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What are the main uses of 4-Amino-5-Chloro-Benzotrifluoride?
4-Amino-5-chloro-trifluorotoluene has a wide range of uses. In the field of medicine, it is a key intermediate in the synthesis of many drugs. For example, when creating some new drugs with specific curative effects, 4-amino-5-chloro-trifluorotoluene can be used as a starting material. After a series of delicate chemical reactions, the basic structure of drug molecules can be gradually built, and then the drug is endowed with unique pharmacological activity.
In the field of pesticides, it also plays an important role. It can be used as an important raw material for the synthesis of high-efficiency, low-toxicity and environmentally friendly pesticides. With the help of its synthetic pesticides, it can show excellent control effects on specific crop pests, and has little negative impact on the ecological environment, effectively ensuring the healthy growth of crops and improving the yield and quality of agricultural products.
Furthermore, in the field of materials science, 4-amino-5-chloro-trifluorotoluene can participate in the preparation of functional materials. With its special chemical structure, it endows materials with unique properties such as excellent corrosion resistance and thermal stability, thus expanding the application range of materials, and has potential application prospects in high-end fields such as aerospace and electronic devices. In conclusion, 4-amino-5-chloro-trifluorotoluene plays an indispensable role in many important fields due to its unique chemical properties, which is of great significance for promoting the development of related industries.
What are the physical properties of 4-Amino-5-Chloro-Benzotrifluoride?
4-Amino-5-chloro-trifluorotoluene, this is an organic compound. Its physical properties are crucial and affect many application fields.
First of all, its appearance is often in the state of white to light yellow crystalline powder, with bright color and regular morphology, which is easy to identify visually.
As for the melting point, it is about 83-87 ° C. The melting point is one of the characteristics of the substance. This specific melting point range helps to determine the purity of the compound and is also an important reference for its state change under different thermal environments. In a specific temperature range, the substance gradually melts from solid to liquid. This temperature range is relatively stable, providing a precise temperature basis for related process operations.
Its boiling point is also considerable, usually 260-265 ° C. The boiling point reflects the energy and conditions required for the substance to change from liquid to gaseous. Such a high boiling point indicates that the compound is relatively stable and will only gasify at higher temperatures. It can maintain a liquid or solid state under normal heating conditions, which is conducive to storage and specific high temperature treatment processes.
In terms of solubility, 4-amino-5-chloro-trifluorotoluene is slightly soluble in water. Water is a common solvent, and its slightly soluble properties indicate that it interacts weakly with water molecules, and its molecular structure makes it difficult to disperse in water. However, it is soluble in organic solvents such as ethanol and acetone. The molecular structure of organic solvents such as ethanol and acetone has certain similarities to this compound, and follows the principle of similar miscibility, so it can be well miscible. This solubility characteristic is extremely important in organic synthesis, separation and purification, etc., and appropriate solvents can be selected for related operations according to different solubility.
In addition, 4-amino-5-chloro-trifluorotoluene has a certain odor. Although the odor description is difficult to accurately quantify, its special odor is also one of the physical properties of the substance. It can be sensed by smell during contact and use, and can be used as a preliminary basis for judgment to some extent.
The above physical properties, such as appearance, melting point, boiling point, solubility and odor, together outline the physical properties of 4-amino-5-chloro-trifluorotoluene, which are of great significance for its application and research in chemical, pharmaceutical and other fields.
What is the chemistry of 4-Amino-5-Chloro-Benzotrifluoride?
4-Amino-5-chloro-trifluorotoluene has unique chemical properties. It has the typical characteristics of aromatic compounds, and the benzene ring endows it with certain stability. The amino group (-NH ²) is an important functional group, which is basic and can react with acids to form corresponding salts. This is because the nitrogen atom in the amino group has a lone pair of electrons and can accept protons.
Furthermore, the chlorine atom (-Cl) attached to the benzene ring has a large electronegativity, which will affect the electron cloud distribution of the benzene ring, reduce the electron cloud density of the benzene ring, and then affect the electrophilic substitution reaction activity on the benzene ring. Usually, chlorine atoms are ortho-and para-localizers, which can guide electrophilic reagents to attack the ortho-and para-localizations of the benzene ring under appropriate conditions.
The existence of trifluoromethyl (-CF <) greatly changes the electronic properties and spatial structure of the molecule. Due to its strong electron absorption, it not only further reduces the electron cloud density of the benzene ring, but also significantly affects the polarity and fat solubility of the molecule. This makes 4-amino-5-chloro-trifluorotoluene exhibit good solubility in organic solvents.
In chemical reactions, amino groups can participate in a variety of reactions, such as reacting with acyl chloride to form amides, reacting with aldose and ketone to form Schiff bases, etc. Under the action of suitable nucleophiles, chlorine atoms can undergo nucleophilic substitution reactions and be replaced by other groups. The special properties of trifluoromethyl have far-reaching effects on the reactivity, stability and biological activity of the whole molecule, and are of great value in the fields of organic synthesis and medicinal chemistry.
What is 4-Amino-5-Chloro-Benzotrifluoride production method?
The preparation of 4-amino-5-chloro-trifluorotoluene is particularly complicated and requires many steps and delicate operations.
Start with an appropriate aromatic hydrocarbon as the base material. This aromatic hydrocarbon needs to have a specific substituent distribution in order to be accurately converted in subsequent reactions. First, a halogenation reaction is carried out, usually by chlorination. In a specific reaction vessel, an aromatic hydrocarbon, an appropriate amount of chlorination reagent and a suitable catalyst are added. The chlorination reagent may be chlorine gas or other chlorides, depending on the reaction conditions and cost considerations. The catalyst is also crucial, or a metal halide or the like, can effectively promote the chlorination reaction. Control the reaction temperature, pressure and time, so that chlorine atoms are introduced into specific positions on aromatics to form chlorine-containing intermediates.
Then, a nitration reaction is carried out. In the above chlorine-containing intermediates, a nitrifying reagent is added, such as a mixed acid system of nitric acid and sulfuric acid. This mixed acid can introduce nitro groups into the benzene ring of the intermediate. This step requires strict control of the reaction conditions. Due to the intense nitrification reaction, excessive temperature can easily lead to side reactions and impure products. After nitrification, a product containing chlorine and nitro groups is obtained.
Next, a reduction reaction is carried out, aiming to convert nitro groups into amino groups. Commonly used reducing agents include iron powder, zinc powder, etc. Under specific solvent and reaction environment, the nitro group is gradually reduced to amino group to form 4-amino-5-chloro-benzene derivatives.
Finally, the trifluoromethylation reaction is carried out. This step requires the use of special trifluoromethylation reagents, such as trifluoromethyl halides or other active reagents containing trifluoromethyl. Under suitable reaction conditions, trifluoromethyl is added to the benzene derivative to obtain 4-amino-5-chloro-trifluorotoluene. The whole preparation process, the reaction conditions, the amount of reagents, and the purification and separation of intermediate products in each step need to be carefully controlled to obtain high-purity target products.
What is the price range of 4-Amino-5-Chloro-Benzotrifluoride in the market?
4-Amino-5-chloro-trifluorotoluene is in the market, and its price is variable due to many reasons.
In the city of the past, its price often varies according to the quality and quantity. If the quality is pure and the quantity is abundant, the price may be slightly cheaper; if the quality is inferior and the quantity is rare, the price will be high. And the source material of this compound is difficult to harvest and process, which also affects its price. The source material is easy to obtain, and the construction method is simple, and the price is more close to the people; on the contrary, the source material is rare and the construction method is complicated, so the price is high and difficult to climb.
In addition, the supply and demand of the city is also the key. The demand is prosperous but the supply is limited, and the price will rise; if the supply exceeds the demand, the price will tend to fall. And the situation of the world and the rules of the government also have an impact. If there is a time of chaos, or the government changes, the transportation of sources and materials is blocked, and the production is difficult to continue, the price will be volatile.
Although it is difficult to determine the fixed price of its price, looking at the past market conditions, roughly speaking, its price per kilogram or hovering between hundreds of gold and thousands of gold. However, this is only speculation, and the actual price must be carefully investigated according to the current market conditions and the requirements of the supplier. The purchaser should widely observe the prices of various companies, carefully examine the high and low quality, and weigh the comparison before he can get the right price and buy this product.