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4 What are the main uses of Chloro Benzo Trifluoride?
4-Chlorotrifluorotoluene, also known as p-chlorotrifluorotoluene, is a crucial raw material in organic synthesis and has a wide range of uses in many fields.
First, in the field of pharmaceutical synthesis, this compound has a wide range of uses. Due to its unique chemical structure, it can be used as a key intermediate for the synthesis of a variety of specific drugs. For example, in the preparation of some antibacterial drugs, 4-chlorotrifluorotoluene can be introduced through a series of chemical reactions to introduce specific functional groups, enhance the drug's ability to inhibit and kill bacteria, and improve drug efficacy.
Second, in the manufacture of pesticides, 4-chlorotrifluorotoluene also plays an indispensable role. With this as the starting material, a variety of high-efficiency pesticides can be prepared. These pesticides have excellent insecticidal and weeding properties, and have relatively little impact on the environment. For example, some fluorinated pesticides are based on them. With the special properties of fluorine atoms, they can enhance the binding force between pesticide molecules and receptors in target organisms, and improve the selectivity and activity of pesticides.
Furthermore, in the dye industry, 4-chlorotrifluorotoluene also has important applications. It can participate in the synthesis of dyes with special colors and properties. Due to its structure, the dye has unique stability and light resistance, making the dyed fabric bright and long-lasting, and is widely used in the textile printing and dyeing industry.
In addition, in the field of materials science, 4-chlorotrifluorotoluene also shows unique value. Through appropriate reactions, it can be introduced into polymer materials, giving the materials special physical and chemical properties, such as improving the material's heat resistance, chemical corrosion resistance, etc., providing an important raw material basis for the research and development and preparation of new materials.
In short, 4-chlorotrifluorotoluene, as a key organic raw material, plays an extremely important role in many fields such as medicine, pesticides, dyes and materials due to its unique chemical structure and properties, and promotes the continuous development and progress of various industries.
4 What are the physical properties of Chloro Benzo Trifluoride
4-Chlorotrifluorotoluene, its physical properties are as follows:
This substance is a colorless to slightly yellow transparent liquid at room temperature, and it looks clear and pure. Its smell is unique, irritating, and pungent. The boiling point is about 138-142 ° C. At this temperature, the liquid will rise into a gaseous state. The melting point is quite low, about -34 ° C. When the ambient temperature drops below this point, it condenses from a liquid state to a solid state.
Its density is greater than that of water, about 1.388-1.396g/cm ³. When placed in water, it will sink to the bottom. The solubility in water is extremely poor and almost insoluble. However, in many organic solvents, such as ethanol, ether, acetone, etc., it has good solubility and can be mutually soluble with it to form a uniform mixing system.
4-chlorotrifluorotoluene has a fixed vapor pressure at a specific temperature, and the vapor is heavier than air, which is easy to accumulate in low places. Its flash point is about 47 ° C. In case of open flames and hot topics, it is very easy to burn. When burning, it will produce toxic hydrogen chloride and fluorine-containing compound fumes, which are harmful to the environment and human body. Because of its physical properties, when storing and using, it is necessary to strictly abide by safety procedures to prevent accidents such as fire and poisoning.
4 What are the chemical properties of Chloro Benzo Trifluoride
4-Chlorotrifluorotoluene, also known as p-chlorotrifluorotoluene, is a key intermediate in organic synthesis. This substance is a colorless and transparent liquid with a special odor, insoluble in water, but miscible with most organic solvents.
From a chemical point of view, the molecule contains chlorine atoms and trifluoromethyl groups, giving it unique reactivity. Among them, chlorine atoms are affected by benzene rings and trifluoromethyl groups, and can undergo various substitution reactions. For example, in nucleophilic substitution reactions, chlorine atoms can be replaced by nucleophiles such as hydroxyl groups and amino groups. Like co-heating with sodium hydroxide solution under alkaline conditions, chlorine atoms may be replaced by hydroxyl groups to form p-hydroxytrifluorotoluene; if reacted with ammonia, p-aminotrifluorotoluene may be formed.
The presence of trifluoromethyl greatly enhances the electron-absorbing ability of the molecule and reduces the electron cloud density of the benzene ring. As a result, the electrophilic substitution reaction on the benzene ring is more difficult and the reaction conditions are more severe. For example, when nitrification is carried out, more severe conditions are usually required, and the main product is the meta-substitution. Due to the strong electron-absorbing effect of trifluoromethyl, the density of the ortho and para-electron clouds decreases more than the meta-position, so that the electrophilic reagents are more inclined to attack the meta-position.
In addition, 4-chlorotrifluorotoluene can also participate in many reactions such as halogenation and reduction. Under suitable catalyst and reaction conditions, more halogen atoms can be introduced into the benzene ring; or some groups in the molecule can be reduced and converted into other useful compounds. Its chemical properties are active, and it is widely used in many fields such as drug synthesis, pesticide research and development, and material science.
4 What is the production method of Chloro Benzo Trifluoride?
4-Chloro-trifluorotoluene, the preparation method has been known since ancient times. In the past, benzoyl chloride was often used as the starting material to prepare this agent, and it was obtained through many delicate steps.
First, benzoyl chloride and anhydrous aluminum chloride are co-placed in a special device. This device needs to be protected from water vapor to avoid the disturbance of impurities. When the two are heated, interchlorobenzoyl chloride is produced. This step requires strict temperature control. If the heat is high, the side should be clumped, and if the heat is low, it should be slow to form.
Then, m-chlorobenzoyl chloride is mixed with hydrogen fluoride, accompanied by a suitable catalyst. The force of the catalyst promotes its response speed, making chlorine easy to be fluorinated. When the time comes, observe its appearance, observe its temperature, and wait until it is finished to get 4-chloro-trifluorotoluene crude product.
However, the crude product is not pure and needs to be refined. By distillation, according to the difference of boiling, remove the impurities and keep the purity. The distillation device needs to be carefully selected, and the temperature and pressure also need to be carefully adjusted, so that high-purity 4-chloro-trifluorotoluene can be obtained.
There are also those who start with p-chlorotoluene. P-chlorotoluene first meets chlorine gas and responds to light to obtain p-chlorotoluene. Then hydrogen fluoride is used to replace chlorine, and 4-chloro-trifluorotoluene can also be obtained after multiple control. Its refining steps are similar to those of the previous method, requiring distillation to remove impurities in order to achieve high purity.
4 What are the precautions for Chloro Benzo Trifluoride in storage and transportation?
4-Chlorotrifluorotoluene is a chemical substance. When storing and transporting it, you must be careful and pay attention to many matters.
Let's talk about storage first. This substance should be placed in a cool and ventilated warehouse. Because of its certain volatility and chemical activity, high temperature or poor ventilation can easily cause danger. The temperature of the warehouse should not be too high to prevent its volatilization from intensifying or triggering chemical reactions. And it must be kept away from fire, heat sources, open flames and hot topics, which may trigger accidents. Furthermore, it should be stored separately from oxidizing agents and alkalis, and must not be mixed. Because of its chemical activity, it can be mixed with other substances or react violently, endangering safety. At the same time, the storage area should be equipped with suitable materials to contain leaks to prevent accidental leakage and make it difficult to clean up.
As for transportation, there are also many points. Transportation vehicles must ensure that the vehicle is in good condition, with complete safety facilities and emergency treatment equipment. During transportation, it is necessary to protect against exposure to the sun, rain, and avoid high temperature and humid environments. When loading and unloading, operators must wear appropriate protective equipment, pack and unload lightly, and must not be treated rudely to prevent packaging damage and material leakage. During transportation, relevant regulations and transportation routes must be strictly followed, and safe distances should not be changed at will, and safe distances should be maintained from densely populated areas, water sources, etc. All of these are to ensure the safety of 4-chlorotrifluorotoluene during storage and transportation, and no carelessness should be taken.