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What are the main uses of 4-Cyano-2-Fluorobenzotrifluoride?
4-Cyano-2-fluorotrifluorotoluene is an important compound in organic chemistry. It has a wide range of uses and is often a key intermediate in the synthesis of many effective drugs. The unique properties of cyano, fluorine atoms and trifluoromethyl in the molecular structure can endow the synthesized drugs with specific physiological activities and pharmacological properties, such as enhancing the binding force between drugs and targets, improving the stability of drug metabolism, etc., which helps to create high-efficiency therapeutic drugs for specific diseases, such as cancer and cardiovascular diseases.
In the field of materials science, 4-cyano-2-fluorotrifluorotoluene also plays an important role. It can be used to prepare polymer materials with special properties, which may endow the materials with excellent chemical stability, thermal stability and electrical properties due to their structural properties. For example, in electronic materials, the polymers synthesized with it can be used as high-performance insulating materials to meet the strict requirements of material stability and insulation in electronic devices; in the field of optical materials, the substances involved in the synthesis may have unique optical properties, suitable for optical coatings, photochromic materials, etc.
In addition, in pesticide chemistry, it is an important raw material for the synthesis of new pesticides. With its own structural characteristics, the synthesized pesticides may have high insecticidal, bactericidal or herbicidal activities, and are environmentally friendly, with low residues, which can effectively protect the growth of crops and reduce the negative impact on the ecological environment. Overall, 4-cyano-2-fluorotrifluorotoluene has indispensable uses in many important fields and is of great significance to promoting the development of related industries.
What are the physical properties of 4-Cyano-2-Fluorobenzotrifluoride?
4-Cyano-2-fluorotrifluorotoluene is an organic compound with unique physical properties. It is a colorless to light yellow liquid and is relatively stable at room temperature and pressure. Looking at its color and morphology, this compound has a specific characteristic due to its molecular structure due to the special group it contains. Colorless to light yellow liquid morphology is common in fluoro- and cyanoorganic compounds. Such compounds exhibit such color due to differences in atomic electronegativity and unique electron cloud distribution.
When it comes to volatility, 4-cyano-2-fluorotrifluorotoluene is volatile because of its limited intermolecular force. The fluorine atom in the molecule is highly electronegative and forms a strong polar bond with the carbon atom. The presence of trifluoromethyl further affects the intermolecular force, weakening its interaction, and causing some molecules to easily obtain enough energy to escape from the liquid surface at an appropriate temperature, showing volatility.
Besides solubility, this compound is slightly soluble in water, because water is a strong polar solvent, and although the 4-cyano-2-fluorotrifluorotoluene molecule contains polar groups cyanide and fluorine atoms, the overall molecular structure is not highly polar, and it is difficult to form strong interactions with water molecules, such as hydrogen bonds, so it is difficult to dissolve in water. However, it is easily soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc. These organic solvents can interact with the compound molecules through van der Waals forces to achieve good mutual solubility.
The boiling point and melting point of 4-cyano-2-fluorotrifluorotoluene are also affected by the molecular structure. The specific melting point varies depending on the precise measurement conditions, but in general, the melting point range is consistent with that of organic compounds containing similar groups. The cyanyl group in the molecule can participate in the formation of weak interactions between molecules, such as dipole-dipole interaction, which can increase the melting boiling point; while trifluoromethyl, due to its special electronic effects and spatial effects, will have complex effects on the intermolecular forces, and various factors determine its melting boiling point.
In addition, the density of this compound is relatively large. Due to the large mass of fluorine atoms in the molecule and the special electronic structure, coupled with the presence of cyanyl groups, the whole molecule has a relatively high mass-to-volume ratio, resulting in a density greater than that of common organic solvents. When storing and using 4-cyano-2-fluorotrifluorotoluene, it is necessary to handle it properly according to these physical properties to ensure safe and effective use.
Is 4-Cyano-2-Fluorobenzotrifluoride chemically stable?
4-Cyano-2-fluoro-trifluorotoluene, the stability of this material is related to multi-terminal. Its molecule contains cyanide (CN), fluorine atom (F) and trifluoromethyl (CF), and has a unique structure.
Cyanyl has high chemical activity and can participate in various reactions, such as hydrolysis to carboxyl groups and reaction with nucleophiles. However, under normal circumstances, if the environment does not have specific conditions to initiate the reaction, the cyanyl group is relatively stable. Although the fluorine atom has high electronegativity and large C-F bond energy, it makes the molecule locally stable, and has a great influence on the reaction activity and molecular polarity, which will change the check point and difficulty of the reaction. Trifluoromethyl has strong electron absorption, which can affect the charge distribution and reactivity of molecules, but its own structure is relatively stable.
Under general storage conditions, if there is no light, hot topic, strong acid or base or special catalyst, the chemical properties of 4-cyano-2-fluorotrifluorotoluene can be stable. However, in case of high temperature, the cyanyl group may decompose to produce toxic cyanide gas; in case of strong oxidants, or due to the influence of cyanyl group and trifluoromethyl group, oxidation reaction occurs; in case of active nucleophiles, cyanyl group is easy to react with it.
In summary, the chemical stability of 4-cyano-2-fluorotrifluorotoluene depends on the environmental conditions and the chemical substances it comes into contact with, and is not absolutely stable or unstable.
What is the production process of 4-Cyano-2-Fluorobenzotrifluoride?
The production process of 4-cyano-2-fluoro-trifluorotoluene is very delicate. The method starts at the beginning, or a suitable aromatic compound is taken as the base material, which must have a check point that can be converted into cyano and fluoro groups and connected to trifluoromethyl groups.
Prior to halogenation, a specific halogenating agent is used to introduce halogen atoms at a specific position on the aromatic ring under suitable reaction conditions. This step requires precise temperature control, timing control, and the amount of halogenating agent to ensure that the halogenation check point is just as expected and no side branches are generated.
Next, cyanation reaction is carried out. With a cyanide reagent, such as potassium cyanide or sodium cyanide, in a catalyst-assisted and appropriate solvent environment, the halogen atom is replaced by a cyanyl group. In this process, the choice of catalyst is crucial, related to the reaction rate and yield, and attention should be paid to the pH and stability of the reaction system to prevent side reactions such as cyanohydrolysis.
As for the fluorination step, fluorine-containing reagents are often used to replace hydrogen atoms at specific positions in a specific reaction medium. This step requires strict reaction conditions, and temperature, pressure, and reaction time need to be carefully controlled to obtain high-purity products.
Or there are other synthetic routes, such as the introduction of trifluoromethyl first, and then the cyanyl group and fluorine group. However, no matter what method, it needs to go through multiple steps of reaction. After each step, it must go through the order of purification to remove impurities and improve the purity of the product. The method of purification, or distillation, extraction, recrystallization, etc., should be followed according to the characteristics of the product and the nature of impurities. In summary, rigorous operation and fine control can obtain high-quality 4-cyano-2-fluorotrifluorotoluene products.
What is the price range of 4-Cyano-2-Fluorobenzotrifluoride in the market?
The price of 4-cyano-2-fluorotrifluorotoluene in the market is difficult to determine. Its price often changes due to many reasons, such as the supply and demand of the market, the process of production, the quality of quality, and the number of purchases, all of which can make its price fluctuate.
Looking at the past market conditions, when the purchase quantity is small, its price may be high. In terms of small quantities of reagent grade products, the price per gram may range from tens to hundreds of yuan. This is because reagent grade products are strict in purity and have high preparation costs, so the price is high.
If it is for industrial use, the purchase quantity is quite large, such as in kilograms or even tons, the price should be different. Due to the dilutive cost of mass production, the price per kilogram may be in the range of several hundred yuan. However, the market supply and demand are unstable, if there are many people in need and few people in supply, the price will also rise; on the contrary, if the supply exceeds the demand, the price may drop.
Furthermore, the preparation process and the price of raw materials also affect the price. New and excellent processes may reduce costs and make prices low; rising raw material prices will also cause their prices to rise. And different manufacturers produce, due to differences in quality, the price is also different. High quality or high price, while less expensive or cheap. The price of 4-cyano-2-fluorotrifluorotoluene fluctuates between tens of yuan per gram and hundreds of yuan per kilogram. The actual price depends on the current market conditions and specific trading conditions.