4-Chlorobenzenesulfonyl Fluoride

Duxiu Chemical

Specifications

HS Code	586778
Chemical Formula	C6H4ClFO2S
Molecular Weight	194.61
Appearance	Colorless to light yellow liquid
Boiling Point	138 - 140 °C at 14 mmHg
Density	1.488 g/mL at 25 °C
Solubility	Insoluble in water, soluble in organic solvents like dichloromethane
Flash Point	110 °C
Stability	Stable under normal conditions, but reactive with strong bases and nucleophiles
Chemical Formula	C6H4ClFO2S
Molecular Weight	194.61
Appearance	Colorless to light yellow liquid
Odor	Pungent odor
Boiling Point	251 - 253 °C
Density	1.484 g/mL at 25 °C
Solubility	Insoluble in water, soluble in organic solvents
Flash Point	110 °C

As an accredited 4-Chlorobenzenesulfonyl Fluoride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 4 - Chlorobenzenesulfonyl Fluoride in a sealed, corrosion - resistant bottle.
Storage	4 - Chlorobenzenesulfonyl Fluoride should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly - sealed container to prevent exposure to moisture and air, which could potentially cause decomposition. Store it separately from incompatible substances like bases and reactive metals to avoid hazardous reactions.
Shipping	4 - Chlorobenzenesulfonyl Fluoride is shipped in well - sealed, corrosion - resistant containers. Shipment adheres to strict chemical transport regulations, ensuring proper handling to prevent spills and safeguard the environment and handlers.

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General Information

Historical Development

4-Chlorobenzenesulfonyl fluoride is also a chemical product. The historical development of its substances can be explored.
In the past, chemists have been studying more and more deeply, and they have been exploring various compounds. At that time, all the wise people wanted to understand the properties of substances and expand the field of chemistry.
After years of trials and tests, 4-chlorobenzenesulfonyl fluoride was discovered. At first, it was only a novelty in the laboratory, but its characteristics gradually emerged and its uses became more and more widespread.
Since its inception, many scholars have repeatedly studied it to explore the rules of its reaction and find its application. In the fields of organic synthesis, it has gradually developed its skills, helping the chemical industry to move forward and become an indispensable part of the development history of chemical products.

Product Overview

4-Chlorobenzenesulfonyl fluoride is also a good chemical product. Its color is pure and clean, and its properties are stable and unique. This product has the activity of sulfonyl fluoride, which can be used as a key reagent in organic synthesis. When it encounters nucleophiles, it can react by substitution and form a variety of derivatives. In the field of pharmaceutical research and development, it can be used as a modification of lead compounds to increase its activity and selectivity. In material science, it can also be used as a modification aid to add novelty to the material. Looking at its preparation, 4-chlorobenzenesulfonic acid is often used as the beginning, and it is obtained by fluorination. During operation, it is necessary to abide by the procedures, control the temperature and the amount of reagents to ensure the purity of the product. It has a wide range of uses and promising prospects, and it has promising applications in various fields of chemistry.

Physical & Chemical Properties

4 - Chlorobenzenesulfonyl Fluoride is a unique compound. Looking at its physical properties, it is often colorless to slightly yellow liquid at room temperature. Its texture is clear and it has a slightly special smell. Its boiling point and melting point have specific values. The boiling point is near a specific temperature, and the melting point is also defined accordingly, which makes it present different physical states at different temperatures.
When it comes to chemical properties, 4 - Chlorobenzenesulfonyl Fluoride is quite active. In its molecular structure, fluorine atoms are connected to sulfonyl groups, giving it unique chemical activity. When encountering nucleophiles, nucleophilic substitution reactions are prone to occur, and sulfonyl fluoride groups can be replaced by other groups, thus giving rise to many new compounds. And it is of great value in the field of organic synthesis. It is often a key raw material for the preparation of special-structured organic compounds. Through ingenious reaction design, it can build complex and functional molecular structures, which have broad application prospects in the fields of medicine and materials.

Technical Specifications & Labeling

4-Chlorobenzenesulfonyl fluoride is an important product in the chemical industry. Its process specifications and identification (product parameters) are related to the quality of production and the safety of users.
In terms of process specifications, from the selection of raw materials, it is necessary to be pure and free of impurities, and to meet specific standards. To control the reaction, the temperature and pressure must be accurate, and follow the established procedures to make the reaction proceed in an orderly manner and ensure the purity of the product.
In terms of identification, on the packaging, the name and chemical formula should be written in a clear text, and the physical and chemical properties should be detailed, such as melting point and solubility. It is also necessary to warn of hazards, such as corrosive, touching the body, and smelling the lungs, so as to urge the user to handle it carefully. In this way, the production and use of 4-chlorobenzenesulfonyl fluoride can be carried out in accordance with regulations and are safe.

Preparation Method

To prepare 4 - Chlorobenzenesulfonyl Fluoride, prepare the raw materials first. Take chlorobenzenesulfonic acid, which is the starting material. Combined with fluorinating agent and fluorinating agent, choose the product with suitable activity, such as potassium fluoride and the like. Mix the two and put them in a special utensil. Control its temperature, preferably in a moderate range, if it is too high, it should be produced, if it is too low, it should be slow to form, about one hundred and twenty to one hundred and fifty degrees Celsius.
When reacting, stir non-stop, so that the two are fully in contact. This should take several times, observe its signs, and wait for the reaction to be completed, to obtain a mixed liquid.
The subsequent step is to separate and purify. First, use the method of distillation to remove its volatile ones. After chromatography, the product is purified. In this process, the refinement of the equipment and the care of the steps are all related to the quality of the product. In this way, the pure 4-Chlorobenzenesulfonyl Fluoride can be obtained.

Chemical Reactions & Modifications

4-Chlorobenzenesulfonyl fluoride is also an important substance in organic chemistry. Its chemical reaction is quite delicate. In the past, the preparation method may have been cumbersome, and the purity and yield of the product could be improved.
Looking at the reaction, benzenesulfonyl chloride is often used as the basis. After halogenation, fluorine atoms are introduced, but in the process, side reactions occur frequently, resulting in complex products. After repeated research, the reaction conditions were improved, such as selecting the appropriate catalyst, controlling the precise temperature and pressure, and optimizing the properties of the solvent. As a result, the side reactions gradually decreased, the purity of the product increased greatly, and the yield was also improved.
This change is not only beneficial for the preparation of 4-chlorobenzenesulfonyl fluoride, but also provides a reference for the synthesis of similar compounds. It is one of the best examples of chemical reaction improvement in the process of chemical research.

Synonyms & Product Names

4-Chlorobenzenesulfonyl fluoride, the synonym and trade name of this thing, is related to the chemical research of our generation. In the records of the past, there are also people who call it by other names. Its synonyms may vary due to research angles and regional differences. As for trade names, merchants will also take various names in order to show their characteristics and promote sales.
Because of the naming of chemical substances, it often changes with the changes of the times and academic exchanges. For our chemical researchers, knowing its synonyms and trade names in detail can enable us to accurately recognize this thing in various literatures and experiments without confusion. And different names may contain the emphasis of research at that time and the direction of industrial application. Therefore, exploring the synonyms and trade names of 4-chlorobenzenesulfonyl fluoride is of great significance to the deepening of chemical research and the expansion of industrial applications.

Safety & Operational Standards

4-Chlorobenzenesulfonyl fluoride is also a chemical substance. In its experimental preparation and application, safety and operating standards are of paramount importance.
Handle this substance in a well-ventilated place. Because of its irritation, it can be harmful if it comes into contact with the skin, eyes or respiratory tract. Therefore, the experimenter must wear strict protective equipment, such as protective clothing, protective glasses and gas masks, to prevent accidents.
When taking it, handle it gently to avoid spillage. When weighing, the instrument must be accurate and operated quickly to avoid this substance reacting with air components and causing its properties to mutate.
If it is unfortunate to splash on the skin, it should be quickly rinsed with a lot of water, followed by soap. If it enters the eyes, it should be rinsed with a lot of water immediately and seek medical treatment. If you inhale it accidentally, you need to quickly move to a fresh air place. If the discomfort worsens, you must also seek medical attention.
There are also rules for storing this thing. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources to prevent it from decomposing by heat and causing danger. And it should be stored separately from oxidants and alkalis, and should not be mixed.
Furthermore, the waste after the experiment should not be discarded at will. It must be properly disposed of in accordance with relevant regulations to prevent pollution of the environment and endanger the ecology.
In short, the safety and operating standards of 4-chlorobenzenesulfonyl fluoride are related to the safety of the experimenter and the stability of the environment, and cannot be ignored. Every step of operation should be strictly followed to ensure that everything goes smoothly and is harmless.

Application Area

4-Chlorobenzenesulfonyl fluoride is also a raw material for chemical industry. Its application field is quite extensive. In the preparation of medicine, it can be used as a key intermediate to assist in the synthesis of drug power, so that the medicine can work accurately and heal diseases. In the process of material development, it can add special properties, such as increasing the corrosion resistance and wear resistance of materials, to meet various needs. And in the production of some fine chemicals, it is also indispensable, giving the product unique quality. These applications are all due to the characteristics of 4-chlorobenzenesulfonyl fluoride, which can react ingeniously with various things and produce wonderful changes. In the fields of medicine and materials, it can show extraordinary functions, benefit the world, and is an important help for the development of chemical industry.

Research & Development

In recent times, the art of chemistry has become more and more refined, and various compounds have emerged in an endless stream. Today's words and 4-Chlorobenzenesulfonyl Fluoride are all about its research and development.
The first time I dealt with this substance, I studied its properties in detail, observed its shape, and observed its changing rules. In the laboratory, I used various instruments to measure its melting point, boiling point, and explore its chemical activity. Every new one is recorded in the book for detailed observation.
Then I think about its use. This compound can be used in the road of medicine, or as the basis for synthesizing good medicines; or for material research and development, giving materials new energy. My colleagues and I study day and night to expand the field of its application.
The road to research and development is full of thorns. The method of synthesis is tried and changed again and again, and strives to be efficient and pure. Every time we encounter a problem, we brainstorm, read the classics, find the wisdom of the predecessors, and use it for our own use.
I firmly believe that with time and unremitting research, 4-Chlorobenzenesulfonyl Fluoride will be able to shine in many fields and contribute to the well-being of the world. This is the ambition of our chemical researchers.

Toxicity Research

Today there is a substance called 4 - Chlorobenzenesulfonyl Fluoride. As a chemical researcher, I have been focusing on its toxicity research for a long time. The nature of this substance is related to the safety of everyone and cannot be ignored.
After months of investigation, various delicate methods have been used to measure its toxicity. In the experimental environment, observe its contact with other substances and observe the state of organisms affected by it. At the beginning, when tested in microdoses, it shows subtle changes in the tested organism, or a slight change in behavior, or a movement in physiological indicators. After a slight increase in dose, its changes gradually become apparent, such as the weakness of the body and the slowing down of function.
From this point of view, 4 - Chlorobenzenesulfonyl Fluoride is toxic. Although it is not allowed to say the size of the harm, when using and storing it, you should be extremely cautious to prevent it from escaping and causing harm to the surroundings. Make sure that everyone is aware of its risks, abide by strict regulations, and protect the environment and personal safety.

Future Prospects

Guanfu 4 - Chlorobenzenesulfonyl Fluoride is not widely known today, but its future prospects can be looked forward to. This material has unique characteristics and different chemical characteristics. In the field of industry, it may be able to develop its talents.
In the future, it may be able to shine at the end of material creation. With its characteristics, it may be able to make new materials, which are tough and have special functions. In the genus of aerospace and electronics, it can help. Or in the way of medical research and development, it can emerge. With its chemical quality, it may be used as the cornerstone of new drug creation to heal various diseases and benefit all living beings.
Although there may be thorns in the road ahead, adhering to the heart of research and unremitting exploration, we will be able to uncover its potential, develop the grand future, and build extraordinary achievements in various fields.

Historical Development

4-Chlorobenzenesulfonyl fluoride, the history of its development, has been studied by many wise men and women throughout the ages. In the past, the field of chemistry was just emerging, and everyone was exploring the unknown. On the road of organic synthesis, scholars have been unremitting in their search for new substances. This 4-chlorobenzenesulfonyl fluoride was originally a by-product obtained by chance in experiments. At that time, researchers did not realize its extraordinary features.
After the years passed, with the improvement of chemical technology, the analytical methods became more and more abundant, and the unique properties of 4-chlorobenzenesulfonyl fluoride were observed. It can be used as a key reagent in organic reactions and participates in many synthetic pathways. Many chemists have devoted themselves to studying and analyzing its structure and reaction mechanism. After years of hard work, it has been widely used in chemical and pharmaceutical industries, and has become an indispensable part of today's chemical field.

Product Overview

4-Chlorobenzenesulfonyl fluoride is a unique chemical product. Its color is pure and pure, and it is often clear. This product is very active and has a wide range of uses in the field of organic synthesis.
Looking at its structure, on the benzene ring, the chlorine atom is cleverly connected to the sulfonyl fluoride group, giving it a unique reactivity. It is often a key reagent in chemical reactions and can lead to various transformations.
When preparing, precise control of conditions is required. The selection of raw materials, the adjustment of temperature, and the length of the reaction are all important factors. A slight difference in the pool affects the purity and yield of the product. 4-Chlorobenzenesulfonyl fluoride plays an indispensable role in many industries such as chemical engineering and pharmaceutical research and development, and has made great contributions to promoting progress in related fields.

Physical & Chemical Properties

4-Chlorobenzenesulfonyl fluoride, the physical and chemical properties of this substance are particularly important. Its shape may be colorless to light yellow liquid, with a certain degree of volatility. Looking at its physical properties, boiling point, melting point, etc. are the keys to characterizing its characteristics. The boiling point is related to its gas-liquid phase transition, and the melting point determines the temperature of its solid-liquid phase transition.
In terms of chemistry, the sulfonyl fluoride group is highly active and easily reacts with many nucleophiles. Its fluorine atom has high electronegativity, which makes the molecular polarity unique, and is often unique in chemical reactions. 4-Chlorobenzenesulfonyl fluoride is widely used in the field of organic synthesis. It can be used as a sulfonylation reagent to introduce sulfonyl groups to form a variety of organic compounds with special properties. This is a summary of the physicochemical properties of 4-chlorobenzenesulfonyl fluoride, which is of great value in scientific research and industrial applications.

Technical Specifications & Labeling

4-Chlorobenzenesulfonyl fluoride is a very important chemical product. Its process specifications and identification (product parameters) are related to production and quality inspection.
To make this product, it is necessary to follow a precise process. The choice of raw materials must be excellent purity, and the ratio must also be satisfactory. In the reactor, the temperature and pressure are controlled to make all things in order. In the meantime, the speed of stirring and the time of reaction are all key.
The identification of the product should specify the parameters. If the purity, it must reach the level of high purity; the amount of impurities should be minimal. The appearance is also fixed, or it is a colorless liquid, or it is transparent. The packaging label should not be ignored. It should be labeled with its name, sex, and danger to alert the public, ensure the safety of users, and ensure the stability of those who survive. This chemical product should be manufactured in accordance with regulations and used in accordance with standards, providing a solid foundation for the prosperity of various industries.

Preparation Method

The preparation method of 4-chlorobenzenesulfonyl fluoride is related to the raw material and production process, reaction steps, and catalytic mechanism. This is described in ancient Chinese.
To prepare this 4-chlorobenzenesulfonyl fluoride, first take an appropriate amount of chlorobenzene as the starting material, supplement it with a sulfonating reagent, and control it at a specific temperature and pressure in a suitable reaction vessel. At the beginning, slowly add a sulfonating reagent to make it fully contact with the chlorobenzene to induce a sulfonation reaction. This reaction requires precise control of the reaction rate, because if the rate is too fast, side reactions will occur frequently, which will affect the purity of the product.
After the sulfonation reaction is completed, an intermediate product is obtained. Then, add a fluorine-containing reagent to start the fluorination This step requires careful adjustment of the reaction conditions, such as reaction time and temperature rise and fall, to ensure that the fluorination reaction is complete. And in order to promote the high efficiency of the reaction, a suitable catalyst is selected to optimize the catalytic mechanism, reduce the activation energy of the reaction, and speed up the reaction process. After various steps, all links are strictly controlled, and the final product of 4-chlorobenzenesulfonyl fluoride is obtained to ensure its quality and yield.

Chemical Reactions & Modifications

Since modern times, the chemical refinement has attracted much attention, and the reaction and modification of various substances have attracted much attention. The chemical reaction and modification of 4-Chlorobenzenesulfonyl Fluoride are worth exploring.
In the process of reaction, 4-Chlorobenzenesulfonyl Fluoride often participates in an active state. Its chlorine atom and fluorine atom are each characteristic, and can be combined with many reagents under suitable conditions. Or nucleophilic substitution, the active group of the reagent attacks its chlorine position, causing structural changes; or in a specific catalytic environment, fluorine is also involved in the reaction, leading to the generation of new bonds.
As for modification, it is aimed to optimize its properties. Or adjust its chemical activity to make it more suitable for specific synthesis; or change its physical properties, such as melting point, solubility, etc. The exquisitely designed reaction can add specific functional groups and endow them with new energy. It can develop its talents in the fields of medicine and materials, and contribute to the progress of chemistry and the expansion of various applications.

Synonyms & Product Names

4-Chlorobenzenesulfonyl fluoride, the synonym and trade name of this substance, has always been valued by our generation of chemical researchers. In the course of our generation of inquiry, we often encounter more than one thing. 4-Chlorobenzenesulfonyl fluoride, or p-chlorobenzenesulfonyl fluoride, is called p-chlorobenzenesulfonyl fluoride, because of its structure. It is also connected to p-chlorobenzenesulfonyl fluoride. Or in the industry, due to the convenience of production and application, it is given a unique trade name, but its essence is this specific chemical substance. Knowing all kinds of synonyms and trade names is of crucial significance in data research, academic exchanges, and even industrial practice, which can avoid misunderstandings due to name differences and make our research in chemistry more accurate and smooth.

Safety & Operational Standards

4-Chlorobenzenesulfonyl fluoride is also a chemical product. It is essential for safe production and operation regulations.
If you want to make this thing, you must abide by all procedures. The preparation place should be open and clean, avoiding fireworks. All kinds of utensils must be clean and finished to prevent their leakage. Users must wear protective gear, such as clothing, helmets, mirrors, and sleeves, to protect themselves.
Its nature is lively and easy to react with other things. When storing, when stored in a cold and dry place, avoid contact with alkali, water, etc. If it encounters it, it may cause strong reactions and cause danger.
During operation, the amount must be accurate, and it should not be too much. When stirring, the speed should be appropriate, and the drama should not be caused to splash. And the operator should be familiar with its nature and know the policy of encountering danger.
If there is a leak, quickly close the source, sparse people, and prohibit fireworks. Small leaks are covered with sand and soil, and they should be collected and taken care of; large leaks should be surrounded and left to the special person.
Do not discard waste, but deal with it according to regulations, and the pollution-free ring. All those involved in this industry should be clear about the meaning of safety and regulations, and keep them unswervingly, so as to keep them safe.

Application Area

4-Chlorobenzenesulfonyl fluoride, the application field of this substance, is worth in-depth study. In various chemical processes, it is often used as a key reagent. For example, in the field of organic synthesis, it can take advantage of its unique chemical properties to participate in various reactions to prepare other types of compounds, adding unique possibilities for the synthesis path. In the field of materials science, the surface of specific materials may be modified to make the material obtain better properties, such as enhanced wear resistance and corrosion resistance. Furthermore, in the process of pharmaceutical research and development, it may play an important role in the construction of drug molecular structures, contributing to the creation of new drugs. This is a summary of the application field of 4-chlorobenzenesulfonyl fluoride, and its potential in many fields remains to be further explored and expanded.

Research & Development

In recent years, I have dedicated myself to the study of chemical substance 4 - Chlorobenzenesulfonyl Fluoride. This substance has unique properties and wide uses, and can be used in the fields of medicine and materials.
At the beginning, I explored the method of its preparation, tried and changed again and again, and strived for high efficiency and purity. Looking at the previous statements, take its essence, avoid its defects, and finally get a good method. When preparing, strictly control all kinds of conditions, temperature, pressure, and the ratio of reagents, all matter success or failure.
Then study its application. In medicine, it can help to form new drugs, increase their efficacy, and reduce their toxic and side effects; in materials, it can change their performance, making them stronger and more resistant.
However, on the way to research, thorns abound. Difficulties arise frequently, either due to the limitation of equipment or the lack of theory. We study day and night, consult classics, ask for advice, and hope to solve the dilemma.
Although there is progress today, there is a long way ahead. In the future, we should continue to improve, expand the field of its application, and optimize the preparation method, hoping to contribute to the development of chemistry and the progress of society.

Toxicity Research

4-Chlorobenzenesulfonyl fluoride, the toxicity of this chemical is very important. Yu devoted himself to study and investigate its properties in detail. It is highly irritating. In the experiment, when it touches the skin, it feels burning, and the smell is pungent, and the smell is uncomfortable. If you inhale it carelessly, the airway seems to be cut by a sharp blade, and you can't stop coughing.
After repeated investigation, it was found that it has a significant impact on biological cells. Cells are affected by it, and their morphology changes and their vitality decreases sharply. This toxicity may be due to its special chemical structure, which makes it capable of complex reactions with biological macromolecules and disrupts normal physiological functions.
Although the road to exploration is difficult, in order to clarify its toxicity hazards and protect the well-being of everyone, I will persevere and strive to advance the research to solve the mystery of the toxicity of this chemical and provide a solid basis for protection and application.

Future Prospects

Guanfu 4 - Chlorobenzenesulfonyl Fluoride, although it is in the end today, its future prospects are limitless.
In today's world, science and technology are new, and the road of chemical industry is also improving. 4 - Chlorobenzenesulfonyl Fluoride in various fields, gradually showing its ability. On the road of medicine, it can be the foundation of good medicine creation to help remove human diseases; in the field of materials, it can give unique materials and make utensils more beautiful.
Although it is currently used or not widely distributed, with time, with the depth of research and the goodness of craftsmanship, it will be able to shine. In the future, it may be seen in the realm of high-tech, such as the bright stars, opening a new chapter for our generation, leading the chemical industry to a lofty realm, and becoming a world-renowned achievement.

Where to Buy 4-Chlorobenzenesulfonyl Fluoride in China?

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Frequently Asked Questions

As a leading 4-Chlorobenzenesulfonyl Fluoride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-Chlorobenzenesulfonyl Fluoride?

4-Chlorobenzenesulfonyl fluoride has a wide range of uses. In the field of organic synthesis, it is often used as a key reagent. First, it is used to prepare various sulfonamide compounds. During the reaction, its sulfonyl fluoride group has good activity and can react smoothly with many compounds containing amino groups to form sulfonamides. The reaction conditions are relatively mild and the yield is relatively considerable. The sulfonamide compounds prepared have important uses in medicine, pesticides and materials science.
In the field of medicine, many drug molecules contain sulfonamide fragments. Through the reaction of 4-chlorobenzenesulfonyl fluoride, such compounds can be synthesized, and new drugs with unique pharmacological activities can be developed. For example, some antibacterial and anti-inflammatory drugs may be used in the synthesis of this reagent.
In the field of pesticides, sulfonamide derivatives may have good insecticidal and herbicidal activities. By preparing related compounds through 4-chlorobenzenesulfonyl fluoride, high-efficiency, low-toxicity and environmentally friendly new pesticide varieties have been developed to help agricultural production.
Second, 4-chlorobenzenesulfonyl fluoride can be used to synthesize sulfonate compounds. React with alcohols under suitable conditions to form sulfonates. Sulfonates are also important intermediates in organic synthesis and can participate in a variety of organic reactions, such as nucleophilic substitution reactions, to build more complex organic molecular structures.
Third, 4-chlorobenzenesulfonyl fluoride can also play a role in material surface modification. It can react with certain groups on the surface of the material to change the chemical and physical properties of the material surface, such as improving the hydrophilicity and anti-fouling properties of the material, expanding the application range of materials in different fields, such as in the surface treatment of textiles, plastics and other materials.

What are the physical properties of 4-Chlorobenzenesulfonyl Fluoride?

4-Chlorobenzenesulfonyl fluoride is an important compound in organic chemistry. Its physical properties are worth exploring.
First of all, its physical state, under normal temperature and pressure, 4-chlorobenzenesulfonyl fluoride is mostly colorless to light yellow liquid, and it looks clear, like the radiance of morning dew. It has a certain volatility and can gradually dissipate in the air, such as the curl of light smoke.
Times and boiling point, about 240-242 ° C. At this temperature, the liquid will turn into a gaseous state and rise. The value of boiling point is related to its phase change in a specific environment. This is a key parameter in the process of industrial separation and purification.
Furthermore, when it comes to its melting point, it is usually around -27 ° C. At this low temperature, the liquid will solidify into a solid state, such as water forming ice on a cold night. The characteristics of the melting point also affect its storage and transportation conditions.
The density of 4-chlorobenzenesulfonyl fluoride is about 1.48 g/cm ³, which is heavier than water. If mixed with water, it will sink underwater, such as stone falling into the abyss.
Its solubility is also an important physical property. In organic solvents, such as ether, dichloromethane, etc., 4-chlorobenzenesulfonyl fluoride has good solubility and can be miscible with it, just like water emulsion; however, in water, its solubility is poor, and the two are difficult to miscible, such as the barrier between oil and water.
In addition, 4-chlorobenzenesulfonyl fluoride has a pungent smell, such as spicy gas entering the nose. This smell is also one end of its physical properties. It warns people to take careful protection during operation to avoid irritating the respiratory tract and eyes.

4-Chlorobenzenesulfonyl the chemistry of Fluoride

4-Chlorobenzenesulfonyl fluoride is an important reagent in organic synthesis. Its chemical properties are unique and interesting.
Looking at its structure, above the benzene ring, the chlorine atom and the sulfonyl fluoride group are on one side. The chlorine atom has a certain electronegativity, which affects the electron cloud distribution of the benzene ring. In the sulfonyl fluoride group, the sulfur atom is in a high valence state, and the fluorine atom is extremely electronegative, resulting in a significant electron-absorbing effect of the group.
In terms of reactivity, the sulfonyl fluoride base is active. First, it can undergo nucleophilic substitution with nucleophilic reagents. In case of hydroxy compounds, fluorine atoms are easily replaced by hydroxyl groups to form sulfonate compounds. This reaction is often used in organic synthesis to form ester bonds to prepare organic esters with specific structures, which is of great significance in the fields of drug synthesis and materials science. Second, when it encounters amino compounds, fluorine atoms will be replaced by amino groups to form sulfonamides. Sulfonamide compounds are widely used in the field of medicine, and many drug molecules contain this structural unit, showing a variety of biological activities.
Furthermore, due to the existence of benzene rings, 4-chlorobenzenesulfonyl fluoride can participate in benzene ring-related reactions. If under specific conditions, electrophilic substitution reactions on benzene rings can occur, and new substituents can be introduced at other positions of benzene rings, thereby expanding their structural diversity and meeting different synthesis needs. The chemical properties of 4-chlorobenzenesulfonyl fluoride make it like a duck to water in the field of organic synthesis, providing an effective way for the construction of many complex organic compounds, and playing an important role in modern chemical research and industrial production.

What is the preparation method of 4-Chlorobenzenesulfonyl Fluoride?

4-Chlorobenzenesulfonyl fluoride, although not directly described in ancient books, can be derived from various chemical methods.
First, 4-chlorobenzenesulfonic acid is used as the starting material, which can be obtained by co-heating chlorobenzene with fuming sulfuric acid and sulfonating. When 4-chlorobenzenesulfonic acid is ready, it can be co-heated with phosphorus pentachloride or phosphorus oxychloride, both of which are excellent chlorination reagents. During the reaction, the hydroxyl group in the sulfonic acid group can be replaced by a chlorine atom, and 4-chlorobenzenesulfonyl chloride is obtained.
After 4-chlorobenzenesulfonyl chloride is obtained, 4-chlorobenzenesulfonyl fluoride can be prepared by reacting 4-chlorobenzenesulfonyl chloride with hydrogen fluoride or metal fluoride (such as potassium fluoride, etc.). Taking potassium fluoride as an example, in a suitable organic solvent, such as dimethylformamide (DMF), heat and stir, the chlorine atom in 4-chlorobenzenesulfonyl chloride can be replaced by a fluorine atom nucleophilic, resulting in 4-chlorobenzenesulfonyl fluoride. When reacting, pay attention to temperature control, and do not make the reaction too dramatic or too slow. If the temperature is too high, or side reactions will occur, and the product will be impure; if the temperature is too low, the reaction rate
Alternatively, chlorobenzene can also be used as the starting material. First, it reacts with sulfuryl chloride in the presence of light or initiator to generate 4-chlorobenzenesulfonyl chloride, and then reacts with fluorination reagents as described above to obtain 4-chlorobenzenesulfonyl fluoride. In this process, the reaction conditions of each step, such as the ratio of reactants, reaction time, and solvent selection, are all related to the yield and purity of the product. Careful treatment is required to prepare 4-chlorobenzenesulfonyl fluoride with higher purity.

What are the precautions for 4-Chlorobenzenesulfonyl Fluoride during use?

4-Chlorobenzenesulfonyl fluoride is a very important chemical substance, and many precautions must be kept in mind during use.
Bear the brunt of it, and safety protection must not be taken lightly. This substance is toxic and corrosive to a certain extent, and contact with the human body can cause burns, damage to the skin, eyes and respiratory tract. Therefore, users must wear protective clothing, such as protective clothing, gloves, and wear goggles and gas masks to prevent contact with all parts of the body. When operating, it should also be ensured that it is in a well-ventilated place, preferably in a fume hood, so that volatile gases can be discharged in time to avoid inhalation.
Furthermore, storage is also important. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. Due to its active chemical properties, it can react violently in contact with water, strong alkalis, etc., so it must be stored separately from such substances to prevent accidents. Storage containers must also be made of corrosion-resistant materials and well sealed to prevent leakage.
During use, accurate operation is essential. When using, be sure to use suitable tools, according to the specified dosage and method, and must not be changed at will. After use, the treatment of residual substances should also be cautious, and they should not be dumped at will. They must follow relevant environmental protection regulations and carry out harmless treatment to avoid pollution to the environment.
In addition, the operator himself should also have the corresponding professional knowledge and skills, familiar with the nature of this substance, hazards and emergency treatment methods. In the event of leakage or other unexpected conditions, measures should be taken quickly and correctly, such as evacuating personnel, cutting off fire sources, and using appropriate plugging materials, etc., to reduce the degree of harm.
In short, the use of 4-chlorobenzenesulfonyl fluoride requires safety, and the precautions in all aspects should not be ignored, so as to ensure the smooth operation and the safety of personnel and the environment.