This method focuses on the protection and deprotection strategies of hydroxyl groups. It is widely used in the field of fine synthesis, which can better control the reaction check point and improve the purity of the product.
These synthesis methods have their own advantages and disadvantages. It is necessary to consider the availability of raw materials, cost, difficulty of reaction conditions and product purity and many other factors according to actual needs.

What is the price range of 4-Hydroxybenzotrifluoride in the market?

The price range of 4-hydroxytrifluorotoluene in the market is difficult to determine. There are many reasons for it. This compound has a wide range of uses and is involved in various fields such as medicine, pesticides, and materials. Different uses have different requirements for its quality and purity, and the price will vary.
In terms of purity, if it is a general industrial grade purity, its price may be slightly lower; if it is a high purity, such as a high purity product used in pharmaceutical research and development, the price will be high. Looking at past market conditions, the price of industrial grade 4-hydroxytrifluorotoluene per kilogram may be in the range of hundreds of yuan; while the price of pharmaceutical grade high purity can reach tens of yuan or even higher per gram, and the conversion price per kilogram is tens of thousands of yuan is unknown.
Furthermore, the following pair of market supply and demand have a huge impact on its price. If there is a large increase in demand at a certain time and the supply is limited, the price will rise; conversely, if there is an excess supply and the demand is weak, the price will fall. And the fluctuation of raw material prices, the difficulty of production processes, transportation costs and other factors all affect its market price. In order to know the exact price range, it is necessary to visit the chemical raw material market in real time, consult suppliers, and comprehensively consider all factors to obtain a more accurate price.

4-Hydroxybenzotrifluoride What are the precautions during storage and transportation?

4-Hydroxytrifluorotoluene is an important raw material for organic synthesis. During storage and transportation, many matters need to be paid careful attention.
When storing it, the first choice of environment. It should be placed in a cool and ventilated place, because the substance is prone to chemical reactions when heated, resulting in damage to its stability. The warehouse temperature should be strictly controlled, not too high, so as not to promote its decomposition or cause other dangerous changes. And it needs to be kept away from fire and heat sources. Open flames and hot topics are hidden dangers that cause accidents.
Furthermore, the storage place should be kept dry. 4-Hydroxytrifluorotoluene may react chemically in contact with water or moisture, so moisture protection is essential. A desiccant can be placed around the storage container to prevent moisture from invading.
The choice of storage container should not be ignored. A well-sealed container should be used to prevent it from evaporating or reacting with air components. Containers made of common glass or metal materials should not be used if the seal is not good.
As for the transportation process, it is necessary to ensure that the packaging is complete. If the packaging is damaged, 4-hydroxytrifluorotoluene or leakage will pollute the environment and endanger the safety of transportation personnel. The transportation vehicle should be selected as suitable. The vehicle should be clean and dry, and there should be no residue of substances that may react with it.
During transportation, avoid vibration, impact and friction. Violent vibration or damage to the container, impact and friction or static electricity generation may cause danger. Transport personnel also need to undergo professional training to be familiar with the characteristics of the substance and emergency treatment methods. In case of emergencies, they can be handled quickly and properly to ensure safe transportation.