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What are the main uses of 4-Bromo-2-Iodobenzotrifluoride?
4-Bromo-2-iodotrifluorotoluene has a wide range of uses. In the field of organic synthesis, it can be called a crucial intermediate.
It can be used to create a wide variety of drugs. Due to the design and construction of drug molecules, specific functional groups and structural fragments are often introduced, and the functional groups of 4-bromo-2-iodotrifluorotoluene, such as bromine, iodine and trifluoromethyl, can be connected to other organic molecules through various chemical reactions to construct drug molecular structures with specific biological activities. For example, in the research and development process of some anti-tumor drugs, compounds with inhibitory effect on tumor cell growth can be synthesized from this starting material through multi-step reaction.
In the field of materials science, it also has good performance. It can be used to prepare polymer materials with special properties. Due to the existence of trifluoromethyl, it can endow materials with characteristics such as excellent corrosion resistance and low surface energy. By introducing 4-bromo-2-iodotrifluorotoluene into the polymer chain, high-performance materials can be prepared for applications in aerospace, electronic devices and other fields. For example, in the aerospace field, the application of such materials can improve the corrosion resistance of aircraft parts and prolong their service life.
In the field of pesticides, 4-bromo-2-iodotrifluorotoluene also plays an important role. It can be used as a key intermediate for the synthesis of new pesticides. With its unique chemical structure, the synthesized pesticides often have the advantages of high efficiency, low toxicity and environmental friendliness, which helps to improve the yield and quality of crops while reducing the negative impact on the environment. For example, the synthesis of certain pesticides can effectively kill pests and have low toxicity to non-target organisms.
What are 4-Bromo-2-Iodobenzotrifluoride synthesis methods?
The synthesis method of 4-bromo-2-iodotrifluorotoluene is described in many ancient books. One common one is to use compounds containing benzene rings as starting materials, and add bromine and iodine atoms by halogenation reaction. For example, suitable benzene derivatives can be taken first, and under specific reaction conditions, bromination is performed with brominating reagents. Among the brominating reagents, liquid bromine, N-bromosuccinimide, etc. can be selected. The reaction needs to be catalyzed by a suitable catalyst such as iron or iron salt, and carried out in a suitable solvent such as dichloromethane, etc., so that bromine atoms are introduced at specific positions in the benzene ring.
Next, the iodization reaction is carried out with an iodizing reagent. The iodizing reagent can be selected from potassium iodide, cuprous iodide, etc., with appropriate ligands and bases, in a specific organic solvent such as N, N-dimethylformamide, under heating and other conditions, the iodine atom is connected to the bromine atom at the ortho-position of the benzene ring, and then the structure of 4-bromo-2-iodine is constructed.
There is another way, starting with the phenyl series that already contains trifluoromethyl. The substance is first selectively halogenated. According to the positioning effect of the substituent on the benzene ring, the reaction conditions and halogenation reagents are cleverly selected to make the bromine and iodine atoms connect at the desired position. In this process, the precise regulation of reaction conditions is crucial, such as temperature, reaction time, and the ratio of reagent dosage, which all have a significant impact on the reaction process and the yield and purity of the product.
Another literature mentions that the coupling reaction catalyzed by transition metals is used to synthesize. Using bromine, iodine precursors and trifluoromethylation reagents as raw materials, under the action of transition metal catalysts such as palladium and nickel, with the help of ligands, in a suitable base and solvent system, the target molecular structure is constructed through coupling reaction. This approach can effectively avoid the accumulation of impurities in the multi-step reaction and improve the purity and yield of the product. However, this method requires strict reaction conditions and catalysts, and the cost is relatively high.
What are the physical properties of 4-Bromo-2-Iodobenzotrifluoride?
4-Bromo-2-iodotrifluorotoluene is an important compound in organic chemistry. Its physical properties are unique and related to the application and reaction characteristics of this compound.
First of all, under normal temperature and pressure, 4-bromo-2-iodotrifluorotoluene is mostly colorless to light yellow liquid, with clear texture and fluidity. This appearance characteristic can be used as a preliminary basis for identification in many chemical processes and laboratory operations.
As for the boiling point, it is about 190-200 ° C. The importance of boiling point lies in the separation and purification of substances. During distillation operation, controlling this boiling point range can effectively separate 4-bromo-2-iodotrifluorotoluene from the mixed system to obtain a pure product.
In terms of melting point, its melting point is low, roughly around -20 ° C. The low melting point keeps the compound in a liquid state at room temperature, which is convenient for various solution preparation and reaction operations. In a low temperature environment, it is necessary to pay attention to its solidification characteristics so as not to affect the relevant working process.
The density is about 2.1 - 2.3 g/cm ³, which is higher than that of common organic solvents. This density property is of great significance in separation processes such as liquid-liquid extraction, which can be used to achieve effective stratification and separation of this compound from other liquids by means of density differences.
Solubility is also a key physical property. 4-Bromo-2-iodotrifluorotoluene is insoluble in water because water is a polar molecule, and the polarity of this compound is weak. According to the principle of "similar compatibility", the two are incompatible. However, it is soluble in most organic solvents, such as dichloromethane, chloroform, toluene, etc. This solubility makes it convenient to select suitable solvents in organic synthesis reactions, build a reaction environment, and promote the smooth progress of the reaction.
The physical properties of 4-bromo-2-iodotrifluorotoluene, such as appearance, boiling point, melting point, density and solubility, play a decisive role in its application in organic synthesis, chemical production and analysis and testing. In-depth understanding of these properties can better control the compound.
What are the chemical properties of 4-Bromo-2-Iodobenzotrifluoride?
4-Bromo-2-iodine trifluorotoluene, an organic compound. Its chemical properties are unique and it plays an important role in many organic synthesis reactions.
In terms of its reactivity, the presence of bromine and iodine atoms in the molecule makes it highly reactive. Bromine and iodine are both halogen elements, and the presence of halogen atoms makes this compound prone to nucleophilic substitution. In the presence of suitable nucleophiles, bromine or iodine atoms can be replaced by nucleophiles. For example, if sodium alcohol is used as a nucleophilic reagent, under suitable conditions, bromine or iodine atoms can be replaced by alkoxy groups to form corresponding ether compounds. In this process, the nucleophilicity of nucleophiles, reaction temperature, solvent and other factors have a significant impact on the reaction process and product formation.
Furthermore, due to the strong electron absorption of trifluoromethyl, the electron cloud density distribution on the benzene ring will be affected. Trifluoromethyl reduces the electron cloud density of the benzene ring, making the electrophilic substitution reaction on the benzene ring relatively difficult. Compared with similar benzene series compounds without trifluoromethyl, the electrophilic substitution requires more severe reaction conditions, and the substitution position is also affected by the positioning effect of trifluoromethyl. Usually, electrophilic reagents tend to attack positions on the benzene ring that are far away from the trifluoromethyl and have relatively high electron cloud density.
In addition, the carbon-halogen bond in the molecule of 4-bromo-2-iodotrifluorotoluene can undergo a reduction reaction under certain reduction conditions, and the halogen atoms can be removed by reduction to form benzene derivatives without halogen atoms. However, this reduction reaction requires the selection of suitable reducing agents and reaction conditions to ensure the selectivity and efficiency of the reaction.
In summary, the chemical properties of 4-bromo-2-iodotrifluorotoluene are determined by the halogen atoms and trifluoromethyl atoms it contains. In the field of organic synthesis, its active reactivity provides various possibilities for the construction of various organic compounds.
What is the price range of 4-Bromo-2-Iodobenzotrifluoride in the market?
4-Bromo-2-iodotrifluorotoluene is on the market, and its price range is difficult to determine. The price of this product often changes for a variety of reasons.
First, the cost of production is the main factor. If the price of raw materials fluctuates, the price of 4-bromo-2-iodotrifluorotoluene will fluctuate. If the bromide, iodide and fluorine-containing raw materials required for preparation are required, the price may vary due to the amount of minerals, the difficulty of production process, and changes in market supply and demand, which in turn affects the cost and price of this product.
Second, the complexity of the preparation process is also related. If the process is complex, requires multiple steps, high conditions, and the yield is not high, the cost will rise and the price will follow. Fine synthesis operations, strict control of reaction conditions, and complicated purification processes can all increase the cost, making it high in the market.
Furthermore, the situation of market supply and demand is the key. If there are many people, and the supply is limited, the price will rise; if the supply exceeds the demand, the price will fall. If the demand for this product in the pharmaceutical, materials and other industries increases sharply, but the production supply is not sufficient, the price will rise; conversely, if there is excess capacity and the demand is low, the price will go down.
In addition, regional differences also affect the price. Different places have different prices due to differences in transportation costs, tax policies, and market competition. In places with convenient transportation and fierce market competition, the price may be relatively low; in remote places with small markets, the price may be high.
From the above, the market price of 4-bromo-2-iodotrifluorotoluene ranges from a few yuan to a few tens of yuan per gram, but this is only a rough estimate. The actual price depends on the specific time, place, and supply and demand conditions.