4-Cyanobenzotrifluoride~Alpha,Alpha,Alpha-Trifluoro-P-Tolunitrile

4-Cyanotrifluorotoluene and α,α,α - trifluoro-p-toluonitrile, both contain trifluoromethyl and cyanyl groups, which are similar in structure and have many similarities in chemical properties.
Looking at its electronic effect, trifluoromethyl has strong electron-absorbing properties, which can reduce the density of aromatic ring electron clouds, make electrophilic substitution reactions more difficult, and can enhance molecular polarity. Cyanyl groups are also electron-withdrawing groups, and they work together to have a significant impact on the electron distribution of molecules. In chemical reactions, electron-withdrawing trifluoromethyl and cyanyl groups will reduce the density of aromatic ring adjacent para-electron clouds, and the meta-sites are relatively enriched. Electrophilic reagents are more inclined to attack the meta-sites.
Both have cyanyl groups, which can participate in many cyanyl-related reactions. For example, hydrolysis generates carboxyl groups. Under acidic or basic conditions, cyanyl groups can be gradually converted into amides, and then hydrolyzed into carboxylic acids. Another example is reduction reactions, where cyanyl groups can be reduced to amino groups or imines, which can be used to synthesize a variety of nitrogen-containing compounds.
At the same time, due to the presence of trifluoromethyl groups, the molecular stability and fat solubility of the two are enhanced. In the field of organic synthesis, it is often used as a key intermediate to construct complex fluorinated organic molecules. Due to its unique structure and properties, it is widely used in the fields of medicine, pesticides and materials science. In medicine, its unique electronic effects and stability can be used to design and synthesize specific biologically active drug molecules; in the field of pesticides, it is helpful to develop high-efficiency, low-toxicity and environmentally friendly pesticides; in materials science, materials can be endowed with special properties, such as corrosion resistance and optical properties.

4-Cyanobenzotrifluoride and α,α,α - trifluoro-p-toluenitrile have similar structures, but they show different application scenarios in common synthesis reactions due to subtle structural differences.
Let's talk about 4-cyanobenzotrifluoride first, because the cyano group and trifluoromethyl are based on the specific position of the benzene ring and have unique electronic effects. In the field of drug synthesis, it is often used as a key intermediate. For example, when creating a specific biologically active drug, its cyanyl group can be converted into carboxyl group, amide group, etc. through a series of reactions, and specific functional groups are introduced to fit the drug target. In the field of materials science, it participates in the preparation of fluoropolymers. Trifluoromethyl gives the material excellent weather resistance, chemical corrosion resistance and low surface energy characteristics, which can be used to make high-performance coatings and membrane materials.
In contrast α,α,α - trifluoro-p-toluenitrile, because methyl and trifluoromethyl coexist on one side of the benzene ring, the spatial hindrance and electron cloud distribution are different. It is widely used in the synthesis of pesticides, and has high biological activity and selectivity for specific pests. Trifluoromethyl enhances lipophilicity and promotes its penetration into the waxy layer on the surface of pests. In organic synthetic chemistry, it is an important building block for the construction of complex fluorine-containing compounds. Various functional groups are derived through nitrile reaction. Due to the suitable spatial structure, the stereoselectivity of compounds with special configurations is better, which is different from 4-cyanobenzotrifluoride.

4 - Cyanobenzotrifluoride and Alpha, Alpha, Alpha - Trifluoro - P - Tolunitrile are both fluorinated organic compounds, but their physical properties have many differences, as detailed below:
- ** Melting boiling point **: The melting boiling point of a substance is closely related to the intermolecular force. 4 - Cyanobenzotrifluoride molecule contains a cyanide group (-CN), which is very polar and can cause strong dipole-dipole interactions between molecules. At the same time, Alpha, Alpha, Alpha - Trifluoro - P - Tolunitrile also contains trifluoromethyl (-CF 🥰), but compared with 4 - Cyanobenzotrifluoride, the intermolecular force is relatively weak. Therefore, under normal circumstances, the melting point and boiling point of 4 - Cyanobenzotrifluoride will be higher than that of Alpha, Alpha, Alpha - Trifluoro - P - Tolunitrile. According to common sense, the melting point of 4 - Cyanobenzotrifluoride or around - 20 ° C, the boiling point is about 200 ° C; while the melting point of Alpha, Alpha, Alpha - Trifluoro - P - Tolunitrile or around - 40 ° C, the boiling point is about 180 ° C.
- ** Solubility **: The solubility often follows the principle of "similar miscibility". Both are organic compounds and have certain solubility in common organic solvents such as dichloromethane, chloroform, toluene, etc. However, due to the strong polarity of the cyanyl group, the solubility in polar organic solvents such as acetone and acetonitrile is better; Alpha, Alpha, Alpha - Trifluoro - P - Tolunitrile due to the presence of trifluoromethyl, the overall polarity of the molecule is slightly weaker, and the solubility in non-polar or weakly polar organic solvents such as n-hexane is relatively good.
- ** Other physical properties **: Both have a higher density than water, and have certain chemical stability and thermal stability due to the presence of fluorine atoms. However, 4-Cyanobenzotrifluoride cyanyl groups can participate in a variety of chemical reactions, such as hydrolysis to form carboxylic acids, addition reactions with nucleophiles, etc., which may affect some of their physical properties during the reaction process; Alpha, Alpha, Alpha - Trifluoro - P - Tolunitrile trifluoromethyl groups make molecules have unique electronic effects and spatial effects, affecting their physical properties and chemical reactivity.

4-Cyanobenzotrifluoride (4-Cyanobenzotrifluoride) and α,α,α - trifluoro-p-methylbenzonitrile (Alpha, Alpha, Alpha-Trifluoro-P-Tolunitrile) need to be compared in the market price. Many factors need to be considered in detail.
Both are important raw materials used in the field of organic chemistry. The fluctuation of its price depends first on the market supply and demand trend. If there is a lot of demand for 4-cyanobenzotrifluoride at some time, and the production is not enough, the price will rise; conversely, if the supply exceeds the demand, the price may drop. α,α,α - the same is true for trifluoro-p-methylbenzonitrile.
Furthermore, the difficulty of obtaining raw materials and the simplicity of the preparation process have a significant impact on the price. If the raw materials required for the preparation of 4-cyanobenzotrifluoride are rare and difficult to find, or the preparation method is complicated and time-consuming, the price is high; if α,α,α - the preparation of trifluoro-p-methylbenzonitrile is relatively simple and the raw materials are easy to cause, the price may be slightly lower.
In addition, the political and economic situation of the current situation is also the key. The degree of taxation and the barriers to trade can change the price. If a place imposes a heavy tax on the production and sales of 4-cyanobenzotrifluoride, its price will increase; if α,α,α - trifluoride-p-methyl benzonitrile is limited in international trade, it will also disturb its price.
However, with common sense, if the market supply and demand of the two are similar, the difficulty of preparation process is similar, and the political and economic environment is not very different, the price may not be far. However, the market situation is unpredictable, in order to know the exact price comparison, it is still necessary to observe the real-time market conditions, and consult the industry merchants and manufacturers to obtain accurate numbers.

4-Cyanobenzotrifluoride and α,α,α - trifluoro-p-toluenitrile are both organic chemicals, and there are many things that need to be paid special attention to during storage and transportation.
The first priority is safety, both of which are toxic and irritating. When storing, it should be placed in a cool and well-ventilated place, away from fire and heat sources, because it can cause fire, hot topic or combustion explosion. The temperature of the warehouse should be controlled within a specific range to prevent changes in the properties of substances due to excessive temperature. And it should be stored separately from oxidants, acids, bases, etc., to avoid dangerous chemical reactions caused by mixed storage.
Packaging must be tight, 4-cyanobenzotrifluoride and α,α,α - trifluoro-p-toluenonitrile are volatile or leaking, packaging materials should be resistant to chemical corrosion, good sealing, to prevent leakage caused by environmental pollution and personal injury. During transportation, ensure that the container does not leak, collapse, fall, or damage. The means of transportation need to have corresponding fire and emergency treatment equipment. In case of leakage, it can be dealt with in time.
Furthermore, it should be handled lightly to avoid impact, friction, and vibration to prevent package damage. Operators should wear appropriate protective equipment, such as gas masks, chemical protective clothing, protective gloves, etc., to prevent contact with such substances.
Storage areas and transport vehicles should also have clear warning signs indicating the danger of substances, so that relevant personnel can be vigilant. Daily inspections of the storage environment and transportation equipment are also required to check for leaks, packaging damage, etc., and problems are found and dealt with in a timely manner, so as to ensure the safety of 4-cyanobenzotrifluoride and α,α,α - trifluoro-p-toluenitrile during storage and transportation.