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What are the main uses of 4-Fluoro-3-Aminobenzotrifluoride?
4-Fluoro-3-aminotrifluorotoluene has a wide range of uses. In the field of medicine, it is a key organic synthesis intermediate, and many new drug research and development rely on it to build specific molecular structures. In pharmaceutical chemistry, specific functional group combinations are the main factors that determine drug activity and selectivity. The fluorine atoms, amino groups and trifluoromethyl groups of 4-fluoro-3-aminotrifluorotoluene can endow drugs with unique physicochemical properties, such as improving drug fat solubility, facilitating its penetration through biofilms, and enhancing bioavailability; and can affect the interaction between drugs and targets to improve efficacy.
It is also an important starting material in the creation of pesticides. Modern pesticides pursue high efficiency, low toxicity and environmental friendliness. The structure of this compound can be modified to develop insecticides, fungicides or herbicides. For example, its unique chemical structure may precisely act on the specific physiological processes of pests, interfere with the growth and development of pests or nervous system functions, and achieve the purpose of efficient insecticide. At the same time, it has low toxicity to non-target organisms, which is in line with the current needs of green agriculture development.
In the field of materials science, 4-fluoro-3-amino trifluorotoluene has also emerged. When synthesizing functional polymer materials, the introduction of this structural unit can endow the materials with special properties. Such as the preparation of fluoropolymers, due to the high electronegativity of fluorine atoms, can enhance the chemical stability, weather resistance and surface properties of polymers, used in high-end coatings, special plastics, etc., to improve material quality and application range.
In short, 4-fluoro-3-aminotrifluorotoluene, with its unique chemical structure, plays a key role in the fields of medicine, pesticides and materials science, and promotes technological innovation and product upgrading in various fields.
What are the physical properties of 4-Fluoro-3-Aminobenzotrifluoride?
4-Fluoro-3-aminotrifluorotoluene is an organic compound. Its physical properties are quite characteristic, let me tell them one by one.
First of all, its appearance, at room temperature and pressure, is mostly colorless to light yellow liquid, clear and with a certain fluidity. Looking at it, light is transparent, which is a significant feature of its appearance.
The second and boiling point is about 180-182 ° C. When the temperature reaches this point, the substance gradually converts from liquid to gaseous, the intermolecular forces are overcome, and it begins to boil and evaporate. The characteristics of boiling point are particularly critical in separation, purification experiments and industrial operations.
In addition, the melting point is usually close to about -20 ° C. When the temperature drops, the molecular movement slows down, and the attractive force between them makes the substance solidify from liquid to solid. The value of the melting point is related to the physical form of the substance at different ambient temperatures.
Its density is about 1.4 g/cm ³, which is slightly higher than the density of water at 1 g/cm ³. Therefore, if mixed with water, it will sink underwater.
Solubility is also an important physical property. In organic solvents such as ethanol and ether, 4-fluoro-3-aminotrifluorotoluene is soluble, but it has little solubility in water. This is due to the molecular structure of the compound, which makes it have a strong interaction with organic solvent molecules and a weak interaction with water molecules.
In addition, this compound has a certain volatility, can be slowly dissipated in the air, and has a certain odor. Although it is not pungent and unpleasant, it should also be paid attention to. In summary, the physical properties play a key guiding role in the application of 4-fluoro-3-aminotrifluorotoluene in the fields of chemical synthesis and material preparation.
Is 4-Fluoro-3-Aminobenzotrifluoride chemically stable?
The chemical stability of 4-fluoro-3-aminotrifluorotoluene is related to many aspects. This compound contains fluorine, amino and trifluoromethyl groups. Fluorine atoms have strong electronegativity, which can stabilize the molecular structure. The radius of fluorine atoms is small, and the effect of steric hindrance is relatively small.
Trifluoromethyl also has a unique effect. Its strong electron absorption can change the distribution of molecular electron clouds and affect the reactivity of compounds. In this molecule, the presence of trifluoromethyl may reduce the electron cloud density of the benzene ring, making it difficult to cause electrophilic substitution reactions, which improves stability to a certain extent.
However, the presence of amino groups has different effects. Amino groups act as power supply groups, which can increase the electron cloud density of the benzene ring, making the benzene ring more prone to electrophilic substitution reactions, or weakening the overall stability.
In general environments, 4-fluoro-3-aminotrifluorotoluene is relatively stable without specific conditions. In case of extreme conditions such as high temperature, strong oxidizing agent or strong reducing agent, its stability may be challenged. At high temperature, the intra-molecular energy increases, and the vibration of chemical bonds intensifies, which may lead to bond fracture and rearrangement. Strong oxidizing agents can oxidize groups such as amino groups, and strong reducing agents can also react with specific groups to cause structural changes.
In summary, the stability of 4-fluoro-3-aminotrifluorotoluene is not absolute, and it is relatively stable under common mild conditions, but it will be shaken under special severe conditions.
What is the production process of 4-Fluoro-3-Aminobenzotrifluoride?
The production process of 4-fluoro-3-aminotrifluorotoluene is a key technology in chemical manufacturing. The method is as follows:
Starting material, aromatic hydrocarbons containing fluorine and trifluoromethyl are often selected. First, the aromatic hydrocarbons are halogenated with specific halogenating reagents, such as halogen elements catalyzed by iron halide, and halogen atoms are introduced at suitable positions. This step requires precise temperature control, time control and reagent ratio regulation to ensure the accuracy of halogenation check points.
Then, through nitrification reaction, nitro groups are introduced at another suitable position of aromatic hydrocarbons. The nitrifying reagents used are mostly mixed acids (mixtures of concentrated sulfuric acid and concentrated nitric acid), during which temperature, reaction time and mixed acid concentration have a great influence on the selectivity and yield of nitrification products.
After obtaining the intermediate containing halogen atom and nitro group, the nitro group is converted to amino group by reduction means. Common reduction methods include catalytic hydrogenation, using precious metals or nickel as catalysts, under suitable hydrogen pressure and temperature, to reduce nitro groups to amino groups; chemical reduction methods can also be used, such as iron powder, zinc powder and other metals and acid systems to reduce nitro groups.
At the same time, for the halogen-containing atom part, the halogen atom can be replaced by a fluorine atom by a nucleophilic substitution reaction. According to specific conditions and nucleophilic reagents, the halogen atom can be replaced by a fluorine atom. Factors such as the type and dosage of solvent and base need to be carefully considered.
After each step of the reaction, the product must be separated and purified. Column chromatography, recrystallization and other methods are often used to remove impurities and obtain high-purity 4-fluoro-3-aminotrifluorotoluene. Throughout the production process, precise control of the reaction conditions and standardized implementation of each step are the keys to high-quality products.
What is the price range of 4-Fluoro-3-Aminobenzotrifluoride in the market?
The price range of 4-fluoro-3-aminotrifluorotoluene in the market is difficult to say exactly. This is due to the rapidly changing market conditions and is influenced by many factors.
First, the situation of supply and demand is deeply affected. If there are many people who want it, and the supply is small, the price will increase; conversely, if the supply exceeds the demand, the price may drop. Second, the price of raw materials is also key. Its preparation requires specific raw materials, and the fluctuation of raw material prices directly affects the cost of 4-fluoro-3-aminotrifluorotoluene, which in turn affects the price. Furthermore, the art of production also plays a role. Efficient and low-cost processes can make products more price competitive.
Looking at the market conditions of the past, the price of this product fluctuates a lot. At some times, or due to abundant raw materials and advanced craftsmanship, the price is slightly lower, per kilogram or in the range of several hundred yuan; however, at other times, due to the scarcity of raw materials and the surge in demand, the price may rise to several thousand yuan per kilogram.
If you want to know the exact price, you should consult the chemical raw material supplier, or check it in detail on the relevant chemical trading platform. Because it changes with market conditions, only real-time information can determine the price.