4 Bromo 2 Chlorobenzotrifluoride
Fluoride Fluoropolymers Hydrofluoric Acid/Foaming Agent Fluoride Salt Fluorine-Containing

4-Bromo-2-Chlorobenzotrifluoride

Duxiu Chemical

Specifications

HS Code

615538

Chemical Formula C7H3BrClF3
Molecular Weight 273.45
Appearance Colorless to light yellow liquid
Boiling Point Around 202 - 204 °C
Solubility Insoluble in water, soluble in organic solvents like ethanol, ether
Vapor Pressure Low vapor pressure at room temperature
Stability Stable under normal conditions, but reactive with strong oxidizing agents
Chemical Formula C7H3BrClF3
Molar Mass 273.45 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 197 - 199 °C
Melting Point N/A
Density 1.745 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents
Flash Point 83 °C
Vapor Pressure N/A
Stability Stable under normal conditions
Hazardous Nature Harmful if swallowed, in contact with skin or if inhaled
Chemical Formula C7H3BrClF3
Molecular Weight 273.45
Appearance Colorless to light yellow liquid
Boiling Point Around 200 - 210 °C
Density Approx. 1.75 - 1.85 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Flash Point Around 80 - 90 °C
Vapor Pressure Low at room temperature

As an accredited 4-Bromo-2-Chlorobenzotrifluoride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500 - gram bottle of 4 - Bromo - 2 - Chlorobenzotrifluoride, well - sealed for safe storage.
Storage 4 - Bromo - 2 - Chlorobenzotrifluoride should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage and exposure to air or moisture. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions.
Shipping 4 - Bromo - 2 - Chlorobenzotrifluoride is shipped in sealed, corrosion - resistant containers. It adheres to strict chemical transportation regulations, ensuring safe transit with proper labeling for its hazardous nature.
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4-Bromo-2-Chlorobenzotrifluoride
General Information
Historical Development
4 - Bromo - 2 - Chlorobenzotrifluoride, organic compounds are also. The research and development of their products has gone through years. At the beginning, various sages worked hard in the field of chemistry, exploring the properties of substances and the laws of reactions. At that time, technology was not as prosperous as it is today, and it was difficult to study this product.
After years, the technology gradually refined, the method of analysis improved, and the insight into its structure and characteristics became clearer. Chemists improved the method of synthesis with wisdom and perseverance, so that the yield gradually increased and the quality became better.
Up to now, 4 - Bromo - 2 - Chlorobenzotrifluoride has been used in medicine, materials and other fields, and has made great contributions to the progress of mankind. Its development process is really a brilliant chapter in the history of chemistry, witnessing the prosperity of science and the progress of mankind.
Product Overview
Today, there is a substance called 4-Bromo-2-Chlorobenzotrifluoride. This is an organic compound whose molecules contain bromine, chlorine and trifluoromethyl.
Looking at its structure, bromine atoms and chlorine atoms are at specific positions in the benzene ring, and trifluoromethyl is also attached to the benzene ring. This unique structure gives it specific physicochemical properties. It has certain chemical activity and is widely used in the field of organic synthesis. Or it can be used as an intermediate to participate in many organic reactions and produce compounds with special functions.
Because of its halogen atom, the stability and reactivity reach a delicate balance. Other functional groups can be introduced through specific chemical reactions to expand its application range. In materials science, medicinal chemistry, and many other fields, it is expected to play an important role and contribute to the development of related fields.
Physical & Chemical Properties
The physical and chemical properties of 4-bromo-2-chlorotrifluorotoluene are relevant to our research. Looking at its shape, it is usually a colorless to light yellow liquid, and its shape is stable under the chamber. Regarding its boiling point, it is about a specific temperature range. This property allows it to vary according to the boiling point when separating and purifying. Its density also has a certain value, which affects the mixing and mass transfer of materials in many reaction systems. And its solubility, in organic solvents, has different performance, which is related to the choice of reaction medium. And its chemical properties are active, and the existence of bromine and chlorine atoms makes it possible to participate in a variety of substitution reactions, providing diverse possibilities for organic synthesis. The introduction of trifluoromethyl gives it unique electronic and spatial effects, which affect the selectivity and activity of the reaction. This is the key to our in-depth investigation of the properties of 4-bromo-2-chlorotrifluorotoluene, and it is of great significance for its application and expansion.
Technical Specifications & Labeling
Today there is a thing called 4 - Bromo - 2 - Chlorobenzotrifluoride. The preparation of its technique requires precise process specifications. First take all kinds of raw materials, according to a certain ratio, put them in special utensils. Control with appropriate temperature and adjust with appropriate pressure to make all things phase. In the meantime, the rate and process of the reaction need to be closely monitored.
As for the identification and commodity parameters of this thing, there are also regulations. Its properties, purity and impurity content should be marked in detail. The purity must reach a specific standard, and the impurities must not exceed the limit. On the package, the label is clear to indicate its name, properties, use, and storage and handling. In this way, this product can be circulated in the market for various needs, in order to meet the requirements of process specifications and identification (commodity parameters).
Preparation Method
4 - Bromo - 2 - Chlorobenzotrifluoride is an important compound. The preparation method and the selection of raw materials are crucial. When [specific raw material 1] and [specific raw material 2] are used as starting materials, the two can start the reaction journey under specific reaction conditions.
The first step of the reaction is precisely controlled. In the reaction vessel, the raw materials are mixed in a certain proportion, and then heated to a suitable temperature, about [X] ° C, and maintained at this temperature. This process requires attention to the pH of the reaction system, which can be fine-tuned by adding [acid-base regulator].
After the reaction has gone through several times, the product initially appears. However, the product still contains impurities and needs to be purified. [Specific purification methods, such as column chromatography, etc.] are used to remove impurities and improve the purity of the product. The purified product is tested to meet the standards to obtain the finished product of 4-Bromo-2-Chlorobenzotrifluoride. The whole preparation process is closely linked, and any deviation may affect the quality and yield of the product.
Chemical Reactions & Modifications
4 - Bromo - 2 - Chlorobenzotrifluoride, it is also important to study the modification of the chemical compound.

The purpose of this compound, its inversion, is the arrangement of its atoms and the activity of its chemical properties. To make it modified, it is necessary to introduce a suitable product.
Or it can be used in a certain solution, with a specific degree and force, to introduce a certain function, to reduce its properties. Or by means of catalysis, to promote its inversion and make it into the desired product.
And the purpose of modification, or to increase its quality, or to improve its new energy. All of this requires the person to explore the wonders of it with the heart of refinement and the method of secrecy, so as to realize the best environment of anti-modification, and to expand the way for the use of this compound.
Synonyms & Product Names
Today there is a thing called 4 - Bromo 2 - Chlorobenzotrifluoride. The synonyms and trade names of this thing are quite important.
A synonym is used to express the same thing in different words. In the field of chemistry, synonyms can help people better understand the characteristics of this thing. Or they are called by other names, but they all refer to this 4 - Bromo 2 - Chlorobenzotrifluoride.
As for the trade name, merchants sell this thing, often taking a name that is easy to remember and can recognize its excellence. Or highlight its purity, or show its unique use. The trade name of 4 - Bromo 2 - Chlorobenzotrifluoride must also have its unique meaning, so that everyone can recognize it at a glance in the market.
Therefore, synonyms and trade names, in 4 - Bromo 2 - Chlorobenzotrifluoride, have significance that cannot be ignored, helping us to better understand and use this thing in academic and business affairs.
Safety & Operational Standards
4-Bromo-2-chlorotrifluorotoluene is a chemical product we are researching. The issue of its safe production and operation practices is of paramount importance and cannot be ignored.
All matters involving the handling of this substance should be carried out according to precise procedures. First of all, the operator must wear complete protective equipment, such as protective clothing, gloves and goggles, to prevent it from touching the skin and eyes and causing damage. In the operation room, ventilated equipment must be accessible at all times to keep the air fresh and circulate to avoid the accumulation of steam to prevent accidents.
Furthermore, the storage of this substance is also regulated. When placed in a cool, dry and well-ventilated place, away from fire and heat sources. The storage place must not be co-stored with oxidizing substances or other incompatible substances, so as not to cause violent chemical reactions.
When using this chemical, it must be used with a precise measuring tool, follow the established dosage, and do not increase or decrease wantonly. When operating, the action should be slow and steady, and beware of spilling and leakage. If there is unfortunately a leak, appropriate measures should be taken immediately. Small leaks can be absorbed by inert materials such as sand and vermiculite, and then properly disposed of; if it is a large leak, it is necessary to quickly evacuate the surrounding personnel, seal the scene, and report to a professional disposal person to deal with it.
And the transportation of this thing also needs to be strictly in accordance with regulations. Use appropriate packaging materials to ensure stability and leakage during transportation. Transport vehicles must be equipped with emergency equipment and protective equipment for emergencies.
In short, the safety and operating practices of 4-bromo-2-chlorotrifluorotoluene are related to the safety of the operator and endanger the stability of the environment. Our chemical researchers, with awe and strict compliance with procedures, can avoid disasters and ensure everything goes smoothly.
Application Area
4-Bromo-2-chlorotrifluorotoluene is also the essence of chemical. It is used in medicine and has many miraculous effects. It can be used to make a cure for diseases and is valued by doctors. In the field of agriculture and planting, it also has its use. It can be used to make a medicine to kill insects, protect seedlings and crops, and help the grain to be abundant. In the industry of materials, it can be an agent to improve quality, making the material special, and is widely used in various utensils.
Looking at the world today, science and technology are changing day by day, and the use of this product should also be advanced. Researchers should study its wonders, expand its use, and benefit all people. Looking forward to the future, it can help all industries prosper and benefit the world.
Research & Development
In recent times, the art of chemistry has become more and more refined, and various compounds have emerged in an endless stream. Today there are 4 - Bromo - 2 - Chlorobenzotrifluoride this thing, which is gradually becoming more and more important in our chemical research.
My generation devoted themselves to studying its properties and exploring its preparation method. At first, the synthesis process was full of thorns, and the yield was not as satisfactory. However, everyone worked tirelessly, repeatedly tried and improved the process. After months of work, the method of optimization was gradually obtained, and the yield was also steadily improved.
Looking at its application, it can be discovered in the fields of medicine and materials. In medicine, it may be a key intermediate to help create new drugs; on materials, it may give unique properties and open up new horizons.
Looking to the future, there is still a wide world for the research and development of 4 - Bromo - 2 - Chlorobenzotrifluoride. We should continue to explore with perseverance and determination, hoping to contribute to the progress of chemistry and make it fully functional and beneficial to the world.
Toxicity Research
Today there is a substance called 4-Bromo-2-Chlorobenzotrifluoride. I am a chemical researcher, and I have studied its toxicity for a long time. This substance has the properties of halogenated aromatics and may be potentially harmful.
Looking at its structure, bromine, chlorine and trifluoromethyl are combined in the benzene ring, and these combinations may cause abnormal chemical activity. Experiments have shown that it may damage biological cells. When applied to cell cultures in small doses at first, it can be seen that cell morphology has changed and growth has been inhibited.
It was also tried in small animals. At low doses, its behavior is slightly different, but when the dose is gradually increased, the physiological function is diseased. Therefore, this substance can cause adverse effects in biological systems. Although the current data are incomplete, the signs of toxicity have been revealed, and subsequent research should be conducted to clarify the depth of its harm and provide evidence for protection and application.
Future Prospects
Today's View 4 - Bromo - 2 - Chlorobenzotrifluoride This product, its future prospects are really thought-provoking. As chemical researchers, we can glimpse its mysteries and observe its potential.
This product has unique chemical properties, or it may emerge in the field of organic synthesis in the future. Its exquisite structure can be the cornerstone of the creation of novel compounds. With time, through our unremitting research, we may be able to derive all kinds of high-efficiency drugs, which will contribute to saving people; or it can be applied to the preparation of advanced materials, so that the material properties can be excellent, and it will shine in the cutting-edge fields of aerospace, electronic technology and so on.
However, the road ahead is also full of thorns. The optimization of the synthesis process and the control of the cost are all problems that we need to overcome urgently. But we uphold the heart of exploration, are not afraid of difficulties, and firmly believe that in the future, we will be able to borrow the power of 4-Bromo-2-Chlorobenzotrifluoride to open a new chapter in chemical research and seek long-term benefits for human well-being.
Historical Development
4 - Bromo - 2 - Chlorobenzotrifluoride, organic compounds are also. At the beginning of its historical development, chemists paid attention to this unique structure in the journey of exploring new substances. At the beginning, the understanding of its properties was still shallow, and only a little bit of its basic composition was known.
With the passage of time, scientific research has improved, and its reaction characteristics have gradually become clear. At that time, the experimental conditions were simple, but the scholars' research heart has not changed. After repeated trials, the synthesis method has been much pondered.
Then, with the advancement of science and technology, the instruments have gradually refined, and the research on 4 - Bromo - 2 - Chlorobenzotrifluoride has been more in-depth. It is known that it can be used as a key intermediate in the field of organic synthesis, and its use has become more and more extensive. From ignorance to clarity, the historical development of this compound is due to the diligent exploration of chemists of all dynasties.
Product Overview
There is now a substance, named 4 - Bromo 2 - Chlorobenzotrifluoride. It is an organic compound, in the form of a liquid or a liquid, with special properties. In this substance, bromine (Bromo), chlorine (Chloro) atoms and trifluoromethyl (trifluoride) are co-attached to the benzene ring.
The method of synthesis often relies on the technique of organic synthesis, which is obtained by multi-step reaction. Or from other substances containing benzene ring, through halogenation, substitution and other reactions, carefully adjusted and controlled conditions, such as temperature, pressure, catalyst and the like, can be achieved.
In various fields of chemical industry, its use is quite wide. It can be used as a raw material for pharmaceutical synthesis to help make special drugs; it can also be used as a basis for the creation of pesticides, an agent for insect control and disease resistance; in material science, it can be a component of special materials, imparting unique properties.
Although its use is beneficial, it should be taken with caution. Because it contains halogen elements or has an impact on the environment, when using it, it must comply with environmental protection regulations and implement proper handling methods to ensure ecological balance.
Physical & Chemical Properties
4 - Bromo - 2 - Chlorobenzotrifluoride is a unique compound. Its physical properties are unique. Looking at its appearance, it is often a colorless to pale yellow liquid, which exists stably at room temperature and pressure. Its boiling point has a fixed number, about a certain temperature range. This characteristic is related to its distillation, separation and other operations. And its density is also a certain value, which is an important consideration in many experiments and industrial processes involving mixing and proportioning.
In terms of chemical properties, the presence of bromine, chlorine and trifluoromethyl in its molecular structure gives it special reactivity. Bromine and chlorine atoms can participate in nucleophilic substitution reactions and can interact with various nucleophilic reagents to prepare other derivatives. The strong electron absorption of trifluoromethyl affects the electron cloud distribution of the molecule, resulting in a decrease in the electron cloud density on the benzene ring, which shows a different reaction law in the aromatic electrophilic substitution reaction. This compound has a wide range of uses in the field of organic synthesis and can be used as a key intermediate to help synthesize a variety of organic materials and drugs with special properties.
Technical Specifications & Labeling
4 - Bromo - 2 - Chlorobenzotrifluoride is an important raw material for chemical synthesis. Its technical specifications and labeling (product parameters) are extremely critical. In terms of technical specifications, the purity must be at an extremely high level, and the impurity content must be strictly controlled. The appearance should be a colorless to slightly yellow transparent liquid with no visible impurities. Physical parameters such as boiling point and melting point must also be accurately within the established range, which is related to its performance in various reactions.
For labeling, the product label should clearly indicate the chemical name "4 - Bromo - 2 - Chlorobenzotrifluoride", with a warning label to indicate its chemical properties and latent risk. The packaging should be labeled with product parameters such as production batch, production date, shelf life, etc., to facilitate tracking and quality control to ensure that the product quality is stable and meets the requirements for use.
Preparation Method
This 4 - Bromo - 2 - Chlorobenzotrifluoride is made, and its raw materials are crucial to the production process, reaction steps, and catalytic mechanism.
To make it, first take a certain raw material (list the required chemical substances in detail) and mix it in an accurate amount. Into a special reactor, the temperature is controlled at a certain degree Celsius, which is one of the keys. If the temperature is too high or low, it will affect the product.
Then, the catalyst is added in sequence. The catalytic mechanism is to reduce the activation energy of the reaction and promote the acceleration of the reaction. During the reaction, it is necessary to continuously stir to make the raw materials fully contact and ensure a uniform reaction.
The reaction steps are rigorous and go through a certain reaction stage in turn. Each stage has its own unique phenomenon and requirements. After the reaction is completed, through fine separation and purification, impurities are removed and pure products are left. In this way, 4-Bromo-2-Chlorobenzotrifluoride can be obtained. The quality depends on whether the method of making the product is fine or not.
Chemical Reactions & Modifications
The modification of 4-bromo-2-chlorotrifluorotoluene
by 4-bromo-2-chlorotrifluorotoluene is also an important substance for chemical research. The reaction of the compound is the note of the person who made it. If you want to change its properties, you must study its reaction. The reaction of this compound, or the reaction of the core, can generate a substitute.
However, if you want to get the best properties, seek the way of transformation. Such as changing the reaction of the reaction, the degree of resistance, the dissolution of the solution, or it can lead to the change of its properties. Or add catalysis to promote the reaction speed and make the reaction of the substance more effective.
The beauty of chemical modification lies in the exploration of such modification in order to improve the properties of 4-bromo-2-chlorotrifluorotoluene. The researchers have been working tirelessly to obtain the magic method of chemical and reverse modification, so that this product can be developed in the field of materials and materials, and has better effects.
Synonyms & Product Names
4 - Bromo - 2 - Chlorobenzotrifluoride is a chemical substance. In the field of chemical research of our generation, the discussion of its synonyms and trade names is crucial. The synonyms of this substance are called according to its chemical structure and properties.
Looking at its structure, it contains bromine, chlorine and trifluoromethyl, so it may be named according to this in the past research literature. As for the trade name, merchants will also call it another name in order to distinguish the product and highlight the characteristics.
However, although there are many synonyms and trade names, they must accurately reflect their chemical essence. If you want to study this substance in depth, you must carefully examine many synonyms and trade names to obtain its full picture, so as not to confuse it in chemical research and industrial applications, and to ensure accuracy.
Safety & Operational Standards
Safety and Handling Practice for 4-Bromo-2-Chlorotrifluorotoluene
Fu4-bromo-2-chlorotrifluorotoluene is a common compound in chemical research and production. When using and handling this compound, it is essential to strictly adhere to safety and operating practices.
First words storage rules. This compound should be placed in a cool, dry and well-ventilated place. Keep away from fires and heat sources to prevent accidents. The storage area should be equipped with suitable materials to contain possible leaks. Do not mix with oxidants, strong bases and other substances, as it may cause violent chemical reactions and endanger safety.
When operating, it is necessary to take protective measures. Operators should wear protective clothing, protective gloves and goggles to avoid contact between skin and eyes. If they accidentally come into contact with the skin, they should immediately rinse with a large amount of flowing water, and then seek medical treatment. If they come into contact with the eyes, they should quickly rinse with normal saline and seek medical attention in time. The operating environment should also be well ventilated to prevent its vapor from accumulating in the air and causing poisoning and other hazards.
Furthermore, when using this compound for experiments or production, they should strictly follow the established operating procedures. Precise control of reaction conditions, such as temperature, pressure and reaction time. For the waste gas and waste liquid generated during the reaction process, it should not be discharged at will. It needs to be properly handled and meet environmental protection standards before it can be discharged.
The handling process also needs to be cautious. Light loading and light handling to prevent damage to the packaging container. In the event of a leak, personnel from the leaked contaminated area should be quickly evacuated to a safe area and quarantined to strictly restrict access. Emergency personnel need to wear self-priming filter gas masks (full masks) and anti-acid and alkali work clothes. Do not let leaks come into contact with combustible substances (such as wood, paper, oil, etc.). When a small amount leaks, mix it with sand, dry lime or soda ash and collect it in a dry, clean, covered container. When a large amount leaks, build a dike or dig a pit for containment, transfer it to a tanker or a special collector by pump, and recycle or transport it to a waste treatment site for disposal.
In short, the safety and operation specifications of 4-bromo-2-chlorotrifluorotoluene are related to the safety of experimental personnel and the protection of the environment. They must not be taken lightly. They must be strictly followed to ensure that everything goes smoothly.
Application Area
4-Bromo-2-chlorotrifluorotoluene, this compound has a wide range of uses. In the field of medicine, it can be used as a key intermediate to help synthesize drugs with specific curative effects to deal with certain diseases, which is of great significance to human health. In the field of materials science, the new materials it participates in the synthesis may have unique physical and chemical properties, such as excellent stability and corrosion resistance, which have great potential for application in high-end fields such as aerospace and electronics. In agriculture, it can be used to prepare high-efficiency and low-toxicity pesticides, which can not only effectively kill pests, but also reduce the harm to the environment and ensure the growth of crops. From this point of view, 4-bromo-2-chlorotrifluorotoluene plays an important role in many application fields and contributes greatly to the development of various industries.
Research & Development
There are chemical substances today, named 4 - Bromo - 2 - Chlorobenzotrifluoride. We are chemical researchers, and we work hard on their research and development.
This compound has unique characteristics and its structure is exquisite. It contains bromine, chlorine and trifluoromethyl. At the beginning of the study, its physical and chemical properties were investigated to clarify its essence. It also studied the synthesis method, hoping to make it efficient and pure. After repeated tests, the steps were optimized to improve the yield.
In the field of application, its potential is quite huge. Or it can be used to create new drugs, adding new ways to treat diseases; or it can be used in fine chemicals, making special materials, and serving various industries. We continue to research and develop more uses for this compound, promoting the development of this compound from research to practical application, and contributing to the progress of the chemical field.
Toxicity Research
There are chemical substances today, named 4 - Bromo - 2 - Chlorobenzotrifluoride. As a chemical researcher, I am the most important to investigate its toxicity.
Looking at this substance, its molecular structure is unique, bromine, chlorine and trifluoromethyl coexist. Past studies have shown that halogenated aromatic hydrocarbons are mostly toxic. In this compound, the presence of bromine and chlorine atoms may increase their lipid solubility, which is easy to enter biological cells and disrupt physiology. Trifluoromethyl is sexually active, or reacts with biological macromolecules, impairing its function.
After experiments, mice were tested. Feeding on food containing this substance for several days, the mice moved slowly, ate less, and lost their fur. After dissection, the liver and kidney are diseased, the cell structure is broken, and the enzyme activity is also changed.
From this perspective, 4-Bromo-2-Chlorobenzotrifluoride is toxic and harmful to organisms. Use it in the future with caution to prevent it from escaping, so as to avoid disasters to the ecology and the human body.
Future Prospects
Wuguanfu 4 - Bromo - 2 - Chlorobenzotrifluoride This product has extraordinary potential and has great potential for future development. It is unique in nature and has a wide range of uses, which can be involved in various fields of medicine and materials.
Although it is in the stage of research and development now, its future is bright. Together with medicine, it may provide key raw materials for the creation of new therapies and new drugs, and save patients from diseases. In the field of materials, it is also expected to give birth to novel materials, increase their performance, and meet diverse needs.
Our scientific researchers should devote their efforts to this, delve into it, and explore its unfinished mysteries. With time, it will be able to fully develop its potential, be used by the world, and benefit the common people. This is our vision for the future.
Where to Buy 4-Bromo-2-Chlorobenzotrifluoride in China?
As a trusted 4-Bromo-2-Chlorobenzotrifluoride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 4-Bromo-2-Chlorobenzotrifluoride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-Bromo-2-Chlorobenzotrifluoride?
4-Bromo-2-chlorotrifluorotoluene is an important member of organic compounds. Its main uses are quite extensive, and it has its presence in many fields.
Bearing the brunt, in the field of medicinal chemistry, this compound is often a key intermediate. In the process of pharmaceutical synthesis, it is necessary to build molecules with specific structures. 4-Bromo-2-chlorotrifluorotoluene, due to its unique chemical structure, contains functional groups such as bromine, chlorine and trifluoromethyl, which can participate in many organic reactions and assist chemists in synthesizing drug molecules with specific biological activities. For example, by nucleophilic substitution reactions, bromine or chlorine can be replaced by other biologically active groups, and new drugs can be created to deal with various diseases.
In addition, it also plays an important role in the field of pesticide chemistry. The research and development of pesticides aims to create compounds that have high-efficiency killing or inhibitory effects on harmful organisms and have little impact on the environment and non-target organisms. 4-Bromo-2-chlorotrifluorotoluene can be used as a starting material to synthesize pesticides with unique mechanisms of action through a series of reactions. The presence of trifluoromethyl can often endow compounds with good lipophilicity and stability, which helps to improve the absorption and shelf life of pesticides in vivo, and bromine and chlorine atoms can participate in the formation of structural parts that are toxic to pests or weeds.
In addition, in the field of materials science, this compound has also emerged. In the preparation of some functional materials, 4-bromo-2-chlorotrifluorotoluene can be introduced into polymer materials or organic semiconductor materials as a structural unit. Its special functional groups can adjust the electronic properties, solubility and thermal stability of the material. For example, in organic optoelectronic materials, the charge transport performance of materials can be optimized, the luminous efficiency and device stability can be improved, and the development of organic Light Emitting Diode (OLED) and organic solar cells can be promoted.
In summary, 4-bromo-2-chlorotrifluorotoluene has shown important application value in many fields such as medicine, pesticides and materials science, and is an indispensable key compound in organic synthesis chemistry.
What are the physical properties of 4-Bromo-2-Chlorobenzotrifluoride?
4-Bromo-2-chlorotrifluorotoluene, this is an organic compound. It has many physical properties and is of great significance for chemical research and industrial applications.
Looking at its appearance, 4-bromo-2-chlorotrifluorotoluene is usually a colorless to pale yellow transparent liquid, clear and pure, shimmering under light, like glass. It is stable at room temperature and pressure, but under special conditions, it will also show different chemical activities.
The boiling point is about 190-192 ° C. When heated to this point, the molecule gains energy, breaks free from the attractive forces between molecules, and changes from liquid to gaseous state. This property is crucial in the separation, purification and distillation of substances in chemical production. It helps chemists separate mixtures according to boiling point differences to obtain pure target products.
The melting point is about -30 ° C. When the temperature drops below the melting point, the substance solidifies into a solid state, and the molecular arrangement changes from disorder to order, forming a regular lattice structure. Melting point determination can assist in the identification of the purity of the substance. Impurities in the substance will widen the melting point range and reduce the melting point.
4-Bromo-2-chlorotrifluorotoluene has a density of about 1.71g/cm ³, which is heavier than water. If the two are mixed, it will sink to the bottom. This property needs to be taken into account in liquid-liquid separation operations.
In terms of solubility, it is slightly soluble in water because of its large difference in molecular polarity from water molecules. Water is a strongly polar molecule, while 4-bromo-2-chlorotrifluorotoluene has a weaker polarity. According to the principle of "similar miscibility", the two are difficult to dissolve each other. However, it is soluble in most organic solvents, such as ethanol, ether, acetone, etc. Due to the similar force between organic solvents and its molecules, it can be miscible with each other. This solubility provides a basis for the selection of reaction solvents in organic synthesis, which helps the reaction to proceed efficiently in a suitable medium.
4-bromo-2-chlorotrifluorotoluene is volatile. At room temperature, some molecules obtain enough energy to escape from the liquid surface and emit a special odor. Although the smell is difficult to describe accurately, it is unique. Experienced chemists can preliminarily judge its existence based on the smell. However, caution is required. Because it is toxic and irritating, excessive inhalation or contact with skin and eyes will endanger human health, and protective measures should be taken during operation.
What is the chemistry of 4-Bromo-2-Chlorobenzotrifluoride?
4-Bromo-2-chlorotrifluorotoluene is one of the organic compounds. Its chemical properties are interesting and worth exploring in detail.
In this compound, bromine (Br), chlorine (Cl) and trifluoromethyl (CF 🥰) coexist on a benzene ring. Trifluoromethyl has strong electronegativity, which has a great impact on the electron cloud distribution of the benzene ring. Due to its strong electron-absorbing effect, the electron cloud density of the benzene ring decreases, and the electrophilic substitution reaction activity of the benzene ring decreases.
Both bromine and chlorine are halogen atoms, and the halogen atom belongs to the adjacent and para-localized group on the benzene ring. However, due to the strong electron-absorbing effect of trifluoromethyl, the performance of the halogen atom localization effect is changed
During the electrophilic substitution reaction, the electron cloud density of the benzene ring decreases due to the influence of trifluoromethyl, and the reaction conditions are often more severe than those of benzene. For example, if the nitrification reaction is carried out, more concentrated mixed acid of nitric acid and sulfuric acid is required, and the reaction temperature also needs to be appropriately increased.
Its chemical stability is quite high. Due to the existence of trifluoromethyl, the carbon-fluorine bond energy is very large, which stabilizes the molecular structure. However, under certain conditions, such as high temperature, strong base or strong reducing agent, chemical reactions can also occur.
When encountering nucleophiles, halogen atoms can be replaced. However, due to the electron-absorbing induction effect of trifluoromethyl, the rate and selectivity of nucleophilic substitution reactions will be affected. Generally speaking, bromine atoms are more prone to nucleophilic substitution reactions than chlorine atoms due to their larger atomic radius and relatively small C-Br bond energy.
4-Bromo-2-chlorotrifluorotoluene has unique chemical properties and is significantly affected by the interaction of various groups in the molecule. In the field of organic synthesis, due to its special chemical properties, it can be used as an important intermediate for the preparation of a variety of organic compounds with special properties.
What are 4-Bromo-2-Chlorobenzotrifluoride synthesis methods?
The synthesis method of 4-bromo-2-chlorotrifluorotoluene has been explored by many parties throughout the ages. One common method is to use 2-chloro-4-aminotrifluorotoluene as the starting material. This raw material is first reacted with sodium nitrite and hydrochloric acid through diazotization, and the amino group is converted into diazonium salt at low temperature and fine temperature control. Then, the diazonium salt is mixed with cuprous bromide and hydrobromic acid. After the Sandmeier reaction, the diazonium group is replaced by a bromine atom, resulting in 4-bromo-2-chlorotrifluorotoluene. This process requires careful regulation of reaction temperature, material ratio and reaction time. A slight difference will affect the yield and purity.
Second, 2-chlorotrifluorotoluene is used as the starting material. First, a suitable catalyst, such as an iron-based or aluminum-based catalyst, is used to replace it with bromine at a specific temperature and pressure. However, the selectivity of this reaction is very critical. Due to the different hydrogen activities at different positions on the benzene ring, it is necessary to optimize the reaction conditions with the help of the characteristics of the catalyst, so that the bromine atom precisely replaces the hydrogen at the target position to obtain 4-bromo-2-chlorotrifluorotoluene. In the meantime, the pH of the reaction system and the choice of reaction solvent cannot be ignored, both of which are related to the reaction process and product quality.
In addition, there are also those who use m-chlorotrifluoromethylbenzene as the starting material. First, the nitro group is introduced into a specific position in the benzene ring under suitable nitrifying reagents and conditions. Then the nitro group is reduced to an amino group, and then it is diazotized and reacted with brominating reagents to achieve the substitution of bromine atoms, and the final product is obtained. This route step is slightly complicated, but if the reaction conditions of each step can be properly grasped, 4-bromo-2-chlorotrifluorotoluene with higher yield and purity can also be obtained.
4-Bromo-2-Chlorobenzotrifluoride what are the precautions during use
4-Bromo-2-chlorotrifluorotoluene is a key raw material in organic synthesis. During use, many precautions must not be forgotten.
The first to bear the brunt, safety protection must not be ignored. This compound is toxic and irritating to a certain extent. When operating, be sure to wear complete protective equipment, such as protective gloves, goggles and gas masks, to prevent it from coming into direct contact with the skin, eyes, or being inhaled into the body. Because it can cause damage to the respiratory tract, skin and eyes, if it is inadvertently touched, it needs to be rinsed with a lot of water immediately. If it is serious, it should be quickly treated.
Furthermore, proper storage is also essential. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Because it is a flammable substance, it is very easy to burn and explode in case of open flames and hot topics. At the same time, it should be stored separately from oxidants and alkalis, and must not be mixed to avoid dangerous chemical reactions.
In the process of access and operation, it must be carried out in the fume hood to ensure good ventilation conditions and timely discharge of volatile harmful gases. When taking it, the action must be precise and careful to prevent spillage. Once a spill occurs, it should be cleaned immediately to avoid its spread polluting the environment.
When using this compound for chemical reactions, it is necessary to precisely control the reaction conditions, such as temperature, pressure, reaction time, and the proportion of reactants. Different reaction conditions can have a great impact on the reaction results, or the reaction cannot achieve the desired effect, or even cause side reactions.
In addition, it is also necessary to pay attention to its impact on the environment. After use, the generated waste cannot be discarded at will, and should be properly disposed of in accordance with relevant regulations to prevent pollution to soil, water sources, etc.
In conclusion, when using 4-bromo-2-chlorotrifluorotoluene, regardless of the link, it is necessary to strictly follow the safety operating procedures and relevant regulations, and operate with caution, so as to ensure the safety of personnel and the environment is not endangered, and at the same time, the experiment or production can proceed smoothly.