As a leading 4-Hydroxybenxotrifluoride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-Hydroxybenxotrifluoride?
4-Hydroxytrifluorotoluene has a wide range of uses. In the field of medicine, it is a key intermediate for the preparation of a variety of drugs. For example, some antimicrobial drugs and anti-inflammatory drugs with specific curative effects need to be used as starting materials or important intermediates in the synthesis process. With its unique chemical structure, it participates in the reaction to construct drug active ingredients, and then exerts pharmacological effects.
In the field of pesticides, it is also an important component in the synthesis of high-efficiency pesticides. The creation of some pesticides and herbicides relies on 4-hydroxytrifluorotoluene. Due to its structure, pesticides have unique physical and chemical properties and biological activities, which can effectively kill pests, inhibit the growth of weeds, and help agricultural production.
In the field of materials science, it also shows important value. It can be used to prepare special polymer materials. After chemical modification or polymerization, it can be introduced into the polymer structure to impart special properties such as weather resistance, chemical corrosion resistance, and low surface energy to the material. It is used in aerospace, automobile manufacturing, construction, and other industries that require strict material properties.
Furthermore, in the study of organic synthesis chemistry, it is often used as a building block for organic synthesis. Because it contains two types of active functional groups, hydroxyl groups and trifluoromethyl groups, many organic compounds with different structures can be derived through various chemical reactions, such as esterification, etherification, nucleophilic substitution, etc., providing a rich material basis and diverse synthesis paths for the development of organic synthesis chemistry.
What are the physical properties of 4-Hydroxybenxotrifluoride?
4-Hydroxytrifluorotoluene, this substance is colorless to light yellow liquid with a special odor. Its melting point is remarkable, the melting point is about 40-43 ° C, and the boiling point is between 220-222 ° C. Due to the special structure of the intramolecular hydroxyl group and trifluoromethyl group, it has a certain polarity and has good solubility in organic solvents. Like common organic solvents such as ethanol, ether, and acetone, it can be miscible with it, but the solubility in water is relatively small.
Looking at its stability, it is relatively stable at room temperature and pressure. However, when encountering open flames or hot topics, there is a risk of combustion. And the decomposition of hot topics will release toxic gases containing fluorine and sulfur, so caution must be used when storing and using.
The density of this substance is greater than that of water, about 1.44g/cm ³, and the vapor pressure has a corresponding value under specific conditions, which affects its behavior in the gas phase. In the field of organic synthesis, 4-hydroxytrifluorotoluene has a unique structure and is often used as a key intermediate. It participates in the synthesis process of many drugs, pesticides and fine chemicals, and is an important raw material for organic synthetic chemistry.
Is 4-Hydroxybenxotrifluoride chemically stable?
4-Hydroxytrifluorotoluene, its chemical properties are relatively stable. This substance contains trifluoromethyl. Due to the extremely high electronegativity of fluorine atoms, trifluoromethyl has a strong electron-withdrawing effect, which affects the distribution of molecular electron clouds. The hydroxyl groups on the benzene ring interact with it, affecting its chemical activity.
Under normal conditions, 4-hydroxytrifluorotoluene can exist stably in mild environments. In case of strong oxidizing agents, the hydroxyl groups may be oxidized, such as in contact with strong oxidizing substances such as potassium permanganate under suitable conditions, and the hydroxyl groups may be converted to carbonyl groups or even carboxyl groups.
However, in view of the strong electron-absorbing properties of trifluoromethyl, the electron cloud density of benzene ring decreases, so that the electrophilic substitution activity of benzene ring decreases compared with benzene, and it is less prone to electrophilic substitution reactions such as halogenation and nitrification. However, under specific conditions and suitable catalysts, electrophilic substitution reactions can still occur. The substitution position is jointly dominated by the electronic effect of hydroxyl groups and trifluoromethyl groups. Because hydroxyl groups are ortho-para-sites and trifluoromethyl groups are meta-sites, in general, the reaction tends to occur in the ortho or para-sites of hydroxyl groups.
In terms of nucleophilic substitution reactions, due to the influence of trifluoromethyl groups, its reaction activity is different from that of general halogenated aromatics, and specific conditions and
Overall, 4-hydroxytrifluorotoluene is stable under common conditions, but under the action of specific chemical environments and reagents, it can undergo specific chemical reactions and exhibit unique chemical behaviors.
What is 4-Hydroxybenxotrifluoride production method?
In the past, there were many different methods for the preparation of 4-hydroxytrifluorotoluene. The common one is to use p-cresol as the starting material and first use a specific reagent to sulfonate. The sulfonating agent such as p-cresol and sulfuric acid is interacted with at a suitable temperature and time to obtain a sulfonated product.
Then, the sulfonated product is reacted with a fluorinated reagent. This fluorinated reagent, or potassium fluoride, is obtained by replacing the sulfonate group with a fluorine atom under the help of a high temperature and a phase transfer catalyst.
The method of re-oxidation selects a suitable oxidizing agent, such as potassium permanganate, potassium dichromate, etc., in a suitable acid-base environment, temperature and other conditions, the methyl of p-fluorotoluene is oxidized to a carboxyl group to obtain p-fluorobenzoic acid.
Finally, the carboxyl group of p-fluorobenzoic acid is reduced to a hydroxyl group with a specific reducing agent, such as lithium aluminum hydride, etc., to obtain 4-hydroxytrifluorotoluene.
There is another method, starting with p-chlorotrifluorotoluene. React it with alkali metal hydroxide in a system of high temperature and high pressure, phase transfer catalyst, and the chlorine atom is replaced by a hydroxyl group, and 4-hydroxytrifluorotoluene can also be obtained. These two methods have their own advantages and disadvantages, and they are both common ways to prepare 4-hydroxytrifluorotoluene.
What is the price range of 4-Hydroxybenxotrifluoride in the market?
4-Hydroxytrifluorotoluene, in the market price range, varies depending on time and place supply, demand and quality. Looking at the market of chemical materials in the past, the price of such fine chemicals is influenced by many factors.
When it comes to the cost of raw materials, if the initial materials required for their preparation, such as fluorinated compounds and phenols, are abundant in sources and stable in price, the price of 4-hydroxytrifluorotoluene may stabilize. On the contrary, if raw materials are scarce, difficult to mine or affected by policy regulation, the cost will rise, and its market price will also rise.
Furthermore, the difficulty and advanced level of production technology are also key. If the process is complex, requires high-end equipment and fine operation, and consumes a lot of energy, the production cost will be high, and the price will be high. However, if the process is improved, the efficiency will be improved, and the loss will be reduced, the price may be reduced.
The supply and demand relationship in the market is more like leverage in the trade-off. When the market has strong demand for 4-hydroxytrifluorotoluene, which is widely used in industries such as medicine, pesticides and materials, and the demand exceeds the supply, the price will rise. On the contrary, if there is excess capacity and the demand is weak, the price will fall.
Based on the rough estimate of past market conditions, the price per kilogram may be between hundreds and thousands of yuan. For high-quality products that meet high-end application standards, the price may be nearly several thousand yuan per kilogram; for ordinary industrial-grade products, it may be several hundred yuan per kilogram. However, this is only a rough estimate. The actual price must be carefully checked by the current market conditions and consulted with industry merchants, chemical trading platforms and relevant professionals before the exact number can be obtained.